Tag: awards

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A Record 12 BE Students Receive 2019 NSF Graduate Research Fellowships

In a record year for the BE graduate program, twelve current and future students from the Department of Bioengineering were selected for the 2019 National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP). In addition, four more students were selected for honorable mention. This prestigious program recognizes and supports outstanding graduate students in NSF-supported fields. BE is thrilled to congratulate our excellent students on these well-deserved accolades! Continue reading below for a list of winning students and descriptions of their research.

Further information about the program can be found on the NSF website.

2019 NSF GRFP Recipients:

Tala Azar

Tala Azar is a PhD student in the Liu lab. During pregnancy and lactation, the maternal skeleton mobilizes to provide calcium for the developing fetus and breastfeeding, respectively. Tala’s current work seeks to isolate individual effects of pregnancy and lactation on the biology and structure of maternal bone in a rat and mouse model, which is important for understanding the mechanisms behind postmenopausal osteoporosis development.

 

Sarah Cai

Shuting (Sarah) Cai  is a current Bioengineering senior (BSE ’19).  She previously worked in Dr. Lloyd Miller’s Dermatology and Immunology Lab at Hopkins during the summer of her freshman year, and she has since been working in Dr. Andrew Tsourkas’s lab here at Penn on various projects involving development of nanoparticles for multimodal imaging and cancer theranostics.

 

Brandon Hayes

Brandon Hayes is a PhD student in the Discher lab. He is currently working on manipulating the macrophage immune checkpoint to exploit the mechanisms of phagocytosis for immunoengineering. The goal of this manipulation is to develop a new cell therapy and engineer new gene therapy and protein delivery approaches to target both immune cells and tumors.

 

Travis Kotzur

Travis Kotzur is a PhD student in the Winkelstein lab. His project revolves around better understanding the mechanisms of neuronally transduced pain from an injury within his lab’s models of the spine and the ligaments within.

 

 

Victoria Muir

Victoria Muir is a PhD student in the Burdick lab. She is studying injectable hyaluronic acid hydrogels for musculoskeletal tissue regeneration and repair.

 

 

 

Margaret Schroeder

Margaret Schroeder graduated with a BSE in 2018 and is currently completing her MSE, both in BE. She works in the Meaney lab. She studies astrocytic modulation of mesoscale neural populations in vitro, in the context of traumatic brain injury. She images the calcium activity of neurons and astrocytes to examine how astrocytes affect population response to single-cell mechanical injury.

 

Olivia Teter

Olivia Teter is a current Bioengineering senior (BSE ’19). She works in the Meaney lab which focuses on traumatic brain injury. Olivia’s work has been dedicated to understanding how injury propagates in neuronal networks. She uses a combination of in vitro experiments and computational analyzes to identify and evaluate possible mechanisms describing how the neuronal network changes after injury.

 

Tanniel Winner graduated with her BSE from Penn BE in the fall of 2015 and is now a PhD candidate in the Neuromechanics Lab at Georgia Tech and Emory University. She is working on machine learning models to classify and predict gait cycle states.

 

Honorable Mentions:

  • Margaret Billingsley – PhD student in the Mitchell lab
  • Dennis Andrew Huang – BSE 2018, now at the University of Texas at Austin
  • Brianna Marie Karpowicz – current BE senior (BSE ’19) and MSE student in Data Science
  • Hannah Zlotnick – PhD student in the Mauck lab

In addition to her honorable mention, Margaret Billingsley was also awarded the Tau Beta Pi Fellowship,  a selective program which provides a year of financial support for graduate study.

Finally, several honorees at other institutions will be joining our department in the fall of 2019. We congratulate them as well and look forward to welcoming them to Penn:

Congrats once again to everyone on another year of outstanding research!

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Building Literacy and Leadership Through Basketball

by Gwyneth K. Shaw

Bioengineering student Oladunni Alomaja, who goes by the nickname Ola, moved to the United States six years ago.

Princess Aghayere, Summer Kollie, and Oladunni Alomaja met for the first time before they even started college, at Penn’s Pre-Freshman Program. Drawn together by their common ties to West Africa, they became fast friends and, eventually, roommates. Kollie is originally from Liberia, and Aghayere and Alomaja were born in Nigeria.

Although all three moved to the United States as children or teenagers, each felt compelled to give back to Africa. As winners of one of the 2019 President’s Engagement Prizes (PEP), they will.

Their project, Rebound Liberia, aims to give young women a platform to develop their voices and, ultimately, to position them to create a new, more positive narrative about the country. It involves building a basketball court in Monrovia, the capital, and pairing it with literacy programs and a resource center.

The initial goal is to serve about 60 girls between the ages of 8 and 18, to complement what the young women are learning in school, and to build on those skills during the summer break. The PEP gives their project a $100,000 award, as well as a $50,000 living stiped for each of them.

All three women said the ability to begin their post-Penn lives giving back is hugely significant.

“We have always had that passion, that drive to want to work with youth in West Africa, to give back and just kind of help the youth in the way we have been helped along the way of our journey,” Kollie says.

“In Africa, West Africa especially, it’s very patriarchal,” says Alomaja, who goes by the nickname Ola. “We’re giving girls a voice. We’re empowering them, teaching them leadership skills. And we’re teaching them so many things that their society might have taken away from them or has not given them the opportunity to learn.

“For me, being involved in this project means I will be able to see that through and to have a close, interactive relationship with these girls for a long time, to help reach their own goals. I want to help them realize they’re more than what their society tells them they can be.”

Aghayere, a standout forward on Penn’s women’s basketball team, began playing basketball not long after she and her family moved to Virginia when she was 8. She’s driven by research showing the power of sports to teach leadership, and she can’t wait to expand the sport’s reach in Liberia.

“Basketball is definitely on the rise in Liberia. If we can build this program to a world-class program and really sort of help redefine Liberia in a new way, it will help. We’ve talked a lot about the negative narratives about Liberia,” Aghayere says. “We want to see this not only be self-sustainable but be something that people from all across West Africa come to and know Liberia for.”

The genesis of the project lies in Penn Engineering’s global and local-service program. Aghayere and Kollie had both been involved in summer projects in Africa and in 2018 won a grant from the Davis Projects for Peace Program.

Their project, Promoting Education and Cultivating Empowerment (PEACE) through Girls Basketball, renovated a basketball court in Monrovia and hosted a basketball clinic for girls twice a week. Each participant received a jersey, shoes, and a basketball, all donated by the Penn women’s basketball team.

Kollie and Aghayere also put together weekly workshops for the girls, discussing everything from sexual and reproductive health to goal-setting. They took the girls to Monrovia’s Coca-Cola plant and the nation’s Senate, two places where women are scarce.

After that success, the duo wanted to reach higher and began thinking about entering the annual contest for the PEP. Alomaja suggested adding in the literacy component to round out the program.

The trio approached Ocek Eke, the director of global and local-service learning programs in the School of Engineering and Applied Science. He knew all three women, since Alomaja is majoring in bioengineering and Kollie and Aghayere had worked on programs with him, and he agreed to be their faculty mentor for the project.

Read the full story at Penn Today.

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Strella Biotechnology’s Biosensors Minimize Food Waste, One Apple at a Time

By Erica K. Brockmeier

BE Senior Malika Shukurova (left) with her partner Katherine Sizov, Strella Biotechnology

Bringing home a bad apple or two from the grocery store might not seem like a huge deal to the average consumer. But for producers and sellers of fresh fruits and vegetables, the staggering 40% of food that goes bad before it even reaches a store means mounds of wasted food and nearly $1 trillion in lost profits.

Now, thanks to a 2019 President’s Innovation Prize (PIP) award, seniors Katherine Sizov of Alexandria, Virginia, and Malika Shukurova of Samarkand, Uzbekistan, plan to address the issue and optimize the produce supply chain. The prize will help them grow their novel biosensing technology startup company Strella Biotechnology.

Sizov, who is majoring in molecular biology, likes to ask everyone the same question when talking about Strella: “How old do you think an apple in a grocery store is?” As it turns out, an apple from a store may have been in storage anywhere from a couple months to up to more than a year. “That’s one fact that you don’t really consider when you go into a store because you’re so used to seeing fresh fruit,” she says.

The idea for Strella came to life when Sizov, who was previously doing undergraduate research on neurodegenerative disorders, found herself reading papers outside of her main area of study and chatting with Shukurova about what she learned about food waste. The two friends had met during freshmen year through the Penn Russian Club.

That 40% of all fresh produce going to waste is what motivated Sizov. “I thought it was the most ridiculous number in the world,” she says. “This clearly is a problem that could be solved, and, since ag is a bio space, I thought we could use the technical knowledge that we have to solve the problem.”

Shukurova, a bioengineering major, quickly became interested in seeking a solution with Sizov. “At that time I was becoming increasingly interested in the technical aspects [of the problem], and more focused towards building a solution by sensing,” she says. Their complementary areas of technical expertise, and two years of friendship, led to a collaboration.

They soon found a potential approach: Ripening fruits release ethylene gas, and the amount of the gas correlates with a fruit’s ripeness. The challenge, however, is that man-made compounds do not bind ethylene with much specificity, so it’s a difficult gas to measure.

Strella’s solution? “Hack the fruit,” says Sizov, explaining that fruits can already measure ethylene themselves. Placing a ripe banana next to an unripe banana, for example, causes the unripe fruit to ripen more quickly. “Why reinvent the wheel? Let’s use what a fruit uses to sense ethylene,” she says.

After Sizov “hacked” the fruit and had a potential biosensor in hand, Shukurova’s experience and technical knowledge in bioengineering gave her knowledge on both the electronic and biological aspects of the problem. Their patent-pending sensor is now a “leading ripeness indicator” that Strella can monitor on a constant basis.

But bringing their biosensor to market means overcoming technical and biological challenges, including biosensor stability and powering the electrical components that collect data. Sizov and Shukurova put together a team of people with complementary knowledge, including Zuyang Liu, an electrical engineering master’s student; Reggie Lamaute, an undergraduate studying chemistry and nanotechnology; and Jay Jordan, who has previous experience in sales and market development in agriculture.

Strella biotechnology came together thanks to a number of programs and resources at Penn, including the Wharton VIP-Xcelerate, the Wharton VIP Fellows program, Weiss Tech House, the Wharton Undergraduate Entrepreneurship Club, the Penn Engineering Miller Innovation Fellowship, and courses offered as part of the Engineering and Entrepreneurship Program. Sizov and Shukurova also say that Penn’s openness to innovation and the numerous resources for would-be entrepreneurs has expedited their success.

Mentorship was also crucial for the success of their startup, with both naming Sevile Mannickarottu and their PIP mentor, Jeffrey Babin, as instrumental resources. Babin, who first met Sizov when she took his engineering entrepreneurship lab and who later served as her Wharton accelerator program advisor, says that Sizov was able to take skills she gained in the classroom and directly apply them in business scenarios. “She’s fearless in terms of picking up the phone and talking to strangers, gauging the market place, and taking on the tough issues in starting a company,” he says.

Continue reading at Penn Today.

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BE’s Jason Burdick Receives the 2019 Acta Biomaterialia Silver Medal

by Sophie Burkholder

Dr. Burdick (second from the left) receives his award at the Annual Meeting of the U.S. Society for Biomaterials, April 2019

The Department of Bioengineering would like to congratulate our very own Jason A. Burdick, Ph. D., on being awarded the Acta Biomaterialia Silver Medal. Dr. Burdick is the Robert D. Bent Professor and a member of both the Laboratory for Research on the Structure of Matter (LRSM) and Center for Engineering Mechanobiology (CEMB) here at Penn.

The Acta Biomaterialia Silver Medal is an award from the monthly peer-reviewed scientific journal Acta Biomaterialia that recognizes leaders in academia, industry, and the public sector for mid-career leadership in and significant contribution to the field of biomaterials engineering. Dr. Burdick is the third recipient of the award so far, which includes a silver medal, an inscribed certificate, and reward of $5000. As the principal investigator of the Polymeric Biomaterials Laboratory in Penn’s Department of Bioengineering, Dr. Burdick leads research with a focus in polymer design, musculoskeletal tissue engineering, the control of stem cells with material cues, and the control of molecule delivery with polymers.

The Silver and Gold Medalists (Dr. Burdick and Dr. Antonios G. Mikos respectively) were presented with their own brand of wine in celebration of their achievement.

Specifically, Dr. Burdick’s innovation in the application of hydrogels to the musculoskeletal and cardiovascular systems brought him recognition for this award. His recent publications in Acta Biomaterialia include a study of bioactive factors for cartilage repair and regenesis in collaboration with fellow Penn Professor of Bioengineering Robert Mauck, Ph. D, and a study of adhesive biolinks that mimic the behavior of the extracellular matrix. The Acta Biomaterialia Silver Medal is only the most recent of several awards that Dr. Burdick has received, including both the George H. Heilmeier Faculty Award for Excellence in Research and the Clemson Award for Basic Research, and we can’t wait to see where his continued innovation in biomaterial engineering will take him next.

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Two BE Seniors Win the President’s Engagement and President’s Innovation Prizes

The Department of Bioengineering is proud to congratulate two of our graduating seniors on their 2019 President’s Engagement Prize and President’s Innovation Prize. Awarded annually, the Prizes empower students to design and undertake post-graduation projects that make a positive, lasting difference in the world. Each Prize-winning project will receive $1000,000, as well as $50,000 living stipend per team member.

Senior Oladunni Alomaja (right) with her partners Princess Aghayere and Summer Kollie, Rebound Liberia

BE senior Oladunni Alomaja (BSE 2019) and her partners Princess Aghayere and Summer Kollie won a President’s Engagement Prize for Rebound Liberia. Ola and her partners will use basketball as a tool to bridge the literacy gap between men and women and as a mechanism for youth to cope with the trauma and stress of daily life in post-conflict Liberia. Rebound Liberia will build an indoor basketball court in conjunction with a community resource center, and its annual three-month summer program will combine basketball clinics with daily reading and writing sessions and personal development workshops. The team is being mentored by Ocek Eke, director of global and local service-learning programs in the School of Engineering and Applied Science.

Senior Malika Shukurova (left) with her partner Katherine Sizov, Strella Biotechnology

BE senior Malika Shukurova (BSE 2019, also pursuing a MSE in BE) and her partner Katherine Sizov won a President’s Innovation Prize for Strella Biotechnology. Strella is developing a bio-sensor that can predict the maturity of virtually any fresh fruit. Strella’s sensors are installed in controlled atmosphere storage rooms, monitoring apples as they ripen. This enables packers and distributors to identify the ripest apples and fruit for their customers, thus minimizing spoilage and food waste and promoting sustainability. Strella’s current market is U.S apple packers and distributors, which represent a $4 billion produce industry. The startup is looking to expand to other markets, such as bananas and pears, in the future. Malika and Katherine are being mentored by Jeffrey Babin, Practice Professor and Associate Director of the Engineering Entrepreneurship Program. Katherine, a Biology major in the College of Arts and Sciences, developed the company as a sophomore in the George H. Stephenson Foundation Educational Laboratory, the primary teaching lab for the Department of Bioengineering.

Another winner of the President’s Innovation Prize, Wharton student Michael Wong for InstaHub, also has BE connections: One of the co-founders, Oladayo (Dayo) Adewole, graduated with a BSE in Bioengineering in 2015, went on to achieve his master’s in Robotics, and is currently back in BE pursuing his PhD. InstaHub’s mission is to eliminate energy waste through snap-on automation that enhances, rather than replaces, existing building infrastructure. Founded at Penn in 2016, InstaHub is focused on fighting climate change through energy conservation efforts with cleantech building automation technology. The initial development work for InstaHub was also done in the George H. Stephenson lab here in BE.

Congratulations once again to all the winners of this year’s President’s Engagement Prize and President’s Innovation Prize! Read more about the awards and all the winners at Penn Today and the Penn Engineering Medium Blog.

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Bioengineering Chair and Students Honored at the 2019 SEAS Awards

Each spring, the School of Engineering and Applied Science at the University of Pennsylvania hosts an awards recognition dinner to honor exceptional work in the school: The Faculty honor students for outstanding service and academics, while the students choose faculty members for their commitment to teaching and advising. This year, the Department of Bioengineering won big with honors for both our Department Chair and our undergraduates. Read about each of the award winners and see photos from the awards ceremony below. Congratulations to all the winners!

David F. Meaney, Ph.D.

Dr. David F. Meaney, Solomon R. Pollack Professor and Chair of Bioengineering, was awarded with the Ford Motor Company Award for Faculty Advising, which recognizes “dedication to helping students realize their educational, career and personal goals.” Dr. Meaney is beloved by the students in BE for his engaging teaching style, his commitment to student wellness and advancement, as well as his weekly Penn Bioengineering spin classes, and so we are delighted to see him recognized in this way by the wider student body  Read more about the award here and Dr. Meaney here.

Eshwar Inapuri (BAS 2019), a graduating senior completing his Bachelor of Applied Science degree in BE with minors in Biophysics and Chemistry, was awarded the Ben and Bertha Gomberg Kirsch Prize. This competitive award is decided by the SEAS faculty from among the Engineering undergraduate body and distinguishes a member of the B.A.S. senior class in  who “in applying the flexibility of the program, has created a personal academic experience involving the most creative use of the resources of the University.”

The Hugo Otto Wolf Memorial Prize, awarded to one or more members of each department’s senior class, distinguishes students who meet with great approval of the professors at large through “thoroughness and originality” in their work. This year, BE chose to share the award between Ethan Zhao (BSE 2019) and Shelly Teng (BSE 2019).

The Herman P. Schwan Award is decided by the Bioengineering Department and honors a graduating senior who demonstrates the “highest standards of scholarship and academic achievement.” The 2019 recipient of the Schwan Award is Joseph Maggiore (BSE 2019).

Every year, four BE students are recognized with Exceptional Service Awards for their outstanding service to the University and their larger communities. Our winners this year are Dana Abulez (BSE 2019), Daphne Cheung (BSE 2019), Lamis Elsawah (BSE 2019), and Kayla Prezelski (BSE 2019). All four of these recipients are also currently in the Accelerated Master’s program in BE.

And finally, BE also awards a single lab group (four students) with the Albert Giandomenico Award which reflects their “teamwork, leadership, creativity, and knowledge applied to discovery-based learning in the laboratory.” This year’s group consists of Caroline Atkinson (BSE 2019), Shuting (Sarah) Cai (BSE 2019), Rebecca Kellner (BSE 2019), and Harrison Troche (BSE 2019).

A full list of SEAS award descriptions and recipients can be found here.

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Week in BioE: April 5, 2019

by Sophie Burkholder

Tulane Researchers Use Cancer Imaging Technique to Help Detect Preeclampsia

Preeclampsia is potentially life-threatening pregnancy disorder that typically occurs in about 200,000 expectant mothers every year. With symptoms of high blood pressure, swelling of the hands and feet, and protein presence in urine, preeclampsia is usually treatable if diagnosed early enough. However, current methods for diagnosis involve invasive procedures like cordocentesis, a procedure which takes a sample of fetal blood.

Researchers at Tulane School of Medicine led by assistant professor of bioengineering Carolyn Bayer, Ph.D., hope to improve diagnostics for preeclampsia with the use of spectral photoacoustic imaging. Using this technique, Bayer’s team noticed a nearly 12 percent decrease in placental oxygenation in rats with induced preeclampsia when compared to normal pregnant rats after only two days. If success in using this imaging technology continues at the clinical level, Bayer plans to find more applications of it in the detection and diagnosis of breast and ovarian cancers as well.

New CRISPR-powered device detects genetic mutations in minutes 

Two groups of researchers from the University of California, Berkeley and the Keck Graduate Institute of the Claremont Colleges recently collaborated to design what they call a “CRISPR-Chip” –  a combination of the CRISPR-Cas9 System with a graphene transistor to sequence DNA for the purpose of genetic mutation diagnosis. While companies like 23andMe made genetic testing and analysis more common and accessible for the general public in recent years, the CRISPR-Chip looks to streamline the technology even more.

This new chip eliminates the long and expensive amplification process involved in the typical polymerase chain reaction (PCR) used to read DNA sequences. In doing so, the CRISPR-Chip is much more of a point-of-care diagnostic, having the ability to quickly detect a given mutation or sequence when given a pure DNA sample. Led by Kiana Aran, Ph.D., the research team behind the CRISPR-Chip hopes that this new combination of nanoelectronics and modern biology will allow for a new world of possibilities in personalized medicine.

New Method of Brain Stimulation Might Alleviate Symptoms of Depression

Depression is one of the most common mental health disorders in the United States, with nearly 3 million cases every year. For most patients suffering from depression, treatment involves prolonged psychotherapy, antidepressant medication, or even electroconvulsive therapy in extreme cases. Now, scientists at the University of North Carolina School of Medicine study the use of transcranial alternating current stimulation (tACS) to alleviate symptoms of depression.

Led by Flavio Frohlich, Ph.D., who has an adjunct appointment in biomedical engineering, this team of researchers based this new solution on information from each patient’s specific alpha oscillations, which are a kind of wave that can be detected by an electroencephalogram (EEG). Those who suffer from depression tend to have imbalanced alpha oscillations, so Frohlich and his team sought to use tACS to restore this balance in those patients. After seeing positive results from data collected two weeks after patients in a clinical trial receives the tACS treatment, Frohlich hopes that future applications will include treatment for even more mental health disorders and psychiatric illnesses.

University of Utah Researchers Receive Grant to Improve Hearing Devices for Deaf Patients

Engineers at the University of Utah are part of team that recently received a $9.7 million grant from the National Institute of Health (NIH) to design new implantable hearing devices for deaf patients, with the hope to improve beyond the sound quality of existing devices. The work will build upon a previous project at the University of Utah called the Utah Electrode Array, a brain-computer interface originally developed by Richard Normann, Ph.D., that can send and receive neural impulses to and from the brain. This new device will differ from a typical cochlear implant because the Utah Electrode Array assembly will be attached directly to the auditory nerve instead of the cochlea, providing the patient with a much higher resolution of sound.

People & Places

Vivek Shenoy, Eduardo D. Glandt President’s Distinguished Scholar in the Department of Materials Science and Engineering and Secondary Faculty in Bioengineering, has been named the recipient of the 2018–19 George H. Heilmeier Faculty Award for Excellence in Research for “for pioneering multi-scale models of nanomaterials and biological systems.”

The Heilmeier Award honors a Penn Engineering faculty member whose work is scientifically meritorious and has high technological impact and visibility. It is named for George H. Heilmeier, a Penn Engineering alumnus and advisor whose technological contributions include the development of liquid crystal displays and whose honors include the National Medal of Science and Kyoto Prize.

Read the rest of the story on Penn Engineering’s Medium blog.

We would also like to congratulate Jay Goldberg, Ph.D., from Marquette University on his election as a fellow to the National Academy of Inventors. Nominated largely for his six patents involving medical devices, Goldberg also brings this innovation to his courses. One in particular called Clinical Issues in Biomedical Engineering Design allows junior and senior undergraduates to observe the use of technology in clinical settings like the operating room, in an effort to get students thinking about how to improve the use of medical devices in these areas.

 

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BE’s Michael Mitchell Wins Controlled Release Society T. Nagai Award

Michael Mitchell, Ph.D.

Michael Mitchell, Skirkanich Assistant Professor of Innovation in the Department of Bioengineering, is the recipient of the Controlled Release Society (CRS) 2019 T. Nagai Postdoctoral Research Achievement Award, which comes with a $3,000 honorarium.

According to the CRS website, “The Controlled Release Society T. Nagai Postdoctoral Research Achievement Award has been established to recognize an individual postdoctoral candidate who has recently completed outstanding postdoctoral research in controlled release science and technology, and the postdoc’s advisor who played an integral role in those achievements.”

Mitchell and his postdoctoral advisor at MIT, Robert Langer, will receive the award at the 2019 CRS annual meeting this July in Valencia, Spain.

The sole recipient of this award, Mitchell was recognized for his work on engineering controlled release technologies for cancer gene therapy and immunotherapy. Mitchell focuses on improving the way drugs are delivered within the body by combining approaches from engineering, biology, machine learning, and data science to better target diseased cells. Mitchell’s work helps to lay the foundation for a new class of therapeutic strategies against hematologic cancers such as multiple myeloma and leukemia.

For this research, Mitchell also received the Burroughs Wellcome Fund Career Award at the Scientific Interface in 2016, the NIH Director’s New Innovator Award in 2018, and a Rising Star Award in Cellular and Molecular Bioengineering from the Biomedical Engineering Society in 2019. He joined the Penn faculty in January 2018 after completing an NIH NCI postdoctoral fellowship at the Koch Institute for Integrative Cancer Research at MIT.

Originally posted on the Penn Engineering Medium blog. Media contacts Evan Lerner. 

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Week in BioE (February 28, 2019)

by Sophie Burkholder

Louisiana Tech Sends First All-Female Team to RockOn

A team of faculty and students from Louisiana Tech University will participate in RockOn, a NASA-sponsored workshop on rocketry and engineering. Mechanical Engineering Lecturer Krystal Corbett, Ph.D., and Assistant Professor of bioengineering Mary Caldorera-Moore, Ph.D., will work together to lead the university’s first team of three all-female students at the event. At the program, they will have the chance to work on projects involving components of spacecraft systems, increasing students’ experience in hands-on activities and real-world engineering.

Refining Autism Treatments Using Big Data

Though treatments like therapy and medication exist for patients with autism, one of the biggest challenges that those caring for these patients face is in measuring their effects over time. Many of the markers of progress are qualitative, and based on a given professional’s opinion on a case-by-case basis. But now, a team of researchers from Rensselaer Polytechnic Institute (RPI) hopes to change that with the use of big data.

Juergen Hahn, Ph. D., and his lab recently published a paper in Frontiers in Cellular Neuroscience discussing their findings in connecting metabolic changes with behavioral improvements in autistic patients. Their analysis looks for multiple chemical and medical markers simultaneously in data from three distinct clinical trials involving metabolic treatment for patients. Being able to quantitatively describe the effects of current autism treatments would revolutionize clinical trials in the field, and lead to overall better patient care.

Penn Engineers Can Detect Ultra Rare Proteins in Blood Using a Cellphone Camera

One of the frontiers of medical diagnostics is the race for more sensitive blood tests. The ability to detect extremely rare proteins could make a life-saving difference for many conditions, such as the early detection of certain cancers or the diagnosis of traumatic brain injury, where the relevant biomarkers only appear in vanishingly small quantities. Commercial approaches to ultrasensitive protein detection are starting to become available, but they are based on expensive optics and fluid handlers, which make them relatively bulky and expensive and constrain their use to laboratory settings.

Knowing that having this sort of diagnostic system available as a point-of-care device would be critical for many conditions — especially traumatic brain injury — a team of engineers led by Assistant Professor in the Department of Bioengineering, David Issadore, Ph.D., at the University of Pennsylvania have developed a test that uses off-the-shelf components and can detect single proteins with results in a matter of minutes, compared to the traditional workflow, which can take days.

Read the full story on Penn Engineering’s Medium blog.

Treating Cerebral Palsy with Battery-Powered Exoskeletons

Cerebral palsy is one of the most common movement disorders in the United States. The disorder affects a patient’s control over even basic movements like walking, so treatments for cerebral palsy often involve the use of assistive devices in an effort to give patients better command over their muscles. Zach Lerner, Ph.D., is an Assistant Professor of Mechanical Engineering and faculty in Northern Arizona University’s Center for Bioengineering Innovation whose research looks to improve these kinds of assistive devices through the use of battery-powered exoskeletons.

Lerner and his lab recently received three grants, one each from the National Institute of Health (NIH), the National Science Foundation (NSF), and the Arabidopsis Biological Resource Center, to continue their research in developing these exoskeletons. Their goal is to create devices with powered assistance at joints like the ankle or knee to help improve patient gait patterns in rehabilitating the neuromuscular systems associated with walking. The team hopes that their work under these new grants will help further advance treatment for children with cerebral palsy, and improve overall patient care.

People & Places

David Aguilar, a 19-year-old bioengineering student at Universitat Internacional de Catalunya made headlines recently for a robotic prosthetic arm that he built for himself using Lego pieces. Due to a rare genetic condition, Aguilar was born without a right forearm, a disability that inspired him to play with the idea of creating his own prosthetic arm from age nine. His design includes a working elbow joint and grabber that functions like a hand. In the future, Aguilar hopes to continue improving his own prosthetic designs, and to help create similar versions of affordable devices for other patients who need them.

This week, we would like to congratulate two recipients of the National Science Foundation’s Career Awards, given to junior faculty that exemplify the role of teacher-scholars in their research. The first recipient we’d like to acknowledge is the University of Arkansas’ Kyle Quinn, Ph.D., who received the award for his work in developing new image analysis methods and models using the fluorescence of two metabolic cofactors. Dr. Quinn completed his Ph.D. here at Penn in Dr. Beth Winkelstein’s lab, and received the Solomon R. Pollack Award for Excellence in Graduate Bioengineering Dissertation Research for his work.

The second recipient of the award we wish to congratulate is Reuben Kraft, Ph.D., who is an Assistant Professor in Mechanical and Biomedical Engineering at Penn State. Dr. Kraft’s research centers around developing computational models of the brain through linking neuroimaging and biomechanical assessments. Dr. Kraft also collaborates with Kacy Cullen, Ph.D., who is a secondary faculty member in Penn’s bioengineering department and a member of the BE Graduate Group faculty.

Finally, we’d like to congratulate Dawn Elliott, Ph.D., on being awarded the Orthopaedic Research Society’s Adele L. Boskey, PhD Award, awarded annually to a member of the Society with a commitment to both mentorship and innovative research. Dr. Elliott’s spent 12 years here at Penn as a member of the orthopaedic surgery and bioengineering faculty before joining the University of Delaware in 2011 to become the founding director of the bioengineering department there. Her research focuses primarily on the biomechanics of fibrous tissue in tendons and the spine.

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Bioengineering Graduate Group Symposium – January 2019

On January 8, 2019 the Department of Bioengineering at Penn held its annual Graduate Group Research Symposium to great success.

Thank you to everyone who attended and participated, our student volunteers, our faculty who participated as judges for the student talks and poster competition, and especially to our keynote speaker, Dr. Sujata Bhatia, Professor of Chemical and Biomolecular Engineering at the University of Delaware.

Congratulations to the award winners:

Student Talks:

  • First prize – Meagan Ita
  • Second prize – Nicolette Driscoll
  • Third prize – Minna Chen

Poster Presentations:

  • First prize – Mariia Alibekova
  • Second prize – Jonathan Galarraga, Sonia Kartha, and John Viola
  • Third prize – Andrei Georgescu