Scaling Student Innovation: Enginuity Powers Community-Driven Engineering

At the University of Pennsylvania, student-led projects through Penn ADAPT (Assistive Devices and Prosthetic Technologies) have demonstrated how engineering can move beyond the classroom to address real-world challenges, from assistive devices to clinical tools. But as those efforts grew, so did a fundamental constraint: connecting students with the communities and organizations who needed their skills.

Brianna Leung, a graduating M.S.E. student in Bioengineering and former president of Penn ADAPT, saw that gap firsthand. While student teams were eager to build and community needs were abundant, sourcing projects often required months of outreach, coordination and persistence. Through her work with community partners, including ongoing engagement with HMS School for Children with Cerebral Palsy, a Philadelphia-based school serving students with complex disabilities, Leung saw both the demand for assistive solutions and the barriers to accessing them.

In response, she helped develop Enginuity, a platform that allows community partners to post engineering challenges directly, connecting them with student teams more efficiently to address real-world needs.

Now, as Leung prepares to graduate, leadership of Enginuity will transition to Andrew Yao, a second-year in Bioengineering and vice president of Penn ADAPT. Yao will continue expanding the platform’s reach and impact. Together, their perspectives highlight both the platform’s origins and its next phase.


Q: During your involvement with Penn ADAPT what gaps did you start to notice in how projects were sourced or developed, and how did that lead to Enginuity?

The goal with ADAPT was always to use engineering as a force for change in Philadelphia. I’ve always preferred working on projects with a real-world end goal. When we have a student body that is skilled, well-resourced and eager to build, it doesn’t make sense to focus only on hypothetical problems.

We started reaching out to community partners, beginning with cold emails and early pilot projects. Over time, the number of potential projects began to outpace our capacity. That’s when we started thinking about how to make this kind of work more accessible. Enginuity grew out of that idea, as a way to build a more direct and scalable connection between student engineers and community needs.


Q: Enginuity allows organizations to post their own engineering challenges. What changes when the community defines the problems?

A huge part of engineering is listening and understanding a problem. The community knows best what it needs.

When organizations define their own challenges, students gain a much richer experience. You’re not just solving a predefined problem—you’re translating real-world constraints, user needs and qualitative feedback into something tangible. That process builds both technical skills and empathy.


Q: What are the biggest barriers today for students who want to engage in real-world engineering problem-solving, and how does Enginuity address them?

At Penn, everyone is incredibly busy. From my own experience, it took a full summer of emails, meetings and coordination to establish our first collaboration. Building those relationships can take years, and most students don’t have the time to navigate that process.

Enginuity simplifies that by creating a centralized space where community members can submit project ideas. Instead of starting from scratch, students can focus on the work itself, connecting more quickly and collaborating more effectively.


Q: Many student projects are tied to a semester or a single team. Why was it important to build a platform instead of focusing on individual projects?

We’re hoping to generate more projects overall. Through ADAPT, we saw that there was a lot of need, but not enough people available to handle the outreach and logistics.

By building a platform, we can remove some of those barriers and allow more students to get involved. The goal is to make it easier for engineers to focus on solving problems rather than finding them.


Q: How do you see Enginuity changing the relationship between Penn and the Philadelphia community?

Penn is an incredibly well-resourced institution, and ADAPT has benefited from support across labs, departments and staff. There’s a real opportunity to use those resources to make a meaningful impact in Philadelphia.

At the same time, Philadelphia has the highest per-capita disability rate of any major U.S. city. As engineers, we have a responsibility to contribute where we can. I hope Enginuity helps build a more consistent and dependable connection, so community members feel they can turn to us for support.


Q: If Enginuity succeeds at the scale you envision, what could it change about how engineering solutions are developed and shared?

Student engineers occupy a unique space, especially in areas like assistive technology. Many devices for specialized needs are either unavailable or extremely expensive.

Every week, through my work with HMS School, I see devices that cost hundreds of dollars but could be built for a fraction of that. That gap highlights both the challenge and the opportunity. I hope Enginuity can mobilize a broader network of student engineers to help fill those gaps and expand access to these kinds of solutions.


Q: How has building Enginuity shaped the way you think about engineering and your role as a bioengineering student?

Building Enginuity has been an exploration of how projects generate learning. In traditional coursework, there are clearly defined skills and relatively low stakes. However, with Enginuity, real-world problems can be solved in many different ways, and students may develop completely different technical skills working on the same challenge. At the same time, the stakes are higher. Delivering a solution in a real-world setting and maintaining relationships with our partners requires follow-through, and that can be difficult to guarantee. These questions, how to structure projects, how to support students and how to ensure meaningful outcomes, have shaped how I think about engineering as both a technical and systems-level discipline.

Developing the platform also required thinking about accessibility from the start. We worked to ensure the site is usable for individuals with disabilities, incorporating features such as screen-reader compatibility, adjustable text and clear navigation. In that sense, Enginuity is not only a tool for engineering projects, but an engineering project itself.


As Enginuity continues to grow, its long-term impact will depend on sustained student leadership. With Leung graduating, that responsibility will shift to Andrew Yao (BE’28), vice president of Penn ADAPT, who has been involved in the organization’s projects and outreach.

Yao sees Enginuity not only as a way to expand access to engineering projects, but also as an opportunity to strengthen connections between students and the communities they aim to serve.


Q: What excites you about taking over leadership of Enginuity?

I’m excited to continue working with community partners and expand ADAPT’s outreach. We recently showcased Enginuity at the Philly Maker Faire and received a lot of positive feedback, which showed there’s a real need for this kind of platform.

I’m looking forward to building on what Brianna started, connecting organizations and individuals with student problem-solvers to create a greater impact in the Philadelphia community.


Q: How does Enginuity shape the way students approach engineering problems?

It helps keep the focus on the end user. As engineers, it’s easy to get caught up in the technical side and lose sight of whether a solution is actually practical.

On one of my projects, we initially designed a robotic system to assist surgeons, but after speaking with clinicians, we learned it wouldn’t be feasible in practice. That kind of feedback is critical, and Enginuity encourages more of those conversations early in the process.


Q: Where can community partners go to submit a project, and what information do they need?

Community partners can submit projects through the Enginuity page on the Penn ADAPT website or contact us directly by email (pennadapt@gmail.com). We ask for a description of the problem, and while additional materials like images or videos are helpful, they’re not required.

We’ve designed the platform to be accessible and easy to use, so partners don’t need a technical background to participate.


As Enginuity expands, it reflects a broader shift in how engineering education and practice intersect, not only building solutions, but building the pathways that make those solutions possible.

Rose Undergraduate Research Award Recipient Yerahm Hong Q&A

The Rose Undergraduate Research Award, administered by Penn’s Center for Undergraduate Research and Fellowships (CURF), recognizes outstanding and highly original research projects completed by graduating seniors under the guidance of Penn faculty. In this Q&A, Yerahm Hong (BE’26), a 2026 award recipient, shares her research journey and reflects on the work behind the award.

Can you describe your research project and its significance in terms a general audience can understand?

My project aims to assess the effectiveness of an antisense oligonucleotide (ASO) gene therapy for KCNC1-related developmental and epileptic encephalopathy (DEE). Pediatric patients with these rare genetic disorders suffer from spontaneous seizures, developmental delays, and intellectual disabilities, all deeply affecting their quality of life and the lives of their families. In these disorders, the body is making a protein that doesn’t work correctly, which causes misregulation of the brain’s electrical signals. The ASO therapy is designed to go into the cells and “intercept” the genetic instructions, preventing the faulty protein from being made in the first place. By testing this therapy in a mouse model, we’re moving closer to a cure in a world where current options like medications, special diets, and surgery remain limited in their effectiveness.

What problem does your research aim to address, and why is it important?

We’re addressing the lack of targeted treatments for rare genetic epilepsies. We’ve shown promising preliminary results for this ASO, which opens doors to potentially effective therapies for clinical trials.

What drew you to this research topic and working with Ethan Goldberg, Associate Professor of Neurology?

I’ve worked with Dr. Goldberg since the summer of my freshman year. Taking “Introduction to Brain and Behavior” as an elective sparked a curiosity for neuroscience that I decided to explore in the lab. Over the last few years, I’ve worked on various projects investigating the mechanisms of pediatric epilepsy through mouse models.

Why did you transition to this specific project?

I started this project in the summer of my junior year because I wanted to explore translational research. Since I had already contributed to the characterization of the mouse model for KCNC1-related DEE, it made sense to transition to exploring this specific therapeutic approach.

What was your specific role in the project?

My role involved injecting the ASO for each cohort of mice and conducting survival and behavioral studies to see how well the therapy worked. Currently, I’m collaborating with other research scientists and mentors in the lab to move the project forward. 

Was there a particularly challenging or rewarding moment in your research experience?

Recently, I achieved an interesting result quantifying the level of Kv3.1 protein knockdown by the ASO. The Western Blot experiment, a lab technique that separates proteins by molecular weight, was not guaranteed to work because it required many extensive steps. Completing it without mistakes with the help of my mentor was a very rewarding moment.

What has this experience taught you about the nature of research?

It taught me that research requires an enjoyment of the troubleshooting process. The attention to detail required to execute experiments effectively is a skill I hope to continue building throughout my career.

How did working with Ethan Goldberg, Associate Professor of Neurology, shape your experience?

Dr. Goldberg cultivated a lab environment conducive to learning, mentorship, and independence. He has been a kind mentor and role model who invested in me both professionally and personally. I’m very fortunate to have had this opportunity throughout my undergraduate years. I also deeply appreciate the daily mentorship of Sophie Liebergall, MD-PhD Candidate at University of Pennsylvania School of Medicine, and Dr. Kelly Markwalter, Postdoctoral Research/Clinical Fellow at the Children’s Hospital of Philadelphia. 

What does receiving the Rose Award mean to you?

I am profoundly humbled and encouraged by this recognition. Receiving this award is a testament to the wonderful work of my mentors in helping shape who I am as an aspiring physician-scientist. Working with people who are genuinely passionate about what they do is contagious.

What advice would you give to students who are just getting started with research?

Don’t give up! Enjoy the process and take advantage of the resources available at Penn. The time scale at which biomedical research moves is far beyond your time here, so it’s important to put things into perspective as you explore.

How has this experience influenced your future goals?

Being in a great research environment has given me a strong desire to pursue the physician- scientist path. Through an MD-PhD, I hope to gain the skills I need to make great research ideas into a reality. I’ve been bitten by the science bug, and I hope that I can channel this energy to advancing the latest neurotechnologies through research.

Summer Research Spotlight: Penn Bioengineering Fellows at Work

Each year, the the Department of Bioengineering seeks exceptional candidates to conduct summer research in bioengineering with the support of scholarships. This summer students participated in the Abraham Noordergraaf Student Summer Bioengineering Research Fellowship, the Blair Undergraduate Research Fellowship in the Department of Bioengineering, and the IGEM Fellowship. These scholarships provide a living stipend for students to conduct research on campus in a Penn research lab under the mentorship of a faculty member.

Meet Our Summer Fellows

Abraham Noordergraaf Research Fellow

Name: Patricia Chen

Current Year and Major Program: Second year master’s student in Bioengineering

Faculty Mentor: Dr. Kevin Johnson

Project Title: PCP-Bot: Leveraging Large Language Models for Multilingual AI-Assisted Pre-Visit Planning in Primary Care

Abstract: With the rise of electronic health records (EHRs), physicians now devote a substantial portion of patient encounters to clinical documentation, reducing the time available for direct patient interaction. Pre-visit planning is an important strategy for reviewing essential information in advance to improve efficiency, outcomes, and satisfaction. Increasingly, AI-powered chatbots are being deployed in healthcare settings. These systems offer a promising way to streamline this process. However, despite its growing adoption, chatbot performance disparities persist between English and non-English users. Recent cross-lingual LLM evaluations highlight up to an 18% drop in response correctness and a 29% decline in consistency for non-English queries, raising equity and safety concerns. To address these disparities, we developed PCP-Bot, an AI-powered chatbot for pre-visit planning that gathers patient history and concerns before the clinical encounter, then creates a concise, 300-word summary for clinical use. We evaluated its performance across English and non-English interactions using standardized simulated patient scenarios, assessing correctness, consistency, and completeness. Results will guide improvements in multilingual functionality of PCP-Bot to enhance equity, safety, and effectiveness in diverse patient populations.

Blair Undergraduate Research Fellowship in the Department of Bioengineering

Name: Alex Schnurman

Current Year and Major Program: Class of 2028, Biochemistry

Faculty Mentor: Dr. Noor Momin

Project Title: Using APEX2-based proximity labeling to identify lysosome-associated proteins

Abstract: Hypertrophic cardiomyopathy is an inherited heart disease that affects 1 in 500 people a year. RNA interference therapies, such as small interfering RNA (siRNA), could address causal gene expression, but effective delivery to cardiomyocytes remains a substantial barrier for siRNA delivery. We aim to nominate cell-surface entry points for delivering siRNA therapies to the lysosomal compartment of cardiomyocytes to maximize siRNA escape from the endolysosomal compartment. As a first step, we are developing a proximity labeling-based platform to identify lysosome-associated proteins as the first step towards nominating ideal targets for siRNA therapy. We expressed a proximity labeling enzyme tethered to the lysosomal protein to biotinylate lysosome-specific proteins. Flow cytometry demonstrated successful expression of the enzyme construct and microscopy verified expression of the construct in puncta, suggesting localization to endolysosomal compartments. We then optimized procedures to initiate proximity labeling to biotinylate nearby proteins and microscopy showed biotinylation of proteins in puncta. These results are the first step towards a lysosome-specific module that can pair with complementary techniques to identify cardiomyocyte-specific target proteins for siRNA delivery.

IGEM Fellow

Name: Yifan Zhai

Current Year and Major Program: Class of 2028, Bioengineering

Faculty Mentor: Dr. Lukasz Bugaj

Project Title: Screening Synthetic Binders for EML4-ALK

Abstract: Our overall goal is to develop synthetic protein circuits that sense a cell’s oncogenic state and eliminate the cell in response. There is currently an urgent need for therapies that can: (1) sensitively distinguish cancer cells from healthy cells, (2) directly initiate cancer cell death, and (3) efficiently clear the tumor. Our approach works by first recognizing specific oncogenic proteins and subsequently executing a desired pathway of programmed cell death in response. To realize this vision, our goal for the summer was to engineer and identify protein binders that specifically localized to these target oncogenes, a critical missing link that would allow our engineered therapies to respond to the appropriate molecules. We designed and assembled multiple test constructs, introduced them into cells expressing fluorescently labeled targets, and then assessed their function using live-cell imaging and biochemical assays to evaluate binding efficiency. Through this project, I developed skills in molecular cloning, mammalian cell culture, live-cell imaging, and image analysis.

Who, What, Why: Lasya Sreepada on Decoding Alzheimer’s Disease

by Nathi Magubane

Lasya Sreepada, Ph.D. student in Bioengineering

Lasya Sreepada has always been fascinated by the brain and the underlying biology that shapes how people develop and age. “My curiosity traces back to observing differences between myself and my sister,” says Sreepada, a Ph.D. candidate in Bioengineering whose research unites efforts across Penn Medicine and Penn Engineering. “We grew up in the same environment but had remarkably different personalities, which led me to question what drove these differences and which brought me to the brain.”

Her academic journey began by applying medical imaging to understand how brain injuries sustained by professional athletes or military veterans impact their brain structure and chemistry over time. She became curious about how neurotrauma impacts aging and degeneration in the long term. Now, she leverages large, multimodal datasets to investigate neurodegenerative disease, with a particular focus on Alzheimer’s.

Read the full story in Penn Today.

Lasya Sreepada is a Bioengineering Ph.D. student at the Bioinformatics in Neurodegenerative Disease (BiND) Lab at Penn, advised by Corey McMillan and Dave Wolk, both Associate Professors in Neurology and members of the Bioengineering Graduate Group.

Student Spotlight: Cosette Tomita

Cosette TomitaCosette Tomita, a master’s student in Bioengineering, spoke with Penn Engineering Graduate Admissions about her research in cellular therapy and her path to Penn Engineering.

“What were you doing before you came to Penn Engineering? 

After college I wanted to get some industry experience before going to graduate school, so I spent a year working for a pharmaceutical company in New Jersey. I learned a lot—but mostly I learned that I wanted to go back into academia. So I was looking for a more research-oriented position to boost my graduate school applications, and I found a position at Penn’s cyclotron facility. Shortly after that, I applied to the master’s program. I’m still working at the cyclotron, so I’m doing the program part time. 

How has your experience in the program been so far? 

I love the research I’m doing here. I love the collaboration we have and the fact that I’m able to work with whoever I want to. And I can only say good things about my PI, Robert Mach. He’s a very busy man, but he makes time for his people. And he recognizes when somebody has a lot on their plate and he will go to bat for that person.

What’s your research all about? 

The focus of my PI’s lab is on neurodegenerative diseases and opiate use, so we’re looking to make imaging agents and antagonists that can help with the opioid crisis. 

For my project, I wanted to look at treating neurodegenerative disease from the perspective of cellular therapy. My PI doesn’t have that expertise, so when I came to him with this idea, he said I should talk to Mark Sellmyer in the bioengineering department. He does a lot of cellular therapies, cell engineering, protein engineering and things of that nature. So his lab is more biological. 

I don’t have a grant for my research, so my advisors are supporting it out of their own pockets. They could have said, no, you need to work on this project that’s already going on in the lab. But they gave me the intellectual freedom to do what I wanted to do.”

Read the full Q&A at the Penn Engineering Graduate Admissions website.

Mark Sellmeyer is Assistant Professor of Radiology in the Perelman School of Medicine and member of the Penn Bioengineering Graduate Group.

Could Psychedelics Simultaneously Treat Chronic Pain and Depression?

Ahmad Hammo

Ongoing clinical trials have demonstrated that psychedelics like psilocybin and LSD can have rapid and long-lived antidepressant and anti-anxiety effects. A related clinical problem is chronic pain, which is notoriously difficult to treat and often associated with depression and anxiety.

This summer, Ahmad Hammo, a rising third-year student in bioengineering in the School of Engineering and Applied Science, is conducting a pilot study to explore psilocybin’s potential as a therapy for chronic pain and the depression that often accompanies it.

“There’s a strong correlation between chronic pain and depression, so I’m looking at how a psychedelic might be used for treating both of these things simultaneously,” says Hammo, who is originally from Amman, Jordan.

Hammo is working under the guidance of neuroanesthesiologist and neuroscientist Joseph Cichon, an assistant professor in the Perelman School of Medicine. The effort is supported by the Penn Undergraduate Research Mentoring (PURM) program, administered by the Center for Undergraduate Research and Fellowships, which awards undergraduate students $5,000 to spend 10 weeks conducting research alongside Penn faculty.

Hammo’s project focuses on neuropathic pain, pain associated with nerve damage. Like other forms of chronic pain, most experts believe that chronic neuropathic pain is stored in the brain.

“Neuropathic pain can lead to a centralized pain syndrome where the pain is still being processed in the brain,” Cichon says. “It’s as if there’s a loop that keeps playing over and over again, and this chronic form is completely divorced from that initial injury.”

Read the full story in Penn Today.

Student Summer Research Spotlight: Dahin Song

Dahin Song
Dahin Song (BE 2024)

Dahin Song, a third year undergraduate student in Bioengineering, penned a guest blog post for Penn Career Services as part of their ongoing series of posts by recipients of the 2022 Career Services Summer Funding Grant. In this post, Song talks about her opportunity to conduct research in the SMART Lab of Daeyeon Lee, Professor and Evan C. Thompson Term Chair for Excellence in Teaching in the Department of Chemical and Biomolecular Engineering and member of the Penn Bioengineering Graduate Group. During her summer research, Song worked on increasing the stability of the monolayer in microbubbles, gas particles which have been put to therapeutic use. She writes:

“My project was on increasing the stability of the monolayer using cholesterol; theoretically, this would decrease the permeability while maintaining the fluidity of the monolayer. Being given my own project at the get-go was initially intimidating; initial learning curve was overwhelming – along with new wet lab techniques and protocols, I learned a whole new topic well enough to ask meaningful questions. But in retrospect, throwing myself headlong into a project was the best method to immerse me in the research environment, especially as a first-time researcher. I learned how to read papers efficiently, troubleshoot research problems, navigate in a laboratory environment, and be comfortable with working independently but more importantly, with others.”

Read “The Itsy Bitsy Bubble” in the Career Services blog.

Student Spotlight: Jerry Gao

Ego of the Week: Jerry Gao
Jerry Gao (photo credit: Nathaniel Babitts)

Fourth year undergraduate Jerry Gao (BE ’23) is the latest student featured in 34th Street Magazine’s “Ego of the Week” series. Jerry, who hails from Coppell, TX, majors in Bioengineering with a minor in Asian American Studies. In addition to his academic studies, he is passionate about education and literacy, working with The Signal, the Asian Pacific American Leadership Initiative, and the Penn Reading Initiative. In this Q&A, he discusses the sense of community that brought him to Penn, the love of cooking (and gifting food to his friends) that powers his @gaos_chows Instagram account, and his experience as a student and now TA in Penn Bioengineering’s “BE MAD” lab class:

“Now that you’re on your way to graduating, what have been your favorite classes or experiences in Bioengineering or Asian American Studies?

‘In terms of bioengineering, there’s definitely a clear favorite that I have. It’s actually the class I’m a TA for right now. It’s “Bioengineering Modeling, Analysis, and Design,” and it’s basically the lab that all junior bioengineers take. There’s one particular lab we do in the class that always catches everyone’s attention; it’s called the cockroach lab. I think it’s one of the biggest reasons why people want to study bioengineering at Penn in particular.

It’s a segue into prosthetics and different medical devices that can help restore people’s limb functions. We order hundreds of cockroaches and then we put them in a little bit of an ice bath to anesthetize. We amputate their legs, which will essentially serve as our prosthetics, and then implant metal electrodes into two different spots of the leg. Then, we go into our computer program and type different lines of code that can help replicate different signal waves to move the legs. If you submit a wave with a particular frequency and particular amplitude, it’ll cause a leg to move in one direction, and if you do a different combination of the amplitude and frequency, it’ll cause it to move in the other direction. The next task is to trace the end of the leg and try to choreograph the leg to spell the letters B and E for bioengineering. It’s so fun to be able to see what combination of leg movements in the servo motor can form the backbone of the B for example, what can form the three lines of the E. I would say that’s probably my favorite moment in the bioengineering department.'”

Read “Ego of the Week: Jerry Gao” in 34th Street.

Student Spotlight: Bella Mirro

Bella Mirro (BE 2023)

Bella Mirro, a fourth year student in Bioengineering who also minors in Chemistry, spoke with 34th Street Magazine about her many roles at Penn, including being Co–President of Shelter Health Outreach Program (SHOP), a Research Assistant in lab of Michal A. Elovitz, the Hilarie L. Morgan and Mitchell L. Morgan President’s Distinguished Professor in Women’s Health at Penn Medicine, and a Penn Engineering Council Marketing Team Member. In this Q&A, she discusses her research in women’s health and her passions for accessible healthcare, serving Philadelphia’s homeless community, and good food.

Read “Ego of the Week: Bella Mirro” in 34th Street.

Penn Bioengineering Senior Discusses Remote Research Experience

Yi-An Hsieh (BE 2023)

Yi-An Hsieh, a fourth year Bioengineering student from Anaheim, California, worked remotely this summer on a team that spanned three labs, including the Kamoun Lab at the Hospital of the University of Pennsylvania. Hsieh credits her research on kidney graft failure with enriching her scientific skill set, exposing her to machine learning and real-time interaction with genetic datasets. In a guest post for the Career Services Blog, Hseih writes about her remote summer internship experience. “It showed me that this type of research energy that could not be dampened despite the distance,” she writes.

Read “Exploring How Amino Acid Polymorphisms Affect Graft Survival” in the Career Services Blog.