Susan S. Margulies, Ph.D., currently professor of bioengineering at the University of Pennsylvania, has been named the Wallace H. Coulter Chair of the Department of Biomedical Engineering at Georgia Tech/Emory University and the Georgia Research Alliance Eminent Scholar in Injury Biomechanics. Her appointment begins August 1.
Dr. Margulies’s history at Penn goes back to 1982, she arrived at Penn to earn a master’s degree in the bioengineering department, followed by her Ph.D. in 1987. In 1993, she returned to Penn as an assistant professor, with promotion to associate in 1998 and full professor in 2004.
“At GT-Emory BME I will lead 72 faculty and 1,500 students, and look forward to creating impact in a new environment,” Dr. Margulies says. “As a Penn alum and emeritus faculty member, my ties here run deep. I look forward to keeping in touch.”
Dr. Margulies’s has deep roots at Penn indeed, and her accomplishments are broad and distinctive. They include:
Creating new faculty mentoring programs across the university, including the Penn Faculty Pathways program
Teaching a broad number of courses spanning Introduction to Bioengineering through to Pedagogical Methods in Engineering Education
Establishing many new research initiatives that extended into Children’s Hospital of Philadelphia and significant relationships with industry
Activity with several national leadership positions
On Dr. Margulies’s departure, David Meaney, the department chair, said, “We will miss Susan’s wisdom and insight, but we wish her the very best in her next step.”
by Kaila Helm, Biological Basis of Behavior ’20; and Hope McMahon, Chemical and Biomolecular Engineering ’18
During the seven-hour drive from Mole National Park to Kumasi, students take the opportunity to catch up on their Zs.
David Issadore, a faculty member in the Department of Bioengineering at the University of Pennsylvania teaches an engineering course ENGR566 – Appropriate Point of Care Diagnostics. As part of this course, he and Miriam Wattenberger from CBE, have taken nine Penn students, most of them majoring in Bioengineering, to Kumasi, Ghana, to study the diagnosis of pediatric tuberculosis. While in Ghana, these students are blogging daily on their experiences.
This morning we ended our three-day trip to Mole National Park. For breakfast, we had omelets and toast with some spread for bread and jam paired with our usual combination of coffee, tea, or Milo (Australian chocolate milk). After packing up the bus with water in hand, we set out for another long car ride (but not before seeing some elephants swimming in the lake and baboons leisurely walking around the property). On the way back to Kumasi, we stopped at a rest stop to use the washroom and have another delicious Ghanaian meal. Some ate jollof rice and chicken; others were more adventurous with goat and fufu with peanut soup. After our long journey, we arrived back to KNUST, pleasantly surprised by the petrichor and rainbows after a brief burst of rain.
A few of us decided to take a walk around campus, stopping by a convenience store and walking around the Guss Hostel. When we arrived back at KCCR, we soon learned we would be joining Dr. Ellis for the evening. After greeting Dr. Ocek Eke, we all ran to our rooms to quickly change. We headed to dinner. There we tried different combinations of smoothies, with a fútbol game projected on a screen in the background. We ate a lot: chicken kebabs, gizzard, liver, joloff rice, fish, and even some French fries. To end our jam-packed day, we headed back to KCCR, greeted at the door by a praying mantis.
by Jason Grosz, Bioengineering ’19; and Ethan Zhao, Bioengineering ’19
Penn students have a close encounter with two friendly elephants in Mole National Park. (Left to right: Jason Grosz, Kate Panzer, Hope McMahon, Kaila Helm, Danielle Tsougarakis, Kathleen Givan, Katharine Cocherl, Nana Yaa, Ethan Zhou, David Pontoriero, Benjamin)
David Issadore, a faculty member in the Department of Bioengineering at the University of Pennsylvania teaches an engineering course ENGR566 – Appropriate Point of Care Diagnostics. As part of this course, he and Miriam Wattenberger from CBE, have taken nine Penn students, most of them majoring in Bioengineering, to Kumasi, Ghana, to study the diagnosis of pediatric tuberculosis. While in Ghana, these students are blogging daily on their experiences.
Today we set out on a 7 a.m. morning safari drive in Mole National Park. We rode on seats built on the roofs of Jeeps and drove along dirt roads dodging trees and spotting animals, such as cobs and wart hogs. A safari guide accompanied us on the roof to give directions to the driver, and the guide carried a large rifle in case an encounter with an animal went south. The highlight of the safari was running into two elephants right outside a building complex in the park. We saw two young males, one of which visited so often that park employees had named it Nash, and they were feeding on the wild mint plants that grew in the park. The guides told us that there were many such frequent visitors and that many of the elephants were named, a testament to how cordial the relationship between the park and the elephants was. They suspected that the elephants were just as curious of us as we were of them — as soon as we left, the elephants left the building complex as well. By the time the safari was over, it was around 11, and after lunch, we jumped into the pool as a reprieve from the blistering 100°F weather.
Local members of the Bmognorie village in Mole perform a traditional dance.
After lunch we visited a traditional African village named Bmognorie near Mole National Park. The village had a population of around 420 people who all lived in mud huts. Polygamy is practiced in the village, although monogamy is more common, and most families have around ten children. Our tour guide told us about life in the village and demonstrated how the villagers make shea butter, which can be used as a skin cream. He also said that sick villagers must travel on the back of a motorbike or bicycle for 30 km to reach the nearest clinic. The nearest hospital was 40 km away. After the shea butter demonstration, we watched and participated in traditional Ghanaian celebratory dances. Most of the dances featured everyone arranged in a rotating circle with complicated foot movements.
After the dances, we played with some of the children in the village. The children’s favorite game was to quickly roll bicycle tires with sticks for as long as possible. Although we tried to play with them, we were not nearly as talented and could not roll the tires for as long as the children could.
A young boy plays a popular game within the village of Bmognorie in Mole. From our observations, this particular child is the reining champion of bicycle tire rolling.
by Kaila Helm, Biological Basis of Behavior ’20; and Hope McMahon, Chemical and Biomolecular Engineering ’18
A sheep spotted relaxing atop a speeding van as we travel from Kumasi in the south to Mole National Park in the north.
David Issadore, a faculty member in the Department of Bioengineering at the University of Pennsylvania teaches an engineering course ENGR566 – Appropriate Point of Care Diagnostics. As part of this course, he and Miriam Wattenberger from CBE, have taken nine Penn students, most of them majoring in Bioengineering, to Kumasi, Ghana, to study the diagnosis of pediatric tuberculosis. While in Ghana, these students are blogging daily on their experiences.
Today we took a trip up north to Mole National Park. It was a little over a seven-hour drive from KCCR in Kumasi, but it went quickly as we drove past many communities. We were able to pick up food from vendors carrying it along the road. We picked up some of our favorites, like plantain chips, bananas, and groundnuts, and we even tried some new foods, like fried cheese.
A sleeping selfie taken as we embark on our 7-hour bus ride from Kumasi to Mole National Park. (Left to right: Kate Panzer, Jason Grosz, Katharine Cocherl, Ethan Zhao, Kathleen Givan, Dave Pontoriero)
Once we arrived in Mole, we were greeted by baboons, which like to stay around the motel. We had to be careful with any food that we brought because they could chase us for it. After a brief dip in the pool, we enjoyed a nice dinner overlooking the terrain below us.
The beautiful view of Mole National Park from the Mole Motel. (Left to right: Kate Panzer, Kathleen Givan, Katharine Cocherl, Kaila Helm, Danielle Tsougarakis, Hope McMahon)
We ended the night with another round of speed friending. By now, we had gotten to know each other to the point that leading questions weren’t necessary to carry conversations. After a few hours, we decided to retire for the night. When it became dark, we were amazed at how dark the sky was and how visible the stars were. We all went to bed, excited about the opportunity to go on a safari adventure tomorrow.
by Danielle Tsougarakis, Bioengineering ’20; and Kate Panzer, Bioengineering ’18
Our group at the expansive Adum Market in the heart of Kumasi. (Left to right: Katharine Cocherl, David Pontoriero, Ethan Zhao, Dr. David Issadore, Benjamin [Ghanaian KNUST student], Jason Grosz, Danielle Tsougarakis, Hope McMahon, Kathleen Givan, Kaila Helm, Genevieve, Dr. Miriam Wattenbarger, Kate Panzer, Nana)David Issadore, a faculty member in the Department of Bioengineering at the University of Pennsylvania teaches an engineering course ENGR566 – Appropriate Point of Care Diagnostics. As part of this course, he and Miriam Wattenberger from CBE, have taken nine Penn students, most of them majoring in Bioengineering, to Kumasi, Ghana, to study the diagnosis of pediatric tuberculosis. While in Ghana, these students are blogging daily on their experiences.
Today, we visited one of the largest markets we have ever seen, the Adum Market in the heart of Kumasi. There, you can find almost anything you can imagine, from fresh produce and meats to clothes, jewelry, and other trinkets. The market seems to go on forever, with many twists and turns that can easily make a tourist lost. One of our most enjoyable purchases was the Ghanaian cloth, with hundreds of vibrant colors and patterns to choose from. Later in the day, a seamstress took our measurements and clothing orders so that we could get handmade clothes with our chosen cloth.
Students explore the large selection of Ghanaian cloth. (Left to right: Hope McMahon, Kathleen Givan, Kate Panzer)
After a few hours of diligent bargaining at the market, we switched shopping scenes to the Kumasi City Center Mall, which was built a few months ago. Wide sections of the mall were partially open to the outdoors, welcoming us, as well as a nice breeze, into its various stores and hip social scene. We explored this more commercialized setting complete with a large supermarket, quite comparable to a Walmart. Many in the group invested in Ghana’s famed Golden Tree chocolate bars. The rich, creamy treats did not disappoint and served as the perfect snack after a full day of exploring.
Do not stop to think about the reasons for what you are doing, about why you are questioning. The important thing is not to stop questioning. Curiosity has its own reasons for existence. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery each day. Never lose a holy curiosity.
–Albert Einstein1
This haunting passage prompts a series of difficult questions. Should we ever worry about where our curiosity goes? Is it true that curiosity is an end in itself? Or, are its justifications so obvious to us as to go unquestioned? Have we lost our sense of mystery? What makes curiosity holy? Einstein himself did not study curiosity, nor could he revolutionize the field of curiosity studies, which is just coming into its own today. But he does capture the compulsion of curiosity and its tantalizing promise.
Kushal Sacheti, Founder and Director of the Center for Curiosity
The Center for Curiosity was established in New York in 2014 by Kushal Sacheti, a diamond merchant who was formerly an engineer. Its mission is to advance both the academic study of curiosity and the public practice of curiosity. A year after its founding, the first of its satellite centers was established at the University of Pennsylvania, in the School for Social Policy and Practice, under the leadership of Dean John Jackson, Jr. It is here that Mr. Sacheti’s dream of uniting engineering and curiosity came alive.
Given her work on the network neuroscience of human learning, Dr. Danielle Bassett, Associate Professor of Bioengineering, was one of the first faculty spotlighted in Penn’s Center for Curiosity seminar series. Her talk, “Flexible Brain Network Dynamics During Learning,” so perfectly represented the Center’s mission that she was quickly appointed to its advisory board. Shortly thereafter, Dr. Bassett invited the Center’s two postdoctoral fellows, Dr. Arjun Shankar and Dr. Perry Zurn, to lead curiosity workshops at the 2016 Penn Network Visualization program. This program provides young artists the opportunity to understand and creatively reimagine network science. Dr. Zurn’s seminar on structural models of curiosity, coupled with Dr. Shankar’s workshop on the affective elements of curiosity, inspired program fellows to explore curiosity not only in network science, but also in their own artistic praxis.
Dr. Arjun Shankar, Center for Curiosity, Postdoctoral FellowDr. Perry Zurn, Center for Curiosity, Postdoctoral FellowDr. Danielle Bassett (left) and Dr. Susan Engel (right) at the Curiosity Across the Disciplines Symposium, December 9, 2016
Behind Dr. Bassett’s Network Visualization program is a passion for thinking between the arts and sciences and a conviction that they are richer enterprises together. An even broader commitment to interdisciplinarity energizes Penn’s Center for Curiosity. Last December, Drs. Zurn and Shankar organized the Curiosity Across the Disciplines symposium. This day-long event explored the concept of curiosity across major academic disciplines (history, medicine, ecology, neuroscience, psychology, education, anthropology, comparative literature, ethnic studies, political philosophy, and film). As presenters (including Dr. Bassett) reflected on their fields’ contributions to curiosity studies, as well as the role of curiosity in their own scholarship, a deeper, shared conversation emerged about how curiosity can help us to collectively navigate the scientific, educational, and political challenges of our times.
The collaboration between Penn’s Center for Curiosity and the Department of Bioengineering has really only begun. This fall, Drs. Zurn and Bassett are co-organizing a symposium on The Network Neuroscience of Curiosity. Speakers will include Dr. Danielle Bassett, Dr. David Danks (Carnegie Mellon University), Dr. Jacqueline Gottlieb (Columbia University), and Dr. Celeste Kidd (University of Rochester). And, as a long-term project, they have started a conversation about reinvigorating the Bioengineering curriculum with an emphasis on student curiosity and creativity. Sharing Penn’s commitment to community outreach, moreover, the Center for Curiosity and Department of Bioengineering are also in conversation with Westtown School about building an art- and science-centered curiosity initiative there.
If indeed one cannot help but be curious about life and its mysterious design, that journey is perhaps best undertaken together—Einstein’s fabled solipsism notwithstanding. This exciting new partnership at Penn is yet another step in that direction.
1 Albert Einstein, Statement to William Miller, as quoted in LIFE magazine (2 May 1955); reprinted in Joseph S. Willis, Finding Faith in the Face of Doubt: A Guide for Contemporary Seekers (Quest Books, 2001), 58; and William Hermanns, Einstein and the Poet: In Search of the Cosmic Man (1983; Brandon Books, 2013), 138.
by Kathleen Givan, Bioengineering and Political Science ’20; and Katharine Cocherl, Bioengineering ’20
Students taking a tour of the Komfo Anokye Teaching Hospital (KATH) ICU. (Left to right: Katharine Cocherl, David Pontoriero, Kaila Helm, Hope McMahon, Benjamin [Ghanaian KNUST student])David Issadore, a faculty member in the Department of Bioengineering at the University of Pennsylvania teaches an engineering course ENGR566 – Appropriate Point of Care Diagnostics. As part of this course, he and Miriam Wattenberger from CBE, have taken nine Penn students, most of them majoring in Bioengineering, to Kumasi, Ghana, to study the diagnosis of pediatric tuberculosis. While in Ghana, these students are blogging daily on their experiences.
The vision statement, mission statement, and core values of Komfo Anokye Teaching Hospital (KATH) (click to enlarge).
We started our day by returning to KATH, although the clinical visits focused on HIV. We were lucky enough to see two patients, both heartbreaking and encouraging in their own ways. We were then shown around the sprawling complex that is KATH. The wards range from pediatrics and psychiatry to an elevated ward exclusive to those who can afford the price. We even got to see the oncology ward and speak to the head of the department. Interestingly, cancers such as skin and lung, which are prevalent in the U.S., are relatively rare in Ghana. However, cancers such as breast and cervical cancer account for 50% of the cases that they see. We finished our visit with a trip to the emergency room, which was somewhat oxymoronic, considering the grim conditions within the pastel walls.
We then had hoped to once again teach our students at the rural high school where we volunteer. Unfortunately, it looked too much like it was going to rain, so we were forced to turn back, since the children who must walk long distances to and from school were released early. For dinner, we headed over to a restaurant with live music and dancing. It was a nice emotional relief from our enlightening but taxing first week. The tilapia got rave reviews, and we learned that Ghanaian pizza tastes startlingly like cinnamon buns. We ended the evening by breaking out our middle school dance skills and having the Ghanaians show us up. All and all, a great start to a jam-packed weekend!
Students enjoy a dinner of grilled tilapia and Alvaro (a popular soda in Ghana). (Left to right: Hope McMahon, Kathleen Givan, Benjamin [Ghanaian KNUST student], Priscilla [Ghanaian KNUST student], Danielle Tsougarakis, Katharine Cocherl, Kaila Helm)
by Danielle Tsougarakis, Bioengineering ’20; Jason Grosz, Bioengineering ’19; Ethan Zhao, Bioengineering ’19; and Kate Panzer, Bioengineering ’18
At KCCR laboratories, Penn student Danielle Tsouragarkis checks out one of 120 GeneXpert throughout Ghana, which test for the presence of MDR TB.
David Issadore, a faculty member in the Department of Bioengineering at the University of Pennsylvania teaches an engineering course ENGR566 – Appropriate Point of Care Diagnostics. As part of this course, he and Miriam Wattenberger from CBE, have taken nine Penn students, most of them majoring in Bioengineering, to Kumasi, Ghana, to study the diagnosis of pediatric tuberculosis. While in Ghana, these students are blogging daily on their experiences.
Today is a holiday, Africa Day! That being said, we were unable to go to any hospitals, clinics, or schools today. Instead, after breakfast we continued our morning with a tour of Kumasi Center for Collaborative Research in Tropical Medicine (KCCR). KCCR specializes in tuberculosis diagnosis among other diseases – they are partnered with 40 hospitals and clinics throughout the country. Hospitals will send sputum and blood samples to KCCR for further diagnostics. One of the scientists at the center explained the procedure for testing for multidrug resistant (MDR) tuberculosis. When patients are diagnosed with mycobacterium tuberculosis, they are given first line of defense drugs, which include rifampin, isoniazid, pyrazinamide, ethambutol, and streptomycin with the first two drugs being the most potent. When no improvement shows from theses antibiotics, the patient will provide a sample to be tested in the GeneXpert for resistance to rifampin and isoniazid. After the samples are decontaminated, the sample is run through the GeneXpert to test for resistance to rifampin as well as the amount of MTB present in the sample (low, intermediate, high). If the sample expresses rifampin resistance then it is MDR TB. In addition to our comprehensive information session, we were also able to go into various laboratories throughout the facilities and view much of the equipment used in TB diagnostics such as the GeneXpert, thermocyclers, and PCR machines. We also had the opportunity to view gram-negative strains of tuberculosis up close under a microscope.
Penn students take a tour of the KCCR laboratories.
Later, one of the Ghanaian students drove us around to see his house and the area where he grew up. Distance-wise, his home isn’t far, about 4-5 miles away. However, driving took more than half an hour, not because of traffic, but because there were so many holes on the road that it was necessary to drive slowly over them at less than walking speed. We first visited the market where his mother owned a store. There, a large group of kids gathered and stared at us. Unable to communicate with those who only spoke Twi, we took out our deck of cards and managed to set up a game. Everything seems to be given more freedom, as children and chickens alike are allowed to roam the market freely, trusted to return to their respective homes at the end of the day. We then visited his grandmother’s house. His grandmother was originally from Northern Ghana, and she only spoke Hawza, a language spoken primarily by the Nigerian Muslim community, and not Twi, in contrast with the majority of the population. Overall, it was a great experience to go off campus to see the environment in which everyday Ghanaians work and live.
Penn students (left to right) Kate Panzer, Kaila Helm, Katharine Cocherl, Jason Grosz, and Ethan Zhao visit a nearby neighborhood where one of the KNUST students grew up.
Ankle sprains are among the most common injuries suffered. Not only do 23,000 sprains occur annually, but nearly two-thirds of people with sprained ankles don’t finish their rehabilitation programs, and more than one-third will sprain the same ankle again. A senior design project team that addressed this topic was one of this year’s three winners: the SockRocker
The SockRocker
Among the problems with the currently available rehab technologies are issues of effectiveness, lack of personalization, and poor accessibility. The team — which consisted of Aras Fanuscu, Andrea Frank, David Hernandez, and Angel Xiao — sought to address these issues, coming up with the SockRocker (right). The device, which cost approximately $350 to produce, combines targeted muscle therapy, individualized physician input, and a universal design. The patient places his/her foot into the SockRocker and is then able to move the ankle 30° in either direction, thus strengthening the injured joint. In a pilot study, the design team found that the SockRocker rated 4.8 out of 5 for comfort. In addition, the device is fully portable and can run on 24-volt battery for one month.
Going forward, the team hopes that the SockRocker can be tested clinically to determine its long-term efficacy. According to Timothy Dillingham, MD, MS, chair of the Department of Physical Medicine and Rehabilitation in the Perelman School of Medicine, the device has potential to close “an unfortunate gap in our clinical rehabilitation and management” of patients with ankle sprains.
by Kaila Helm, Biological Basis of Behavior ’20; Kathleen Givan, Bioengineering and Political Science, ’20; Kathryn Cocherl, Bioengineering ’20; Hope McMahon, Chemical and Biomolecular Engineering ’18; and Dave Pontoriero, Biotechnology MS ’18
Students speak with a clinician about the X-ray machine used for chest X-rays as a preliminary technique for diagnosing tuberculosis among other respiratory infections.
David Issadore, a faculty member in the Department of Bioengineering at the University of Pennsylvania teaches an engineering course ENGR566 – Appropriate Point of Care Diagnostics. As part of this course, he and Miriam Wattenberger from CBE, have taken nine Penn students, most of them majoring in Bioengineering, to Kumasi, Ghana, to study the diagnosis of pediatric tuberculosis. While in Ghana, these students are blogging daily on their experiences.
Our day started early. We woke up for a 7:00 a.m. breakfast of our usual combination of rolls with jam, sausages, omelets, and a beverage. After breakfast, we headed for the bus, where Uncle Ebo (our bus driver) was waiting to take us to a rural hospital about an hour away. We soon arrived at the Agogo Presbyterian Hospital. We were amazed by the organization and structure. At our previous hospital visit, we only saw a TB clinic. Today, we got to see a hospital that served a very different community. After spending some time in an old Presbyterian church, an administrator greeted us to begin our tour. We entered the main atrium, a large waiting room filled with more than a hundred people. We even saw a sheet used to characterize patients’ symptoms — a comprehensive list of numerous traits and experiences. We then continued our tour by entering the various wings and sections affiliated with TB treatment. This provided a wonderful opportunity to see a different side of the hospital’s operations.
Penn students wait to enter the tuberculosis clinic of the Agogo Presbyterian Hospital. (Left to right: Katharine Cocherl, Danielle Tsougarakis, Kaila Helm, Hope McMahon)
Initially, we were allowed to peek into the diagnosing wing. The first room was small and was purposed for smear microscopy tests. It had a few light microscopes and many technicians. Adjacent to this room was the GeneXpert room. Tucked away in the back corner was a small box (the GeneXpert), maybe 18 inches high. We were surprised at how small and streamlined it was — finally seeing the machine we have talked about for a solid semester was an almost surreal experience. It seems that they value it highly and therefore keep it well maintained and protected. We learned more about how they use the GeneXpert and the limitations they face, such as a limited number of cartridges, problems with overuse, and slow maintenance.
We then went into the X-ray room. As per our past lectures, this is the preferred initial screening methodology, so it was exciting to see how well established their systems are. There were two X-ray machines that were donated and used by the entire facility. The nurse also showed us how they store all the scans and showed us a scan of a pneumonia patient’s lung. They hope to introduce digital X-rays in the future, which will be better for analyzing and diagnosing. She taught us what to look for on the scans, saying that pneumonia is differentiated from TB because it is localized at the bottom lobes of the lung, whereas TB is more widespread and present in the top lobes as well. The tour concluded with a trip to the isolation room for TB patients, but time was limited, so we didn’t spend much time there.
Once we took the bus back to KCCR, we attended a lecture by Dr. David Issadore, who spoke about his research to a packed room filled with Ghanaian clinicians and researchers. They were very interested in his work, especially in how microfluidic chips could be used as a diagnostic for TB. Interestingly, the room was filled with clinicians and research scientists, but engineers were poorly represented. Dr. Issadore definitely made us proud!
Students taking a tour of the Agogo Presbyterian Hospital complex. (Left to right: Hope McMahon, Salim)
After the presentation, our group scattered. Some of us took control and hand-washed our clothes. A few numb fingers made for a very nice reminder about the little things we take for granted back in the States. After we worked up an appetite, we introduced the American classic of peanut butter and banana sandwiches to the Ghanaian students and Nana. We received some mixed responses, and we won’t be getting many returning customers, but it was nice to have a little bit of role reversal. Considering how much we have learned about Ghanaian culture through their food, it was nice to help them see a little bit of what America has to offer.
