Protecting Pediatric Patients: Team Reel-IV Designs for Safer Care

For many hospitalized infants and children, an intravenous line is a critical part of care. But when that line becomes tangled, pulled or dislodged, the consequences can be painful, disruptive and potentially dangerous.

That problem became the focus for Team Reel-IV, a Bioengineering senior design team made up of Priya Agarwal (BE & Wharton ‘26), Anushka Gandhi (BE ‘26), Yerahm Hong (BE ‘26), Nicole Mirzaian (BE ‘26) and Ayma Waqar (BE & BioMed ‘26). Their device is designed to reduce accidental IV dislodgement in pediatric hospital settings, particularly neonatal intensive care units (NICUs) and pediatric intensive care units (PICUs).

Team Reel-IV presenting their work. From left to right: Nicole Mirzaian, Priya Agarwal, Anushka Gandhi, Yerahm Hong and Ayma Waqar.

The system automatically manages slack in IV tubing through a tension-sensing mechanism, allowing patients to move more naturally without placing dangerous tension on the catheter site. The goal is to improve patient safety, reduce interruptions in treatment and ease the burden on nurses who regularly reposition and untangle IV lines.

The project has already earned national recognition. Reel-IV placed second in the PennHealthX Venture Pitch Contest, second at the M&T Summit, received the Founder’s Award and an Honorable Mention at the TCU Values and Ventures Competition, and placed second at the University of Minnesota’s 25th Anniversary Design of Medical Devices Conference.

For Michael Siedlik, Lecturer in Bioengineering and one of the team’s faculty advisors, that recognition reflects the team’s commitment to understanding the problem before designing the solution.

“A critical component of Bioengineering senior design at Penn is that each team of students must identify a meaningful, real-world problem to be solved,” says Siedlik. “Team Reel-IV exemplifies the commitment to learning from nurses, doctors and patients.”

For the students, the project began with both personal connection and clinical observation. Several team members had close friends or family members whose babies spent time in NICUs, giving them a window into how overwhelming pediatric hospital environments can be for families.

That connection deepened as the team spoke with NICU and PICU nurses. They learned that IV dislodgement is not an occasional inconvenience, but a recurring problem nurses manage during routine care and patient movement. The team was also drawn to pediatric care because many medical devices are designed first for adults, then adapted for children.

Team Reel-IV from left to right: Yerahm Hong, Anushka Gandhi, Ayma Waqar, Priya Agarwal and Nicole Mirzaian.

“We did not want to build something purely technical for the sake of engineering,” says Waqar. “We wanted to work on a problem where even a small improvement could genuinely make hospital experiences safer and less stressful for children, families and healthcare workers.”

Siedlik says that the process of listening, learning and refining is central to senior design in Bioengineering. Reel-IV, he says, “continuously evolved their project throughout the fall semester until they settled on their final design solution.

Reel-IV required the team to work across technical development, clinical research, market analysis, business strategy, computer-aided design refinement, presentation development and outreach. Each part of the project depended on the others: clinical research helped define the need, prototyping and testing shaped the device, market analysis and business strategy clarified its path forward, and presentation development and outreach helped the team communicate the value of their work to clinicians, judges and potential partners.

That range of responsibilities made collaboration essential. Team members brought different strengths to the project, but the work had to move as one system. They regularly came together for testing sessions, design reviews and feedback discussions with clinicians, using each round of input to refine both the device and the broader strategy behind it.

“Because Reel-IV sits at the intersection of engineering, healthcare and entrepreneurship, we had to constantly communicate across different areas of expertise,” says Waqar.

For Siedlik, that ability to sort through feedback was one of the team’s most important areas of growth.

“A challenging part of entrepreneurship, and something that many students can initially struggle with, is identifying which external input is valuable feedback and which is just noise,” he says. “It was very exciting to see them become increasingly confident throughout the semester at navigating through that to ultimately arrive at their final, award-winning prototype design.”

One of the team’s biggest technical challenges was designing a system that could actively manage IV tubing tension without interfering with medication flow or creating additional safety risks. The students repeatedly tested tubing behavior, spool geometry, motor responsiveness and force thresholds to make sure the device responded appropriately without damaging tubing or affecting flow rates.

The process also taught the team to prioritize simplicity. As the project advanced, they narrowed their focus to the core problem: preventing dangerous line tension and dislodgement.

Team Reel-IV with their project. From left to right: Nicole Mirzaian, Yerahm Hong, Ayma Waqar, Anushka Gandhi and Priya Agarwal.

“One major lesson we learned is that good engineering is rarely about building the most technically complicated solution,” says Waqar. “It is about building something reliable, practical and usable in the real world.”

Siedlik was especially impressed by the team’s validation work, including usability testing, durability testing, quantitation of failure modes and evaluations of possible unintended consequences.

“I have been impressed by Reel-IV’s drive to rigorously validate their final device,” says Siedlik. “I expect them to be ready to test their device with patients soon, and I believe they are well-positioned because of the effort and intensity that they have put into their senior design project.”

Team Reel-IV in their graduation gowns, from left to right: Priya Agarwal, Anushka Gandhi, Ayma Waqar, Nicole Mirzaian and Yerahm Hong.

Reel-IV is not ending with the academic year. The team plans to continue developing the device through additional prototyping, clinical testing and, eventually, hospital pilot programs.

For Siedlik, Reel-IV represents something larger than a successful senior design project.

“To me, Team Reel-IV represents engineering with empathy,” he says. “I believe that as technological advances continue to grow exponentially, human connection and empathy will be more important than ever.”

That mindset is visible across the team’s work: in the clinical research that grounded the project, the technical design that made it functional, the business strategy that helped define its path forward and the communication that carried Reel-IV onto national stages.

The team began by listening carefully to patients, families and clinicians. They then translated that understanding into a biomedical engineering solution designed to improve safety, comfort and care.

“I am eager to see the impact they have,” says Siedlik, “and I am confident that their work will improve lives and communities.”

Bioengineering 2026 Graduate Awards

President & Provost’s Honor for Developing New Initiatives in Graduate & Professional Student Life

This award recognizes graduating students who have created lasting developments that enhance graduate and professional student life. Zhao was recognized for his extensive service and leadership through multiple roles within the Graduate and Professional Student Assembly (GAPSA) and on University committees, as well as his sustained advocacy for research students at Penn.


Outstanding Academic


Outstanding Research


Honorable Mention, Outstanding Research


Solomon R. Pollack Awards for Excellence in Graduate Bioengineering Research

The Solomon R. Pollack Award for Excellence in Graduate Bioengineering Research is given annually to the most deserving Bioengineering graduate students who have successfully completed research that is original and recognized as being at the forefront of their field.

  • Advisor: Dr. Chamith Rajapakse
  • Dissertation Title: Rapid, High-resolution, and Signal-efficient Methods for the Clinical Translation of Bone Magnetic Resonance Imaging

  • Advisor: Dr. Mike MItchell
  • Dissertation Title: Engineering targeted lipid nanoparticles for RNA delivery to the placenta

  • Advisor: Dr. Ravinder Reddy
  • Dissertation Title: Novel Metasurfaces for Mitigation of B1 Inhomogeneities in NOE and CEST MRI at 7T: Clinical Applications in White Matter Demyelinating Pathology

Knight-Hennessy Scholar

The Stanford University program provides up to three years of financial support for graduate study, along with global leadership training through a multidisciplinary cohort of scholars. Leung will pursue a Ph.D. in bioengineering at Stanford’s School of Engineering and School of Medicine. At Penn, she built Empathera, a startup focused on pressure ulcer prevention, revived Penn ADAPT and launched Enginuity, a platform that connects student engineers with people with disabilities to support community-driven assistive technology design. Her research on adaptive deep brain stimulation algorithms has also been recognized by Penn Bioengineering and at several conferences.


Graduate Research Fellowship Program

This fellowship program recognizes and supports outstanding graduate students in science, technology, engineering and mathematics fields who are pursuing research-based master’s and doctoral degrees. The fellowship provides three years of financial support, including an annual stipend and cost-of-education allowance, while helping prepare recipients to become leaders in research, teaching and innovation.

Scaling Student Innovation: Enginuity Powers Community-Driven Engineering

At the University of Pennsylvania, student-led projects through Penn ADAPT (Assistive Devices and Prosthetic Technologies) have demonstrated how engineering can move beyond the classroom to address real-world challenges, from assistive devices to clinical tools. But as those efforts grew, so did a fundamental constraint: connecting students with the communities and organizations who needed their skills.

Brianna Leung, a graduating M.S.E. student in Bioengineering and former president of Penn ADAPT, saw that gap firsthand. While student teams were eager to build and community needs were abundant, sourcing projects often required months of outreach, coordination and persistence. Through her work with community partners, including ongoing engagement with HMS School for Children with Cerebral Palsy, a Philadelphia-based school serving students with complex disabilities, Leung saw both the demand for assistive solutions and the barriers to accessing them.

In response, she helped develop Enginuity, a platform that allows community partners to post engineering challenges directly, connecting them with student teams more efficiently to address real-world needs.

Now, as Leung prepares to graduate, leadership of Enginuity will transition to Andrew Yao, a second-year in Bioengineering and vice president of Penn ADAPT. Yao will continue expanding the platform’s reach and impact. Together, their perspectives highlight both the platform’s origins and its next phase.


Q: During your involvement with Penn ADAPT what gaps did you start to notice in how projects were sourced or developed, and how did that lead to Enginuity?

The goal with ADAPT was always to use engineering as a force for change in Philadelphia. I’ve always preferred working on projects with a real-world end goal. When we have a student body that is skilled, well-resourced and eager to build, it doesn’t make sense to focus only on hypothetical problems.

We started reaching out to community partners, beginning with cold emails and early pilot projects. Over time, the number of potential projects began to outpace our capacity. That’s when we started thinking about how to make this kind of work more accessible. Enginuity grew out of that idea, as a way to build a more direct and scalable connection between student engineers and community needs.


Q: Enginuity allows organizations to post their own engineering challenges. What changes when the community defines the problems?

A huge part of engineering is listening and understanding a problem. The community knows best what it needs.

When organizations define their own challenges, students gain a much richer experience. You’re not just solving a predefined problem—you’re translating real-world constraints, user needs and qualitative feedback into something tangible. That process builds both technical skills and empathy.


Q: What are the biggest barriers today for students who want to engage in real-world engineering problem-solving, and how does Enginuity address them?

At Penn, everyone is incredibly busy. From my own experience, it took a full summer of emails, meetings and coordination to establish our first collaboration. Building those relationships can take years, and most students don’t have the time to navigate that process.

Enginuity simplifies that by creating a centralized space where community members can submit project ideas. Instead of starting from scratch, students can focus on the work itself, connecting more quickly and collaborating more effectively.


Q: Many student projects are tied to a semester or a single team. Why was it important to build a platform instead of focusing on individual projects?

We’re hoping to generate more projects overall. Through ADAPT, we saw that there was a lot of need, but not enough people available to handle the outreach and logistics.

By building a platform, we can remove some of those barriers and allow more students to get involved. The goal is to make it easier for engineers to focus on solving problems rather than finding them.


Q: How do you see Enginuity changing the relationship between Penn and the Philadelphia community?

Penn is an incredibly well-resourced institution, and ADAPT has benefited from support across labs, departments and staff. There’s a real opportunity to use those resources to make a meaningful impact in Philadelphia.

At the same time, Philadelphia has the highest per-capita disability rate of any major U.S. city. As engineers, we have a responsibility to contribute where we can. I hope Enginuity helps build a more consistent and dependable connection, so community members feel they can turn to us for support.


Q: If Enginuity succeeds at the scale you envision, what could it change about how engineering solutions are developed and shared?

Student engineers occupy a unique space, especially in areas like assistive technology. Many devices for specialized needs are either unavailable or extremely expensive.

Every week, through my work with HMS School, I see devices that cost hundreds of dollars but could be built for a fraction of that. That gap highlights both the challenge and the opportunity. I hope Enginuity can mobilize a broader network of student engineers to help fill those gaps and expand access to these kinds of solutions.


Q: How has building Enginuity shaped the way you think about engineering and your role as a bioengineering student?

Building Enginuity has been an exploration of how projects generate learning. In traditional coursework, there are clearly defined skills and relatively low stakes. However, with Enginuity, real-world problems can be solved in many different ways, and students may develop completely different technical skills working on the same challenge. At the same time, the stakes are higher. Delivering a solution in a real-world setting and maintaining relationships with our partners requires follow-through, and that can be difficult to guarantee. These questions, how to structure projects, how to support students and how to ensure meaningful outcomes, have shaped how I think about engineering as both a technical and systems-level discipline.

Developing the platform also required thinking about accessibility from the start. We worked to ensure the site is usable for individuals with disabilities, incorporating features such as screen-reader compatibility, adjustable text and clear navigation. In that sense, Enginuity is not only a tool for engineering projects, but an engineering project itself.


As Enginuity continues to grow, its long-term impact will depend on sustained student leadership. With Leung graduating, that responsibility will shift to Andrew Yao (BE’28), vice president of Penn ADAPT, who has been involved in the organization’s projects and outreach.

Yao sees Enginuity not only as a way to expand access to engineering projects, but also as an opportunity to strengthen connections between students and the communities they aim to serve.


Q: What excites you about taking over leadership of Enginuity?

I’m excited to continue working with community partners and expand ADAPT’s outreach. We recently showcased Enginuity at the Philly Maker Faire and received a lot of positive feedback, which showed there’s a real need for this kind of platform.

I’m looking forward to building on what Brianna started, connecting organizations and individuals with student problem-solvers to create a greater impact in the Philadelphia community.


Q: How does Enginuity shape the way students approach engineering problems?

It helps keep the focus on the end user. As engineers, it’s easy to get caught up in the technical side and lose sight of whether a solution is actually practical.

On one of my projects, we initially designed a robotic system to assist surgeons, but after speaking with clinicians, we learned it wouldn’t be feasible in practice. That kind of feedback is critical, and Enginuity encourages more of those conversations early in the process.


Q: Where can community partners go to submit a project, and what information do they need?

Community partners can submit projects through the Enginuity page on the Penn ADAPT website or contact us directly by email (pennadapt@gmail.com). We ask for a description of the problem, and while additional materials like images or videos are helpful, they’re not required.

We’ve designed the platform to be accessible and easy to use, so partners don’t need a technical background to participate.


As Enginuity expands, it reflects a broader shift in how engineering education and practice intersect, not only building solutions, but building the pathways that make those solutions possible.

Rose Undergraduate Research Award Recipient Yerahm Hong Q&A

The Rose Undergraduate Research Award, administered by Penn’s Center for Undergraduate Research and Fellowships (CURF), recognizes outstanding and highly original research projects completed by graduating seniors under the guidance of Penn faculty. In this Q&A, Yerahm Hong (BE’26), a 2026 award recipient, shares her research journey and reflects on the work behind the award.

Can you describe your research project and its significance in terms a general audience can understand?

My project aims to assess the effectiveness of an antisense oligonucleotide (ASO) gene therapy for KCNC1-related developmental and epileptic encephalopathy (DEE). Pediatric patients with these rare genetic disorders suffer from spontaneous seizures, developmental delays, and intellectual disabilities, all deeply affecting their quality of life and the lives of their families. In these disorders, the body is making a protein that doesn’t work correctly, which causes misregulation of the brain’s electrical signals. The ASO therapy is designed to go into the cells and “intercept” the genetic instructions, preventing the faulty protein from being made in the first place. By testing this therapy in a mouse model, we’re moving closer to a cure in a world where current options like medications, special diets, and surgery remain limited in their effectiveness.

What problem does your research aim to address, and why is it important?

We’re addressing the lack of targeted treatments for rare genetic epilepsies. We’ve shown promising preliminary results for this ASO, which opens doors to potentially effective therapies for clinical trials.

What drew you to this research topic and working with Ethan Goldberg, Associate Professor of Neurology?

I’ve worked with Dr. Goldberg since the summer of my freshman year. Taking “Introduction to Brain and Behavior” as an elective sparked a curiosity for neuroscience that I decided to explore in the lab. Over the last few years, I’ve worked on various projects investigating the mechanisms of pediatric epilepsy through mouse models.

Why did you transition to this specific project?

I started this project in the summer of my junior year because I wanted to explore translational research. Since I had already contributed to the characterization of the mouse model for KCNC1-related DEE, it made sense to transition to exploring this specific therapeutic approach.

What was your specific role in the project?

My role involved injecting the ASO for each cohort of mice and conducting survival and behavioral studies to see how well the therapy worked. Currently, I’m collaborating with other research scientists and mentors in the lab to move the project forward. 

Was there a particularly challenging or rewarding moment in your research experience?

Recently, I achieved an interesting result quantifying the level of Kv3.1 protein knockdown by the ASO. The Western Blot experiment, a lab technique that separates proteins by molecular weight, was not guaranteed to work because it required many extensive steps. Completing it without mistakes with the help of my mentor was a very rewarding moment.

What has this experience taught you about the nature of research?

It taught me that research requires an enjoyment of the troubleshooting process. The attention to detail required to execute experiments effectively is a skill I hope to continue building throughout my career.

How did working with Ethan Goldberg, Associate Professor of Neurology, shape your experience?

Dr. Goldberg cultivated a lab environment conducive to learning, mentorship, and independence. He has been a kind mentor and role model who invested in me both professionally and personally. I’m very fortunate to have had this opportunity throughout my undergraduate years. I also deeply appreciate the daily mentorship of Sophie Liebergall, MD-PhD Candidate at University of Pennsylvania School of Medicine, and Dr. Kelly Markwalter, Postdoctoral Research/Clinical Fellow at the Children’s Hospital of Philadelphia. 

What does receiving the Rose Award mean to you?

I am profoundly humbled and encouraged by this recognition. Receiving this award is a testament to the wonderful work of my mentors in helping shape who I am as an aspiring physician-scientist. Working with people who are genuinely passionate about what they do is contagious.

What advice would you give to students who are just getting started with research?

Don’t give up! Enjoy the process and take advantage of the resources available at Penn. The time scale at which biomedical research moves is far beyond your time here, so it’s important to put things into perspective as you explore.

How has this experience influenced your future goals?

Being in a great research environment has given me a strong desire to pursue the physician- scientist path. Through an MD-PhD, I hope to gain the skills I need to make great research ideas into a reality. I’ve been bitten by the science bug, and I hope that I can channel this energy to advancing the latest neurotechnologies through research.

Designing for Real-World Impact: Bioengineering Students Drive Assistive Technology Projects at Penn

In the operating room, every second counts. As a procedure ends, the surgical team must account for every instrument used, which can sometimes consist of one hundred individual tools. The process is manual and time-consuming, but critical to patient safety.

Penn ADAPT club representatives during the club fair to recruit new members. [left to right] Suhani Patel (BE ’26); Jonathan Largoza, ADAPT Co-President (BE ’27); Ryan Liu, ADAPT Co-President (LSM ’27) and Iris Wong (BE ’27).

At the University of Pennsylvania, students in Penn ADAPT, a student-led organization focused on assistive technology and medical device design, are working to streamline that process. This year, the organization is supported by faculty advisor Michelle Johnson, Associate Professor in Physical Medicine and Rehabilitation, with secondary appointments in Bioengineering, and Mechanical Engineering and Applied Mechanics. Open to students across the University, the group brings together members from Penn Engineering, the College and Wharton to design solutions for real-world challenges. Among them are Co-President Jonathan Largoza (BE’27) and Vice President, Andrew Yao (BE’28), two Bioengineering students contributing to projects that reflect both the technical depth and interdisciplinary nature of the organization.


Yao has spent the past two years working on a surgical tool-checking system designed to assist operating room staff. The goal is to reduce the time required to manually count instruments while maintaining accuracy in a high-stakes environment.

 [left to right] Andrew Yao (BE ’27) and Abdullah Goher (CIS ’27) shadowing in the OR.

“In the operating room, you typically have a nurse or a nurse technician who counts instruments before and after each surgery,” Yao explains. “And depending on the surgery… it can take a while to count, anywhere from like 10 to 15 minutes.”

The team’s approach combines mechanical design, electronics and computer vision. A mounted system captures images of the sterile field, while a machine learning model identifies and counts instruments in real time. Building that system requires more than writing code. It means understanding how each component interacts within a larger system.

“Even once we have the computer vision model working, that’s not enough,” Yao says. “Having to integrate that within a new subsystem is always a challenge… how are we going to outsource the computing… are we going to connect to the Wi-Fi… are we going to have to use AWS to run the model?”

One of the biggest obstacles was data. Existing image datasets did not reflect how instruments appear during surgery, often stacked closely together rather than laid flat. To address this, the team reached out to clinicians at Penn Medicine and began building their own dataset.

“We went in over the summer… and took pictures of different orientations of instruments,” Yao says.

For Yao, the project extends concepts introduced in Bioengineering coursework into a more complex, real-world setting.

“In class, you might get to the finished vision model,” he says. “But then having to integrate that within a new subsystem is always a challenge.”


While Yao’s work focuses on clinical environments, Largoza’s projects center on community-based partnerships, particularly with the Pennsylvania Center for Adaptive Sports (PCAS).

One of his earlier projects addressed a practical challenge faced by adaptive cycling programs. Riders require customized pedals, which must be swapped frequently depending on the user. The process can be time-intensive and, if done incorrectly, can damage equipment.

Bikes from the PCAS program.

“A bike will get used by four, five, six different people,” Largoza says. “That’s a lot to manage for the volunteers… and they’re not mechanical engineering experts.”

His team developed a quick-release pedal system inspired by hose coupling mechanisms, allowing for faster and more reliable exchanges.

“It’d be a one-time installation, and we wouldn’t have to further worry about it,” he explains.

The project involved multiple rounds of computer-aided design (CAD), prototyping and testing, with plans to explore stronger materials like carbon fiber and real-world stress testing.

“We’ve had several iterations of CADing and 3D printing… and we’re still optimizing,” Largoza says.

Paavni Suyal (BE ’29) working on accessible footwear design.

More recently, Largoza has been working on a project designed to help athletes with limited use of one arm independently secure their footwear. The team is exploring mechanisms including velcro and even magnets that allow for one-handed tightening, drawing inspiration from existing systems while adapting them for accessibility.

“We want that sort of sense of autonomy and independence… but it’s very difficult to do that with one hand,” he says.

The design process has been iterative, moving through multiple concepts and refining based on usability and durability.

“It’s a very reiterative process… trying to optimize those CADs.”


For both students, Penn ADAPT provides an environment where classroom concepts are applied in tangible ways. Largoza points to early exposure to design tools through coursework as foundational to his work.

“BE1000 [Introduction to Bioengineering] actually gave me my very initial exposure to CAD… and then BE3090 [Bioengineering Modeling, Analysis and Design Laboratory I] and BE3100 [Bioengineering Modeling, Analysis and Design Laboratory II]… taught me the skills I needed for SOLIDWORKS.”

Yao highlights how coursework in computing and electronics translates directly into project work.

“ENGR 1050 [Introduction to Scientific Computing]… introduced me a lot to image classification, AI models, and neural networks,” he says. “In the context of ‘how can we apply this to an actual surgical dataset’… that’s kind of an extension of what we learn in class.”

At the same time, both emphasize that Penn ADAPT goes beyond technical skill-building. Projects require integrating multiple disciplines and adapting to real-world constraints.

“I’ve learned a lot about how mechanical and electrical work very, very closely… and then how software integrates into that is also a challenge,” Yao says.


Penn ADAPT’s interdisciplinary structure shapes both the design process and the solutions themselves. Students from across the University contribute different technical backgrounds and perspectives, often learning from one another in real time.

“It’s great having an interdisciplinary team,” Largoza says. “People… bring a very different perspective to the group.”

In some cases, those perspectives are directly tied to lived experience. On Largoza’s current project, a team member with a prosthetic leg who previously participated in adaptive sports contributes firsthand insight into user needs.

“That was a great addition to the team because you definitely get more of the user perspective,” he says.

For Yao, collaboration across disciplines enhances both leadership and learning.

“I feel like I’m constantly learning,” he says. “It’s more just like a whole team kind of collaborative project at the end of the day.”

The organization’s structure reflects that approach. Members work in project teams with designated leads, while the broader group shares feedback through design reviews and regular check-ins.


Since returning to full operations in 2022, Penn ADAPT has expanded significantly, growing in both membership and project scope. For Largoza, that growth signals the organization’s trajectory.

“When I joined… [there were] only three projects,” he says. “But now we have eight different projects… so I think our growth is a great indicator for where the club is headed.”

Yao sees that growth reflected in the organization’s increasing impact, both locally and beyond.

“The growth of our club has also expanded the impact we’ve had in the Philadelphia community,” he says.

As projects mature, teams are moving beyond early prototypes toward testing, deployment and broader implementation. One such project, their low-cost switch interface, has been brought to schools and disability organizations internationally through emerging global partnerships.

“You might see these projects as a small-scale thing,” Yao says. “But once they develop into mature projects and products, they can create such a big impact for different communities.”


With projects spanning clinical environments and community partnerships, Penn ADAPT offers Bioengineering students a space to explore the full range of their field. For Largoza and Yao, that means not only building technical skills, but also contributing to solutions that extend beyond the classroom.

“I personally saw the tangible impact… different devices might have on people,” Yao says. “And that connection is really big to me.”

2026 Bioengineering National Science Foundation Graduate Research Fellowship Program

The National Science Foundation (NSF) is an independent federal agency that supports fundamental research and education across all fields of science and engineering. Established to advance the progress of science and strengthen national health, prosperity and security, the NSF funds early-stage, high-impact research that drives discovery and innovation. Its investments help develop new knowledge, train the next generation of scientists and engineers and expand the frontiers of what is possible.

Among the NSF’s most prestigious programs is the Graduate Research Fellowship Program (GRFP), which recognizes and supports outstanding graduate students at the beginning of their research careers. The fellowship provides three years of funding, including a stipend and tuition support, and is awarded to individuals who demonstrate both strong intellectual merit and the potential for broad societal impact. By investing in emerging researchers, the GRFP plays a critical role in shaping future leaders in science and engineering.

Within the University of Pennsylvania, several students affiliated with Bioengineering have been selected as 2026 National Science Foundation Graduate Research Fellowship Program awardees. Their recognition reflects both individual achievement and the strength of the Bioengineering community at Penn Engineering.

Congratulations to these students on this accomplishment.

  • Giana Vitale
  • Sylvia Cho
  • Roy Chen
  • Cayman Matson
  • Alexandra Dolynuk
  • Tal Dassau
  • Sasha Shefter
  • Emily Fitzgerald
  • Lindsay Gallgher
  • Gene Weng
  • Chloe Connolly
  • Julia Patterson
  • Natalie Calahan
  • Evangeline Meyler
  • Cameron White
  • Aisha Mansoor
  • Lucy Park
  • Songman Li
  • Sara Hunihan
  • Rene DeBrabander
  • April Guo-Yue
  • Shiny Shen, will be attending the Duke University Biomedical Engineering Ph.D. program.
  • Anthony Tukanowicz-Hassett, will be attending the Massachusetts Institute of Technology (MIT) Biological Engineering Ph.D. Program.
  • Emily Zhang, will not to pursue graduate studies at this time, and will be joining Epic post grad as a Technical Solutions Engineer.
  • Brianna Leung, will be attending Stanford University’s Bioengineering Ph.D. program.
  • Ryann Joseph, currently pursuing a Ph.D. in Bioengineering at Harvard.
  • Sophia Klessel, currently pursuing a Ph.D. in Bioengineering and Biomedical Engineering at The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University

2026 Undergraduate Awards for Bioengineering Students

Each spring, awards are given to undergraduate students in the School of Engineering and Applied Science in recognition of outstanding scholarly achievements and service to the School and University community.

Read the full list of Bioengineering undergraduate award winners below.


The Wolf-Hallac Award

Shiny Shen

This award was established in October 2000 to recognize the graduating female senior from across Penn Engineering’s departments who is seen as a role model, has achieved a high GPA (in the top 10% of their class), and who has demonstrated a commitment to school and/or community.

Maddie Magee Award

The Maddie Magee Award for Undergraduate Excellence was established to remember and celebrate Madison “Maddie” N. Magee, MEAM BS ’21, BE MS ’21. The award is given annually to a Penn Engineering senior who best exemplifies the energy, enthusiasm and excellence that was Maddie.

“I am deeply honored to receive the Madison Magee Award for Undergraduate Excellence, and I will carry forward her legacy of energy, enthusiasm, and
dedication in everything I pursue beyond Penn Engineering.”

-Sage Leland

Sage Leland

The Hugo Otto Wolf Memorial Prize

This prize is awarded to one or more members of each department’s senior class, distinguishing students who meet with great approval of the professors at large through “thoroughness and originality” in their work.

Ben Nachod

“I would like to thank all of the wonderful BE professors and lab instructors who have supported and mentored me throughout the past four years. I am also deeply grateful to Dr. Mitchell and Dr. Momin for their guidance and support as research mentors, as well as to all of the members of the Mitchell and Momin labs.”
-Ben Nachod

The Bioengineering Student Leadership Award

This award is given annually to a student in Bioengineering who has demonstrated, through a combination of academic performance, service, leadership, and personal qualities, that they will be a credit to the Department, the School, and the University.

Yerahm Hong

“I had never imagined just how wonderful a community BE would be when I first arrived at Penn–from the faculty, BE lab staff, my fellow students, and alumni, I’ve found my family right here in BE labs. Thank you to all of my BE professors (and the lab instructors and staff, especially) for their contributions to my growth in the classroom and beyond. I’m very grateful and honored to represent BE!”
– Yerahm Hong

The Herman P. Schwan Award

The Herman P. Schwan Award was established by the faculty of the Department of Bioengineering as an enduring tribute to their colleague and friend, in honor and recognition of his outstanding achievements in Bioengineering, and in commemoration of the receipt of his honorary Doctor of Science degree in 1986 from the University. This award is given each year to a graduating senior who, in the opinion of the faculty, has demonstrated the highest standards of scholarship and academic achievement.

“Thank you to the Bioengineering faculty, mentors, and classmates who made my time at Penn truly special. Whether it was late-night study sessions before exams or working together on research projects, your support shaped my learning and experience. I feel very lucky to be part of such a caring and inspiring community!”
-John Kim

Penn Engineering Exceptional Service Award

This award recognize students for their outstanding service to the University and their larger communities.

“I’m so grateful to be given the chance to serve as both a mentor and a TA throughout my time here at Penn!”
-Yash Rajpal

Yash Rajpal
Austin Wei Zhuang

“I would like to thank all my BE professors for giving me the opportunity and knowledge to serve as a TA and mentor for others.”
-Austin Wei Zhuang

Albert Giandomenico Award

The Bioengineering Department also presents a single lab group with the Albert Giandomenico Award which reflects their “teamwork, leadership, creativity, and knowledge applied to discovery-based learning in the laboratory.”

What Makes a Discovery Matter?

A brilliant idea is just the beginning.

But between the lab bench and the lives it could change, there’s often a wide and uncertain gap. Bridging that space takes more than good data, it takes a story that resonates beyond the research community.

That’s what Practice Associate Professor Katie Reuther, PhD, MBA (Department of Bioengineering and Center for Health, Devices and Technology, University of Pennsylvania, Philadelphia, PA), challenges academic researchers to embrace in her new Nature Biotechnology article, co-authored with Darren Cooke (University of California, Berkeley, Berkeley,) and Mark Kessel (Consultant, New York, NY).At its core, the piece isn’t just about pitch decks. It’s about showing the world, clearly and credibly, why your science matters now.

Question: What’s at stake when researchers don’t learn to communicate the value of their science early on? What do we risk missing out on and who do we fail to reach?

Dr. Reuther: When researchers do not learn to effectively communicate the value of their work, the primary risk is that groundbreaking innovations with potential to impact patients may remain confined in academia.  Effective science communication helps build trust and credibility by making complex science accessible to a wide audience, such as investors, partners, and the public, enabling them to see its potential impact. These elements are a critical starting point for eventually securing the necessary financial resources and support to navigate the expensive, long, and risky path from the lab bench to the market. While strong communication won’t guarantee investment or make a bad idea viable, without it, the conversation won’t even begin.

The article outlines the mechanics of building a compelling life sciences pitch. But the bigger message is clear: the future of translational research depends not only on what you discover, but on how effectively you can make others care.

Question: What do you see as the biggest disconnect between the way academics communicate their research and what’s needed to mobilize real-world support?

Dr. Reuther: Academics and scientists are trained in communicating their research findings to scientific experts. While this is critically important, what’s needed to mobilize support from investors and other partners who can help make these ideas a reality is different. It relies not only on the demonstration of technical achievements but also the communication of the real-world impact and value of the work. While it may seem intuitive, researchers often overlook the need to clearly define the problem they are solving and to articulate a compelling value proposition that differentiates their idea from the status quo. Investors and partners are focused on future commercial value, not complex scientific findings. I do believe that academics can learn how to communicate the business viability of their work and we have proven this in our own work at Penn Health-Tech.

From IP strategy to reimbursement pathways to articulating a problem that truly demands a solution, Reuther and her co-authors give researchers the scaffolding to build a narrative investors, partners—and ultimately, patients—can believe in.

And in a field where even the most impactful technologies can falter in the shadows, being able to clearly tell the story of why your work matters is no longer optional. It is now a necessity.

Question: Do you think academic training does enough to prepare scientists to communicate the real-world value of their work? What needs to change?

Dr. Reuther: As we’ve discussed, most academic training is heavily focused on communicating research findings to scientific experts. However, over the past several years, greater attention on business communication has been given due to the expectation that federally-funded academic innovations should eventually translate into real-world impact. Many universities (including Penn) and federal agencies (including the NIH and NSF) have fostered educational programs to help researchers learn about business fundamentals and articulate and validate their work’s potential value. We need to continue to push to increase awareness of these programs and make them accessible to those who need it.

Read the article:
Reuther, K.E., Cooke, D. & Kessel, M. Innovation to investment: how to build your first life sciences pitch deck. Nat Biotechnol 43, 1204–1207 (2025).
🔗 Read here

Nick Marzolini Named 7th Recipient of the Michael S. Brown Fellowship

Penn MD/PhD student recognized for outstanding potential as a physician–scientist developing targeted genetic therapies.

Nick Marzolini, recipient of the 7th annual Michael S. Brown Fellowship, is an MD/PhD student in Penn’s Medical Scientist Training Program.

Nick Marzolini, an MD/PhD student in the Medical Scientist Training Program (MSTP) at the University of Pennsylvania, has been named the 7th annual recipient of the Michael S. Brown Fellowship, awarded each year to one MSTP student for “outstanding potential as a physician–scientist.”

“When I learned of my receipt of this award, I felt largely honored to be considered for it amongst such a competitive applicant pool,” says Marzolini. “My MSTP classmates are extraordinarily bright, talented, and hard-working, and it is incredibly validating to know that the MSTP awards committee feels similarly about me.”

Honoring a Legacy of Discovery

The fellowship was established by Michael S. Brown (C ’62, M ’66, HON ’86), a Penn alumnus and Nobel Laureate in Physiology or Medicine. Brown, along with colleague Joseph Goldstein, received the 1985 Nobel Prize for discoveries in cholesterol metabolism that led to life-saving treatments for heart disease. His eponymous fellowship continues that spirit of scientific innovation by supporting Penn MD/PhD students pursuing transformative biomedical research.

“This recognition validates that my research has true clinical implications,” says Marzolini, “underscoring its enormous therapeutic potential.”

Pioneering Targeted Gene Therapy

Marzolini’s research focuses on targeted gene therapy, developing lipid nanoparticles (LNPs) loaded with DNA to deliver therapeutic genes directly to diseased organs. His goal is to create treatments for conditions that currently have no cure.

“With this technology, I hope to deliver therapeutic genes implicated in diseases across the body — including the lungs (e.g., pulmonary hypertension) and central nervous system (e.g., Alzheimer’s disease),” he explains. “If successful, a single safe injection will bring hope to where there was previously none.”

Lipid nanoparticles have become a cornerstone of modern biomedicine, serving as delivery vehicles for mRNA vaccines and genetic medicines. Marzolini’s work builds on that foundation, exploring how DNA-bearing LNPs can target tissues with precision, paving the way for safer and more effective therapies.

Mentorship and Collaboration

Marzolini conducts his research in the Brenner Bioengineering Lab, led by Jake Brenner, MD, PhD, a member of the Bioengineering Graduate Group Faculty, whose team studies advanced delivery systems for treating lung injury and inflammation.

“My PI, Dr. Jake Brenner, affords me scientific freedom to explore my own research avenues while harboring a collegial lab culture,” says Marzolini. “My colleagues provide me with considerable guidance. And the MSTP works tirelessly to ensure my growth as a physician–scientist.”

He emphasizes that his success is the product of a shared effort. “Mentorship and collaboration are requisite in science,” he says. “My success is simply the sum of all the mentoring, help, and kindness I have received from others along the way.”

Looking Ahead

As he continues toward his dual degrees — a PhD expected in 2028 and MD in 2030 — Marzolini says the fellowship will be instrumental in advancing his next phase of research. “This fellowship will undoubtedly prove pivotal as I take the next steps toward my goal of translating our new technology into a viable therapeutic,” he says.

For Marzolini, the recognition is both a milestone and a motivator. “I am extremely grateful for this opportunity to further pursue my scientific and clinical passions, which I find only burn brighter the closer I get to achieving them.”

Penn BMES Wins National Commendable Achievement Award

Celebrating Student Leadership and Community in Bioengineering

The University of Pennsylvania’s chapter of the Biomedical Engineering Society (BMES) has been recognized nationally with the Commendable Achievement Award, the second-highest honor given to student chapters by the national BMES organization. The award celebrates Penn BMES’s exceptional efforts to build community, foster professional growth, and expand the reach of bioengineering at Penn and beyond during the 2024–2025 academic year.

Kyulee Kim and Krish Modi accept the Commendable Achievement Award on behalf of the Penn BMES chapter.

BMES leaders Kyulee Kim (BSE and MSE, Bioengineering) and Krish Modi (BSE and MSE, Bioengineering) accepted the award on behalf of the chapter at the BMES Annual Meeting, held October 8–11, 2025, in San Diego, California.

“Being part of BMES has been one of the most meaningful parts of my time at Penn,” said Modi, current President of Penn BMES. “It’s given me the chance to connect with students, faculty, alumni, and industry professionals and to help make our department feel more connected. Receiving the Commendable Achievement Award is an exciting recognition of all the energy and care our team puts into building that community.”

“We were able to gradually expand our impact across the school these past few years,” added Kim, senior advisor and former president of Penn BMES. “Being recognized as the best club of the year by Penn Engineering and now by BMES nationally affirms that our efforts have been meaningful for the community and motivates us to continue making an impact.”

From Left to Right: Saw Nwe, Anya Mittal, Emily Jiang, Krish Modi, Jonathan Largoza, Yifan Zhai, Alekha Malhotra

Elevating the Bioengineering Community

Penn BMES serves as the undergraduate professional society for the Department of Bioengineering, acting as a liaison between faculty and students while offering opportunities for professional development, wellness, and outreach. Each semester, the club hosts a robust calendar of events designed to connect students across class years, support academic success, and explore career pathways in bioengineering.

Highlights from Fall 2025 include:

  • Mentorship Kickoff with the Graduate Association of Bioengineers (GABE) – fostering connections between undergraduate and graduate students.
  • Alumni Dinner at the Singh Center – bringing together alumni, students, and faculty for networking and shared conversation.
  • WUHC x BMES x PUCS Research Showcase – highlighting undergraduate research across engineering and the health sciences.
  • ADAPT x BMES High School Engineering Event – introducing local high school students to bioengineering through hands-on activities.
  • Faculty Lunch Series – informal gatherings with Penn Bioengineering professors to discuss research and career advice.
  • Wellness and study break events, including School Supply Decorating and Winter Wellness, to help students recharge throughout the semester.

Through these events and collaborations, BMES continues to strengthen the sense of belonging within the Penn Bioengineering community and inspire future leaders in the field.

Kim reflects, “When I first joined BMES my freshman year, I had no idea it would be such a significant part of my Penn experience. To me, at first, BMES was simply a club that met once a week and hosted occasional bioengineering events. However, as I spent more time in the club, I truly started to think more deeply about what Bioengineering students need – stronger sense of community, more opportunities for learning outside the classroom, and clearer understanding of  how we as bioengineers can make an impact on broader communities like greater Philadelphia.”

Representing Penn on the National Stage

At the BMES Annual Meeting, members Bioengineering community represented the department as student ambassadors, hosting a booth to share information about their chapter’s initiatives and connect with peers from around the country.

From left to right: Emily Jiang, Yifan Zhai, Emily Zhang, Saw Nwe, Krish Modi, Jonathan Largoza, Yashna Gupta, Iris Wong, Alekha Malhotra, and Anya Mittal.

Penn’s delegation included:

  • Undergraduate students: Krish Modi, Ian Peng, Jonathan Largoza, Emily Jiang, Saw Nwe
  • Master’s students: Yixiao Zhao, Korey Patwari, Akshaya Biju
  • PhD students: Amanda Murray, Hannah Yamagata, Renee-Tyler Morales, and Emily Lin

The Ambassadors were advised by Jina Ko, Assistant Professor in Bioengineering, who supported their participation at the conference.

Alumni & Friends Gathering

Penn Bioengineering also hosted an Alumni & Friends Gathering on Wednesday, October 8, at Meze Greek Fusion in San Diego, offering an informal space for alumni, students, postdocs, and faculty to reconnect during the meeting.

As the chapter continues to grow, Penn BMES remains dedicated to fostering community, advancing professional development, and celebrating the creativity that defines bioengineering at Penn.

Learn more about Penn BMES.