What do ‘Bohemian Rhapsody,’ ‘Macbeth,’ and a list of Facebook Friends All Have in Common?

New research finds that works of literature, musical pieces, and social networks have a similar underlying structure that allows them to share large amounts of information efficiently.

Examples of statistical network analysis of characters in two of Shakespeare’s tragedies. Two characters are connected by a line, or edge, if they appear in the same scene. The size of the circles that represent these characters, called nodes, indicate how many other characters one is connected to. The network’s density relates to how complete the graph is, with 100% density meaning that it has all of the characters are connected. (Image: Martin Grandjean)

 

By Erica K. Brockmeier

To an English scholar or avid reader, the Shakespeare Canon represents some of the greatest literary works of the English language. To a network scientist, Shakespeare’s 37 plays and the 884,421 words they contain also represent a massively complex communication network. Network scientists, who employ math, physics, and computer science to study vast and interconnected systems, are tasked with using statistically rigorous approaches to understand how complex networks, like all of Shakespeare, convey information to the human brain.

New research published in Nature Physics uses tools from network science to explain how complex communication networks can efficiently convey large amounts of information to the human brain. Conducted by postdoc Christopher Lynn, graduate students Ari Kahn and Lia Papadopoulos, and professor Danielle S. Bassett, the study found that different types of networks, including those found in works of literature, musical pieces, and social connections, have a similar underlying structure that allows them to share information rapidly and efficiently.

Technically speaking, a network is simply a statistical and graphical representation of connections, known as edges, between different endpoints, called nodes. In pieces of literature, for example, a node can be a word, and an edge can connect words when they appear next to each other (“my” — “kingdom” — “for” — “a” — “horse”) or when they convey similar ideas or concepts (“yellow” — “orange” — “red”).

The advantage of using network science to study things like languages, says Lynn, is that once relationships are defined on a small scale, researchers can use those connections to make inferences about a network’s structure on a much larger scale. “Once you define the nodes and edges, you can zoom out and start to ask about what the structure of this whole object looks like and why it has that specific structure,” says Lynn.

Building on the group’s recent study that models how the brain processes complex information, the researchers developed a new analytical framework for determining how much information a network conveys and how efficient it is in conveying that information. “In order to calculate the efficiency of the communication, you need a model of how humans receive the information,” he says.

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Penn Postdoctoral Researcher David Lydon-Staley Appointed Assistant Professor in Annenberg School for Communication

by Sophie Burkholder

A Penn Bioengineer will soon join the Annenberg School for Communication as an Assistant Professor of Communication. David Lydon-Staley, Ph.D., recently completed two years as a Postdoctoral Researcher in Penn’s Complex Systems Lab, led by Danielle Bassett, Ph.D., the J. Peter Skirkanich Professor of Bioengineering and Electrical and Systems Engineering.

David Lydon-Staley, Ph.D.

Lydon-Staley started out studying English and Psychology in his undergraduate education, going on to pursue a Ph.D. from Penn State University in Human Development and Family Studies. What brought him to Bassett’s lab was his interest in using cognitive neuroscience to understand the brain patterns and behaviors behind substance abuse and addiction. There, Lydon-Staley examined networks of nicotine withdrawal behaviors, how those behaviors impact each other, and what information they might hold about how to help smokers in their quit attempts. “David’s breadth of interest is only rivalled by his expansive expertise and bottomless enthusiasm,” says Bassett. “I feel incredibly lucky to have had the chance to work with him.”

In his new role at Annenberg, Lydon-Staley will launch the Addiction, Health, and Adolescence Lab, or “AHA!” for short. “My recent work examines engagement with new media during the course of daily life, and how the information sought and encountered relates to both curiosity and substance use,” he says. Lydon-Staley’s new lab will use methods like experience-sampling and functional Magnetic Resonance Imaging to understand brain and behavior, while drawing on theories and tools from  communication, psychology, cognitive neuroscience, network science, and more.

Even though Lydon-Staley will be working out of a new school at Penn, he still has plans to continue collaborating with the Bassett Lab. One ongoing project he has with the lab involves studying how curiosity works in everyday life, and another looks at moment-to-moment patterns of cigarette withdrawal in daily smokers. “Working in the Bassett Lab gave me the confidence and ability to stretch my wings, chase ideas across traditional disciplinary lines, learn new skills, and collaborate with creative and capable scientists every day,” says Lydon-Staley. Those are opportunities he hopes to keep chasing and fostering in his new position.

Beyond continuing his prior research from a communication-based angle, Lydon-Staley is also excited to develop new classes in the Annenberg School. “Annenberg is a very special place. It is an active school, with frequent seminars and many vibrant research centers,” he says. Informed and inspired by the breadth of research from Annenberg scholars, Lydon-Staley hopes that he can create classes that focus on the psychology of time and timing in everyday life—topics that he spends a lot of time thinking about himself.

Above all, Lydon-Staley is excited by the opportunity to stay at Penn and continue the kind of versatile and multi-faceted studies that have been the bedrock of his research so far. He hopes to continue expanding his previous work with not only the Engineering School, but the School of Medicine and the Graduate School of Education as well. “The opportunities for interdisciplinary collaboration at Penn are unrivaled, and I am constantly in awe of the quality of students here.”

Penn Bioengineering Former Postdoc Whelton Miller Appointed Assistant Professor Loyola University

 

Whelton Miller, Ph.D.

The Department of Bioengineering is proud to congratulate Whelton Miller, Ph.D., a former BE Postdoctoral Fellow, on his appointment as an Assistant Professor in the Department of Medicine in the Health Sciences Division at Loyola University. Miller’s appointment began in January 2020.

Miller received his B.S. in Biochemistry in 2001 from the University of Delaware where he worked under the supervision of Dr. Douglass F. Taber. After graduation, he worked in industry as a synthetic organic chemist for a pharmaceutical company. After three years of industry experience, he returned to academia to complete a Ph.D. in Theoretical/Computational Chemistry from the University of the Sciences in Philadelphia in 2012.

After graduate school, he was given a unique opportunity through Penn’s Postdoctoral Opportunities in Research and Teaching (PennPORT) program, an NIH-sponsored, Institutional Research and Academic Career Development Award (IRACDA) postdoctoral fellowship. In addition to Miller’s responsibilities through the PennPORT program, he served on the Biomedical Postdoctoral Council (BPC), as well as chair of the Engineering PostDoc Association (EpoD). He has worked closely with the Physician Scientist Training Program (PSTP) as a mentor to a high school student, as well as a program guest speaker. This allowed Miller to be a Postdoctoral Research Fellow in the Department of Bioengineering at Penn in the Radhakrishnan Lab – led by BE Department Chair Ravi Radhakrishnan – which focuses on the interface between chemical physics and molecular biology.

Miller has also gained experience in various affiliated appointments, serving as an Assistant Professor in the Department of Chemistry and Physics at Lincoln University (2015-2019), and is currently an Adjunct Assistant Professor in the Department of Chemical and Biomolecular Engineering (CBE) at Penn and an Adjunct Professor in Biomedical Engineering at the University of Ghana in Accra.

Miller joined Loyola University in Chicago, IL in the summer of 2019. Now in his new faculty position, Miller continues to work on collaborative research projects and include colleagues at Instituto Tecnológico de Santo Domingo, the University of Pennsylvania, Lincoln University, University of Ghana, and the University of the Sciences. His current research involves using computational chemistry techniques for theoretical design and study of organometallic and inorganic compounds, protein ligand interactions, and structural electronic effects. His goal is to employ several computational techniques to understand, as well as predict, molecular interactions, such as protein-ligand interactions and protein-protein interactions. Miller says he is always looking forward to more opportunities for minority student development and enrichment in the STEM-related disciplines. Congratulations, Dr. Miller!

 

Penn Bioengineering Postdoc Rachel Riley Named Assistant Professor at Rowan University

Rachel Riley, Ph.D.

The Department of Bioengineering is proud to congratulate Postdoctoral Fellow Rachel Riley on her appointment as an Assistant Professor in Biomedical Engineering at Rowan University starting September 2020.

Originally from Matawan, NJ, Riley has been an NIH Postdoctoral Fellow in the Mitchell Lab since 2018. Her move to a faculty position at Rowan marks a return, as she received her B.S. in Civil and Environmental Engineering there in 2012. Riley went on to receive her Ph.D. in Biomedical Engineering in 2018 at the University of Delaware with Emily Day, Ph.D. before joining the lab of Michael J. Mitchell, Ph.D., Skirkanich Assistant Professor of Innovation, later that year. The Mitchell Lab’s research lies at the interface of biomaterials science, drug delivery, and cellular and molecular bioengineering to fundamentally understand and therapeutically target biological barriers.

“Rachel has had a prolific academic career at the University of Delaware and at Penn, launching several exciting research projects and mentoring the next generation of STEM researchers,” Mitchell says. “I’m very hopeful that her new position as an Assistant Professor of Biomedical Engineering at Rowan University will permit her to engineer new drug delivery technologies for women’s health applications.”

Research in the Riley Lab at Rowan will explore how nanoparticle drug delivery technologies can be engineered specifically for applications in women’s health. They will use nanoparticles as tools to study and treat gynecological cancers, fetal diseases, and pregnancy complications. Riley’s ultimate goal is to gain a fundamental understanding of how nanoparticle structure influences delivery to gynecological tissues to enable them to take an engineering approach to tackle new applications in women’s health.

Riley says that she is committed to supporting women and minorities in STEM disciplines and she looks forward to continuing collaborations with Penn and starting new collaborations with researchers at Cooper Medical School at Rowan University (CMSRU). Congratulations, Dr. Riley!