Yogesh Goyal, Ph.D., a postdoctoral researcher in Genetics and Bioengineering, has been selected as a 2021 STAT Wunderkind, which honors the “next generation of scientific superstars.” Goyal’s research is centered around developing novel mathematical and experimental frameworks to study how a rare subpopulation of cancer cells are able to survive drug therapy and develop resistance, resulting in relapse in patients. In particular, his work provides a view of different paths that single cancer cells take when becoming resistant, at unprecedented resolution and scale. This research aims to help devise novel therapeutic strategies to combat the challenge of drug resistance in cancer.
Goyal is a Jane Coffin Childs Postdoctoral Fellow in the systems biology lab of Arjun Raj, Professor in Bioengineering and Genetics at Penn. He will begin an appointment as Assistant Professor in the Department of Cell and Developmental Biology (CDB) in the Feinberg School of Medicine at Northwestern University in spring 2022.
“I am so excited for Yogesh beginning his faculty career,” Raj says. “He is a wonderful scientist with a sense of aesthetics. His work is simultaneously significant and elegant, a powerful combination.”
With a unique background in engineering, developmental biology, biophysical modeling, and single-cell biology, Yogesh develops quantitative approaches to problems in developmental biology and cancer drug resistance. As a postdoc, Yogesh developed theoretical and experimental lineage tracing approaches to study how non-genetic fluctuations may arise within genetically identical cancer cells and how these fluctuations affect the outcomes upon exposure to targeted therapy drugs. The Goyal Lab at Northwestern will “combine novel experimental, computational, and theoretical frameworks to monitor, perturb, model, and ultimately control single-cell variabilities and emergent fate choices in development and disease, including cancer and developmental disorders.”
“I am excited to start a new chapter in my academic career at Northwestern University,” Goyal says. “I am grateful for my time at Penn Bioengineering, and I thank my mentor Arjun Raj and the rest of the lab members for making this time intellectually and personally stimulating.”
Congratulations to Dr. Goyal from everyone at Penn Bioengineering!
The BWF CASI Career Awards provide $500,000 over five years to bridge advanced postdoctoral training and the first three years of faculty service; and to foster the early career development of researchers who have transitioned from physical/mathematical/computational sciences or engineering into the biological sciences, and who are dedicated to pursuing a career in academic research. Goyal is one of just eight recipients of the 2020-2025 CASI award.
Goyal’s research work is centered around developing novel mathematical and experimental frameworks to study how a rare subpopulation of cancer cells are able to survive drug therapy and develop resistance, resulting in relapse in patients. In particular, his work will provide a view of different paths that single cancer cells take when becoming resistant, at unprecedented resolution and scale. In turn, this will help devise novel therapeutic strategies to combat the challenge of drug resistance in cancer.
“I am very excited to be a part of the community of the Burroughs Wellcome Fund CASI award past and present recipients, which also includes my postdoctoral adviser Arjun Raj, who received this award in 2008,” Goyal says. “This CASI award will help provide me with the freedom to pursue high risk research directions as I transition to faculty. I feel fortunate to be surrounded by kind and supportive colleagues in the Bioengineering Department at Penn, an environment that has been critical for my interdisciplinary journey as a scientist.”
The University of Pennsylvania Department of Bioengineering is proud to announce that Yogesh Goyal, a postdoctoral fellow in the laboratory of Professor Arjun Raj, PhD, has received two pretigious awards. First, has received the Jane Coffin Childs (JCC) Memorial Fund Fellowship, which is a premier fellowship for biomedical studies. The JCC fellowship provides three years of funding at approximately $50,000 per year to top scholars having received the PhD in the previous 18 months. In addition, along with recently minted Bioengineering PhD Jina Ko, Yogesh has been named one of the 14 inaugural Schmidt Science Fellows, each of whom receives $100,000 to cover living expenses while working as a postdoctoral fellow under the auspices of the Rhodes Trust.
“I am thrilled to have the opportunity to work with such a talented scientist in the coming years on quantitative problems related to development and cancer,” Dr. Raj said. “These fellowships are a well-deserved recognition of Yogesh’s scientific vision and dedication.”
Yogesh, a native of Jammu and Kashmir, India, received his undergraduate in chemical engineering at the Indian Institute of Technology. He then came to Princeton University and studied for the PhD in the Department of Chemical and Biological Engineering and the Lewis-Sigler Institute for Integrative Genomics, under the advisement of Stanislav Shvartsman, PhD, and Trudi Schüpbach, PhD. He came to Penn Bioengineering after finishing his doctorate.
“I am very excited to be selected for two prestigious fellowships,” Yoghes says. “I am looking forward to working with Arjun on learning experimental and computational single-cell techniques to understand developmental and invasive systems.”