APOC Ghana 2018: Day 5

By Yasmina Al Ghadban, Bioengineering ’20; and Rebecca Zappala, Bioengineering ‘21

Ghana 2018
From left to right: KNUST second-year medical student Muti Agyekum, Penn students Sheldon Amoo-Mitchual, Amber Figueroa, Rebecca Zappala, and Ethan Zhao.

This morning, after a breakfast of eggs, sausage, and toast, we headed to the Maternal and Child Welfare Center (at the Komfo Anokye teaching hospital) to visit the malnutrition ward. We learned about two types of severe acute malnutrition: marasmus, which is characterized by severe wasting due to starvation and a lack of both protein and energy nutrients; and kwashiorkor, which is characterized by swelling of the belly, cheeks, and limbs due to a lack of protein in the diet. We also learned about the process of treatment starting from diagnosis by measuring the mid-upper arm circumference (MUAC), as well as the weight. After the specific case of malnutrition has been diagnosed, healthcare providers look for underlying conditions, such as infection, anemia, HIV, or malaria, by running lab tests. For treatment, depending on the severity of the case and the age of the child, they administer F75 or F100, which are different kinds of ready-to-use therapeutic agents. After learning about the third case that we will be working on, we went to the nutrition center where families are sent for outpatient care and follow-up. This is also the first point of contact between the family and the healthcare system; if the case is severe, the patient is referred to the malnutrition ward that we first visited. At first, we had questions about how the follow-up process works. We discovered that mothers are supposed to come back weekly to collect more food and check the weight and MUAC of their children to track their progress. In cases in which mothers do not come back for their follow-up, they are called and sometimes even visited at their homes by nurses.

Although we had visited this same ward yesterday, it is still so hard to look at the children there. The clinic seems to be doing everything they can; however, it is difficult to ignore that there is a clear lack of resources, funds, and accessibility. For example, the malnutrition center had to move from being a 2-room clinic to a 1-room clinic due to a lack of funds. This resulted in having the waiting area, the food distribution, and the assessment of the child in the same confined space, which then limits the number of patients they can care for at once.

Ghana 2018
Penn student Ethan Zhao teaches a grade 8 class at Kokoben Municipal Assembly School about the importance of a balanced diet and its components.

Later in the afternoon, after a drive through the market and a stop to get coconuts, we headed to Kokoben Municipal Assembly school (kindergarten through grade 9) for service. We were divided into pairs, which each taught a class about something the grade was currently working on or wanted to learn. The experiences ranged from singing with 5-year-olds and struggling to communicate in English, as most children only know Twi, to teaching about heart diseases and the circulatory system. There was a lot of shock at first since it was not easy to stand in front of 40 students and teach an unprepared lesson. Overall, the kids seemed very excited and fascinated by our presence. Although we were glad we were able to spend some time with them and share an (infinitely) small part of knowledge, we were shocked by their fascination and overwhelming joy to see us.

As on our fourth day in Ghana, we feel like we have learned so much — both about the healthcare system and the culture, and we look forward to continuing to learn and grow tomorrow.

APOC Ghana 2018: Day 4

By Xuanjie (Lucas) Gong, Biotechnology MS ’19; Shihan Dong, Biotechnology MS ’19; and Princess Aghayere, Health & Societies ‘19

Ghana 2018
MUAC tape

Today, we all went to the Maternal and Child Health Hospital in Rural Kumasi. The main purpose of the visit was to observe malnutrition cases in children and to interact with doctors and nurses who treat children suffering from malnutrition.

Ghana 2018
RUTF

While visiting the clinic, the nutrition group asked the questions that we prepared yesterday. It turns out that the situations here match up with our research. Doctors and nurses use WHO standards to determine the nutrition status of the kids. Also, they use MUAC tape to determine the severe acute malnutrition. Children who have MUAC less than 11.5 cm will be sorted into a severe acute malnutrition group.

As for solutions or treatments, they do know about and have RUTF (Ready-to-Use Therapeutic Food). We also learned that they have therapeutic milk, F-75 and F-100, to treat malnourished children in different phases. They have F-75 to use at the starting phase of treatment. If F-75 helps to stabilize the children, they move onto F-100, and they use diluted F-100 for children under 6 months.

We had 2 cases that we mainly focused on. The first case was of a 3-year-old girl who suffered from Kwashiorkor, Marasmus, and Marasmic Kwashiorkor. All 3 diseases are signs of severe acute malnutrition. She had been there for 3 weeks for treatment, and her condition was not improving. The doctors attributed her declining condition to poverty and the mother’s psychiatric problems. The patient’s mother has already lost two children to the same condition. The doctors describe the girl’s status as unstable because she often vomits and isn’t gaining weight. The second patient is a child exposed to HIV as a result of her mother being positive for the disease. Because she is only 3 months old, blood cannot be drawn, and testing cannot be done to ensure her HIV status.

Ghana 2018
F-75 therapeutic milk

In the evening, we went to a church to give a presentation to local women with little to no education. We started by asking them what they eat everyday, and luckily we received a lot of responses. From their responses, we could clearly see that their diet lacked components of vegetables and fruits. Then, we delivered a brief speech containing basic nutrition knowledge, mainly based on the six essential nutrients. We explained the function of these nutrients and some local sources to obtain them. Surprisingly, one of the female audience members said that this was her first time hearing about vitamins and minerals.

During the question and answer segment of our presentation, some women asked about the different types of sources for minerals and vitamins. In particular, one woman asked about the foods that she could eat to help with her hypertension. To our surprise, another women asked whether her intake of fruits was excessive. This question made us think about people’s awareness of obesity and other diseases related to overeating. At the end of the presentation, the audience was happy about what we presented today and looked forward to learning more on our next visit.

APOC Ghana 2018: Day 3

By Xuanjie (Lucas) Gong, Biotechnology MS ’19; Shihan Dong, Biotechnology MS ’19; and Princess Aghayere, Health & Societies ‘19

This morning, we had our official kickoff in the morning. It was a great meeting with Dr. Ellis, the Dean of School of Public Health. In the afternoon, professors from different schools delivered three lectures about the state of mental health, maternal and child nutrition, and health systems in Ghana.

Ghana 2018The mental health lecture, given by Dr. Emma Adjaottor, was impressive and surprising. We are so lucky that we met one of the psychiatric physicians among a hundred across the country. The doctor frankly introduced mental health development in Ghana. Though they have lagged behind, they have made a lot of progress, with the number of psychiatrists in Ghana  recently increasing from single digits to the double digits. Dr. Adjattor emphasized that the epidemiology of mental health in Ghana is nearly identical to the rest of the world, particularly in terms of incidence and prevalence, even though it is severely under-reported. The doctor explained that, although the epidemiology is the same, the terms used to describe these issues are often different, relying on more local ideas, such as spirits and witchcraft.

The maternal and child nutrition lecture, given by Dr. Samuel Newton, was even more astonishing. Kangaroo mother care (KMC), in which a prematurely born infant is given constant skin-to-skin contact with the mother, is undergoing study in Ghana, and it has shown promising outcomes. Even with limited studies, KMC has been found to greatly increase the likelihood of survival even when using “surrogates,” such as grandmothers and even fathers. The professor also introduced another study that found that the application of oxytocin during the third stage of labor in mothers at risk of postpartum hemorrhage (PPH) greatly decreased the likelihood of PPH.

Finally, Professor Ellis Owusu-Dabo gave an extensive lecture covering the health systems of Ghana, which are logically and hierarchically managed, with administrations at the national, local, district, sub-district, and community levels. We also learned about the insurance program in Ghana. For formally employed workers, national insurance participation is mandatory, as it is funded by a mandatory tax on their income, like in many socialist countries. However, insurance coverage is a more complicated matter in Ghana, in which a very large proportion of the population is not formally employed and instead earn its living through trading and cash-paying jobs. For these people, other than the free public health services provided by the government such as malaria, tuberculosis, and HIV care, they must pay out of pocket for many other services.

Tomorrow will be the very first clinic visit, where we can observe children suffering from severe acute malnutrition. So the three of us in the nutrition group, Princess, Shihan, and Xuanjie, gathered together after dinner to discuss what we would ask the doctors and nurses during the visit. We agreed that, at first, we should ask whether we can take pictures to record. As for nutrition, we will ask how healthcare workers there define malnutrition.

To our knowledge, malnutrition standards are normally based on BMI, which is a composition of weight, height, and age-related data. We want to know whether Ghanaian healthcare professions use the same standards here, as well as how the local standards differ from the established WHO standards. Furthermore, we will ask for access to their local data sets. In addition to the results of malnutrition, we also want to know what the major causes of malnutrition are. We assumed that the principal cause is poverty, and based on this assumption, we want to ask them whether there are any welfare systems or NGOs helping to resolve the problem. We hope to find out what the clinics’ initial steps are to resolve malnutrition. Our last question involves how macronutrients are measured.

Tomorrow evening, we will give an open presentation in a local church to female market workers. We first planned to deliver the presentation in a discussion form, but considering the language barrier and other factors, we decided to give a speech, but we will ask simple questions. We thought that the scope of our research was not appropriate for local life in Ghana because much of the research was done in the U.S.; thus, it was necessary to get the input of local people. By asking them questions about what they eat on a daily basis, we want to make our research as appropriate as possible. In relation to our presentation, we will briefly introduce what nutrition is and explain the 6 essential nutrients through definitions and explanation. For example, when introducing carbohydrates, we will refer to fufu or banku, which are local main dishes basically consisting of starch. Also, we came up with an educational idea for the future. If we have a projector, we could possibly show some dishes to let the audience choose which is more nutritious, to provide general idea of a nutritious diet.

APOC Ghana 2018: Day 2

By Sandy Tang, Bioengineering ’19; Eliza Culp, Fine Arts ’20; and Jessica Fan, Biotechnology MS ‘18

Ghana 2018
The mouthwatering jollof and fried tilapia we ordered at the swimming pool

This morning, we had a chance to sleep in a bit and recover from our busy travel day. We had a delicious breakfast that consisted of porridge with sugar cubes, sausage, hard boiled eggs, a locally specialized donut made of beans, watermelon, butter bread, and a variety of hot drinks: yum. After our breakfast, a group of us went on a walk around campus, and another group went to a church service at First Love Church.

The church service started with praise worship, followed by numerous student performances. There was a dance group, a drama group, a praise group, and a traditional Twi praise group, and the congregation members were bursting with energy. The pastor then gave her sermon and afterward greeted the congregation. We made a few friends who happened to be students at the university we are staying at: KNUST.

For the other group, we explored KNUST’s expansive campus. We started to wander, and only when we noticed excessive nature did we realize we were no longer on campus. Once back on track, we saw some lizards, baby goats, and plenty of flora and returned to the residential area of campus. We accidentally entered a boy’s dorm but caught a glimpse of what it would be like to be a student at KNUST. Inside the dorm, a pastor was giving a fiery sermon, and many students were hand washing laundry in the courtyard. After leaving the dorms a few of us bought some amazing meat pies, for only 1 Cedi (about a quarter)!

Around 1 p.m., we all got into our bathing suits to head to the pool! The ride was short, and we were excited to have some relief from the heat. We ordered some food before entering the water; there was a choice of jollof or fried rice with either fish or chicken. After ordering our food, we applied sunscreen and dove into the water. There were many other people in the pool already, so we made some friends with the swimmers our age, many of whom were instructors. Shortly after being in the water, Genevieve and Estabelle, two young girls, joined us in the pool, and we played with them and carried them around in the pool. It was such a great time.

We stayed until the pool closed at 6 p.m. and then dried off and took the bus back home. A few of us bought sweet treats from the little shop in our graduate student hostel, Tek Credit. Then, dinner was brought to us by Nana Yaa: a meal of yams, spinach fish stew, rice, fried fish, beef and water melon. We had a brief Twi lesson from Nana Yaa on basic greetings. Our night ended with a quick debrief from Dr. Wattenbarger about our upcoming week.

Excited for the days that lie ahead!

APOC Ghana 2018: Day 1

By Ethan Zhao, Bioengineering ’19 and Sheldon Amoo-Mitchual, Biological Basis of Behavior ‘20

Ghana 2018
The APOC team! From left to right, then bottom to top: Dr. Ocek Eke, Dr. Miriam Wattenbarger, Summer Kollie, Princess Aghayere, Eliza Culp, Bosede Ajiboye, Jessica Fan, Amber Figueroa, Xuanjie (Lucas) Gong, Sandy Tang, Ethan Zhao, Sheldon Amoo-Mitchual, Shihan Dong, Adam Yablonski, Yasmina Al Ghadban

Like last year, a group of Penn Engineering undergrads enrolled in ENGR566 – Appropriate Point of Care Diagnostics, a large number of them Bioengineering majors, have gone to Ghana to get some hand-on experience. They’re blogging their experiences daily.

Today we touched down in Accra bright and early at 8 a.m. We went through immigration and baggage claim without a hitch, and we met up with Nana Ya Awua-Boateng, a PhD student at the Kwame Nkrumah University of Science and Technology (KNUST), who helped us with arrangements as a translator. We loaded up the bus with luggage (both inside and out) and set off for the 5-hour bus ride to Kumasi. Along the way, we slept (a lot), given that we touched down at the equivalent of 4 a.m. EDT. We stopped in the middle for lunch and our first taste of Ghanaian jollof rice and grilled tilapia, which were incredible.

Afterward, we finished our journey to Kumasi and arrived at KNUST, where we unpacked our belongings in the hostel. We also met Salim, a medical student, and Nana Ya’s children, Nana and Genevieve. Soon after, we all took a quick trip down to Big Chinese Restaurant (its literal name) to taste Ghana’s version of Chinese food. We then went back to campus, where we finally went to bed after a long day’s journey.

Ghana 2018
Loading up the bus for our drive to Kumasi at the Accra airport! The bus was so full we had to strap luggage to the to the roof of the bus.

Classes End With Week of Events

The last week of April is when classes end at the University of Pennsylvania. It’s was an especially busy week for students in Penn’s Department of Bioengineering. In addition to university- and school-wide events, students enjoyed our department picnic and Senior Sendoff.

On Monday and Tuesday, junior Bioengineering students in BE 310 (Bioengineering Modeling, Analysis, & Design Laboratory II) participated in Demo Day, with presentations of groups’ solutions to a problem posed in the class to crate a spectrophotometer. The students’ creativity was on full display, with designs based on the McDonalds logo, Star Wars, and Hogwarts (see below).

classes end
Anthony Azagidi, Malika Shukurova, Mary Zhuo Ke, and Kathryn Khaw with their Hogwarts-inspired spectrophotometer

Wednesday was the Bioengineering Spring Picnic. Although the event had to be moved inside due to rain, students, faculty, and staff were able to enjoy a catered lunch. Thursday was Hey Day (April 26), the day on which Penn juniors across the university “officially” become seniors.

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(Kate Panzer, Karol Szymula, Nick Stiansen, and Jacqueline Valeri) for winning 2nd honorable mention at the SEAS Senior Design competition! — with Karol Szymula, Nick Vigilante, Nick Stiansen and Jacqueline Valeri.

Finally, on Friday, the school-wide Senior Design competition was held among the teams who won the previous week’s department-wide competition. One of our Bioengineering teams (see above) won second honorable mention. Congratulations to them and all of the winners!

Jina Ko Named Schmidt Scholar

Jina Ko
Jina Ko

Jina Ko, a PhD student in the Department of Bioengineering at the University of Pennsylvania, was among the 14 PhD candidates from the U.S., Canada, and Germany to be named to the inaugural class of Schmidt Science Fellows. The announcement was made on April 23 at the Apella Alexandria Center for Life Science in New York. Jina will receive a $100,000 to cover living expenses while working as a postdoctoral fellow under the auspices of the Rhodes Trust, which also administers the Rhodes Scholarships for student-athletes. The placement is preceded by a five-week orientation at the University of Oxford beginning this July.

An alumna of Rice University in Houston, Jina came to Penn in 2013 and has worked in the lab of Professor David Issadore, working on microfluidics and lab-on-a-chip technologies. “Jina is the ideal person for the Schmidt Fellowship,” Dr. Issadore said, “and I am very pleased that Eric and Wendy Schmidt agreed! Her work in my lab has brought together microfluidics with machine learning to develop diagnostics for diseases that do not have conventional biomarkers. By working with collaborators at Abramson Cancer Center and Presbyterian hospital, Jina demonstrated an ability to accurately diagnose pancreatic cancer at its earliest stages and prognose specific states of traumatic brain injury, both of which were not possible with previous technology. This fellowship will allow Jina to take a much deeper dive into machine learning and its application to next generation medical diagnostics during her post-doc, and I can’t wait to see what she develops.”

More Awards for Penn Bioengineering Students

Every year the Penn Bioengineering Department presents several awards to students. Last week, we featured our NSF scholarship winners and Rothberg Catalyzer first-prize winners. Here, we present more awards given to students for their service, originality, leadership, and scholarship.

More AwardsThe Albert Giandomenico Award, presented to four students who “reflect several traits that include teamwork, leadership, creativity, and knowledge applied to discovery-based learning in the laboratory,” was given to Jessica Rose, Michael Roth, Singh Gurjeet, Nicholas Vigilante. The Herman P. Schwan Award, named for a former faculty member in Bioengineering, was given to Anna Branch. In addition, Nicholas Stiansen received the Bioengineering Student Leadership Award and four students —Shira Rieke, Karol Szymula, Kate Panzer, and Michael Patterson — won the Penn Engineering Exceptional Service Award.

The Wolf-Hallac Award was established in October 2000 to be awarded to the best graduating female senior from Penn Engineering who is seen as a role model, has achieved a high GPA (top 10%) of class and who has demonstrated a commitment to school and or community. This year’s award was given to two stands: Jacqueline Valeri from Bioengineering and Anna Estep from Mechanical Engineering and Applied Mechanics. The Ben and Bertha Gomberg Kirsch Award, given by the Undergraduate Affairs Committee for achievement in applied science, went to BE’s Harvey Huang.

Last but certainly not least are our senior design and project award winners. This year’s Biomedical Applied Science Project Award was given to Bioengineering major Emily Bachner. The department’s Senior Design competition was held on April 16 and 18, and three teams were selected to continue to the school-wide competition this Friday. The three teams had the following members:

• Kate Panzer, Jackie Valeri, Nick Stiansen, and Karol Szymula
• Eric Helfgott, Margaret Schroeder, Manjari Ganti, and Kyle O’Neil
• Jessica Rose, Michael Roth, Gurjeet Singh, and Nick Vigilante

Congratulations to all of our winners!

Awards Season for Bioengineering Students

awards seasonIt’s awards season again, and Penn Bioengineering undergraduates and graduate students are among the honorees. Five students received fellowships from the National Science Foundation (NSF) Graduate Research Fellowship Program. Three of our current graduate students — Jason Andrechak, Brendan Murphy, and Wisberty Gordián Vélez — were awarded fellowships. In addition, two of our former undergrads — Elaida Dimwamwa and Ingrid Sheu Lan — won fellowships to attend graduate programs, respectively, at Georgia Tech and Stanford.

Among our Master’s students, Natalie A. Giovino was one of four recipients from the School of Engineering and Applies Science receiving Outstanding Academic Awards. BE undergraduate Jacqueline A. Valeri, who will go on to MIT for her PhD next year, received honorable mention. Finally, at the Rothberg Catalyzer at Penn over the last weekend in March, the first prize (runner-up to grand prize) award of $2,000 went to a team of Penn freshmen including Bioengineering major Jonathan Mairena.

“The successes of our remarkable students continue to be recognized in local and national competitions” says David Meaney, S.R. Pollack Professor and chair of Bioengineering, “and is more evidence of the special environment Penn has for bioengineering.”

Congratulations to all our winners!

Sam DeLuccia: Voices of Penn Engineering Master’s Alumni

Sam DeLuccia
Sam DeLuccia

Growing up and living in rural, upstate New York, there are a lot of things that stay off of your radar. I was always interested in science, technology, and medicine, but had very little exposure to the world of engineering until about four years ago.

As a competitive tennis player, my drive to be a college athlete steered much of my college search. Additionally, I knew that I wanted to go to a small school and to make an impact on the community, leading me to seek out liberal arts schools. I was recruited to Hobart and William Smith Colleges (HWS) in the Finger Lakes region of New York, and was excited to jump into the scientific community there. Though it was strong in traditional sciences, HWS did not have an engineering program. I majored in biology and was a pre-med student until I realized it was not for me. Trying my hand in molecular genetics research didn’t seem to click either, so I took a step away from science.

I loved being part of such an intimate community at HWS and wanted to give back to the school, so after I graduated I worked full-time for the admissions department and assistant-coached for men’s tennis for two years. I knew this was only temporary; I missed working in STEM!

After months of exploration, I discovered bioengineering — the perfect combination of biology, medicine, and technology. I was ready for the career switch and excited at the possibility. After applying to several schools with limited familiarity of what I was up against, University of Pennsylvania accepted me into the master’s program and I could not turn down the opportunity. Additionally, my brother was accepted into the Robotics Master’s program at the same time! As one can imagine, this was particularly exciting for my parents, as their years of love and support resulted in two of their children attending excellent programs together.

Continue reading at Penn Engineering’s Medium blog.