We are thrilled to announce the successful recruitment of three (!) new faculty members to the department. We conducted a national faculty search and could not decide on one — we wanted all three of our finalists! We are very happy that they chose Penn and think we can provide an amazing environment for their education and research programs.
Alex Hughes, Ph.D., will join us in the Spring 2018 semester. Dr. Hughes comes to us from the University of California, San Francisco (UCSF), where he is a postdoctoral fellow. Alex’s research regards determining what he calls the “design rules” underlying how cells assemble into tissues during development, both to better understand these tissues and to engineer methods to build them from scratch
Lukasz Bugaj, Ph.D., will arrive in the Spring 2018 semester. Dr. Bugaj is also coming here from UCSF following a postdoc, and his work is in the field of optogenetics — a scientific process whereby light is used to alter protein conformation, thereby giving one a tool to manipulate cells. In particular, Lukasz’s research has established the ability to induce proteins to cluster ‘on demand’ using light, and he wants to use these and other new technologies he invented to study cell signaling in stem cells and in cancer.
Mike Mitchell, Ph.D., will also join us in the Spring 2018 semester after finishing his postdoctoral fellowship at MIT in the Langer Lab. In his research, Dr. Mitchell seeks to engineer cells in the bone marrow and blood vessels as a way of gaining control over how and why cancer metastasizes. Mike’s work has already had impressive results in animal models of cancer. His lab will employ tools and concepts from cellular engineering, biomaterials science, and drug delivery to fundamentally understand and therapeutically target complex biological barriers in the body.
In the coming month, we’ll feature podcasts of interview with each of the new faculty members, as well as with Konrad Kording, so be sure to keep an eye out for those.
A Penn Bioengineering professor, Paul Ducheyne, Ph.D., is the editor-in-chief of the new second edition of Comprehensive Biomaterials II, released by Elsevier on June 1. The seven-volume collection, which Dr. Ducheyne edited along with faculty members from the University of California, Berkeley, Queensland University of Technology (Australia), University of Utah, and Johannes Gutenberg University Medical Center (Germany), collects articles written by experts in the field of biomaterials.
According to Elsevier, the articles “address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications.”
In the preface to the collection, Dr. Ducheyne details how his team and Elsevier worked together to assure the continued high impact of the text by issuing it in both a print version and online via Elsevier’s Science Direct platform. He writes further, “It was the objective of the editorial team to compose the publication with chapters that would provide strategic insights for those working in diverse biomaterials applications, research and development, regulatory management, and industry.”
The National Institutes of Health (NIH) has awarded a grant to Brian Chow, Ph.D., an assistant professor in the Department of Bioengineering, to study ultrafast genetically encoded voltage indicators (GEVIs). GEVIs are proteins that can detect changes in the electrical output of cells and report those changes by emitting different color light. His research seeks to create GEVIs that can report these changes much more rapidly – in fact, more than a million times more quickly than the velocity of the changes themselves – and apply these ultrafast GEVIs to the study of the brain.
The NIH-funded research will build on earlier research, employing de novo fluorescent proteins (dFPs) created in Dr. Chow’s lab. These dFPs, which are totally artificial and unrelated to natural proteins, report voltage changes in neurons by changing in brightness. Working with a team of investigators that includes faculty members from the Departments of Biochemistry & Biophysics and Neuroscience, Dr. Chow hopes to develop these ultrafast GEVIs.
“Monitoring thousands of neurons in parallel will shed new light on cognition, learning and memory, mood, and the physiological underpinnings of nervous system disorders,” he says.
New research by faculty in the University of Pennsylvania Department of Bioengineering is examining the interplay between cells and their environment and how they impact the cells’ ability to grow and spread, showing that stiffness is not the only factor researchers should consider when studying this process.
The relationship between cellular adhesion and spread is a key factor in cancer metastasis. Better understanding of this dynamic would improve diagnosis of the disease and provide a potential target in combating it; reducing the ability of cells to grip their environment could keep them contained.
The study, published in the Proceedings of the National Academy of Sciences, was led by Vivek Shenoy, professor in the Department of Materials Science and Engineering, co-director of Penn’s Center for Engineering Mechanobiology, and a secondary faculty member in the Department of Bioengineering, along with Xuan Cao and Ehsan Ban, members of his lab. They collaborated with Jason Burdick, professor in the Department of Bioengineering, Boston University’s Christopher Chen, the University of Michigan’s Brendon Baker and the University of Hong Kong’s Yuan Lin.
This collaboration reflects work of The Center for Engineering Mechanobiology, a National Science Foundation-funded Science and Technology Center that supports interdisciplinary research on the way cells exert and are influenced by the physical forces in their environment.
Previous work from Shenoy’s group has shown that the relationship between cancer cells and the extracellular matrix is dynamic, containing feedback mechanisms that can change the ECM’s properties, including overall stiffness. One earlier study investigated how cancer cells attempt to strike a balance in the density of the fibrous netting surrounding them. If there are too few fibers to grip, the cells can’t get enough traction to move. If there are too many, the holes in the net become too small for the cells to pass through.
Susan S. Margulies, Ph.D., currently professor of bioengineering at the University of Pennsylvania, has been named the Wallace H. Coulter Chair of the Department of Biomedical Engineering at Georgia Tech/Emory University and the Georgia Research Alliance Eminent Scholar in Injury Biomechanics. Her appointment begins August 1.
Dr. Margulies’s history at Penn goes back to 1982, she arrived at Penn to earn a master’s degree in the bioengineering department, followed by her Ph.D. in 1987. In 1993, she returned to Penn as an assistant professor, with promotion to associate in 1998 and full professor in 2004.
“At GT-Emory BME I will lead 72 faculty and 1,500 students, and look forward to creating impact in a new environment,” Dr. Margulies says. “As a Penn alum and emeritus faculty member, my ties here run deep. I look forward to keeping in touch.”
Dr. Margulies’s has deep roots at Penn indeed, and her accomplishments are broad and distinctive. They include:
Creating new faculty mentoring programs across the university, including the Penn Faculty Pathways program
When someone talks about using “your network” to find a job or answer a question, most people understand that to mean the interconnected web of your friends, family, and acquaintances. But we all have another key network that shapes our life in powerful ways: our brains.
In the brain, impulses whiz from one brain region to another, helping you formulate all of your thoughts and decisions. As science continues to unlock the complexities of the brain, a group of researchers has found evidence that brain networks and social networks actually influence and inform one another.
It found that people who show greater changes in connectivity in their mentalizing system during social exclusion compared to inclusion tend to have a less tightly knit social network — that is, their friends tend not to be friends with one another. By contrast, people with more close-knit social networks, in which many people in the network tend to know one another, showed less change in connectivity in their mentalizing regions.
The Department of Bioengineering at the University of Pennsylvania is proud to announce that Konrad Kording, PhD, currently professor of physical medicine and rehabilitation, physiology, and applied mathematics at Northwestern University, will join the BE faculty in the fall.
Dr. Kording, a neuroscientist with advanced degrees in experimental physics and computational neuroscience, is a native of Germany. After earning his PhD in 2001 at the Swiss Federal Institute of Technology in Zurich, he held fellowships at University College, London, and MIT before arriving at Northwestern in 2006.
Kording’s groundbreaking interdisciplinary research uses data science to understand brain function, improve personalized medicine, collaborate with clinicians to diagnose diseases based on mobile phone data, and even understand the careers of professors. Across many areas of biomedical research, his group analyzes large datasets to test new models and thus get closer to an understanding of complex problems in bioengineering, neuroscience, and beyond.
Dr. Kording’s appointment will be shared between the BE Department and the Department of Neuroscience in the Perelman School of Medicine.
In high school, Rebecca Kellner (right) always had a dual love of art and science. When she entered the University of Pennsylvania as a freshman, she thought that her interest in art would always be separate from her pursuit of science. “I’ve always loved art and science and I wondered how I would integrate my passions into one area of study,” Rebecca says. “Then I heard about the Network Visualization Program run by Dr. Danielle Bassett . In this program, the intersection of art and science is celebrated, and this intersection is a place where I feel right at home.”
The Penn Network Visualization Program, begun in 2014, had long been a dream of Dr. Bassett. She wanted a forum where young artists and research scientists could interact with each other. “Science and art are often perceived to be at odds with each other, two fundamentally different ways of understanding the world. As a scientist, I’ve learned that the visual impact of the information I present is crucially important. Networks are visually intuitive,” says Bassett, “and represent an opportunity to foster a common language between scientists and artists.”
In this six-week summer program, young artists spend time with scientists at Penn who are performing cutting-edge research in network science as applied to social systems, human biology, and physical materials, with the underlying goal of advancing bioengineering. Faculty from the Warren Center for Network and Data Science who have volunteered their time and creativity to the project include Eleni Katifori, Erol Akcay, and Randy Kamien of the School of Arts and Sciences; Robert Ghrist and Victor Preciado of the School of Engineering and Applied Sciences; Sandra Gonzalez-Bailon of the Annenberg School of Communications; and Francis Diebold of the Wharton School of Business. During the course of the internship, the artists produce works of art interpreting and capturing the intricacies of these networks in novel ways. Artistic supervision and project advice are provided by local artists affiliated with the program. The goal of the internship is to provide scientists with new conceptualizations of their research and to provide the intern with new knowledge in scientific art applications.
Rebecca was thrilled when she was accepted into the program. During her internship she worked with a variety of scientists. Her final artwork focused on the research of Dr. Ann Hermundstad (Janelia), the postdoctoral researcher in the Physics of Living Matter Group, University of Pennsylvania Department of Physics and Astronomy. Dr. Hermundstad’s research focuses on what and how the brain sees. Fascinated by these networks, Rebecca created a painting and a laser-etched acrylic book.
The program also invites six high school students who have exhibited creativity and academic achievement. Nicholas Hanchak (right) from Westtown School participated during the summer of 2016. “I love art, science and baseball and I am thinking about architecture as a possible career,” Nicholas says. “The Penn program challenged me to find new ways to combine these interests.” For his final project, Nicholas created a Plinko Game Board showing the difference between the networks in a healthy brain and in a brain damaged by stroke.
“Artists and scientists are kindred spirits because they both are interested in observing what is in front of them,” says Dr. Bassett. “The Network Visualization program offers an opportunity for scientists and artists to inform each other in very tangible ways.”
The program runs every other summer. During the fall, several of the artists’ pieces are showcased in Philadelphia-area middle and high schools, particularly in disadvantaged areas. These efforts are enabled by ongoing collaborations with the Netter Center for Community Partnerships and Penn’s Center for Curiosity, and they are partially funded by the National Science Foundation. Bassett hopes this outreach effort will encourage children to explore intersections between the arts and sciences, while instilling a growing appreciation of their networked world.
Daniel K. Bogen, MD, PhD, a professor in Penn’s Department of Bioengineering, is retiring. A Harvard alumnus (AB, 1972; PhD, 1977; MD, 1979). Dr. Bogen was the the first MD/PhD hired by the department in its history. Starting at Penn in 1982, Dr. Bogen spent his entire career on the faculty.
Early in his career, Dr. Bogen focused on cardiac tissue mechanics and understanding the functional changes that occur to heart tissue after ischemic insult. These publications were among the first to use finite element techniques to address the critical problem of how heart wall contraction changes after injury. Some of these papers are continually cited even today. Motivated to work on practical and applied clinical bioengineering-based problems, Dr. Bogen transformed his research to build items that patients would use. Rather than a timescale from discovery to application that can last decades for most academic researchers, Dr. Bogen’s new direction allowed him to put items in the hands of patients within months. In addition, Dr. Bogen’s led the PENNToys program, a nationally known program designing toys for children with disabilities.
The passion for impact also extended into the classroom. Reimagining the laboratory education in bioengineering, he used NSF-sponsored funding to create a discovery-based educational experience for undergraduates. This laboratory educational experience became an international model program, copied by many highly ranked bioengineering/biomedical engineering programs. This educational program was the cornerstone of the proposal funded by the Whitaker Foundation, leading to the construction of Skirkanich Hall, the current home of the Department of Bioengineering, in 2006. As a testament to his gifts as an education, Dr. Bogen’s teaching excellence was rewarded in 2005 with the Christian R. and Mary F. Lindback Award, which is the highest university teaching award bestowed by Penn.
Dr. Bogen will remain active in his retirement, and always enjoys hearing from alumni and students. Feel free to send him a congratulatory note — firstname.lastname@example.org.
Every year this honor recognizes a scientist who has made major contributions to developing innovative biomedical technologies with the potential to have a broad impact on the life sciences. Dr. Huh, who is Wilf Family Term Endowed Chair in the BE Department, received the medal at an RCSI Research Retreat on March 9 on the RCSI campus in Dublin, and he delivered the John J. Ryan Distinguished Lecture.
“As an engineer, I am honored to have been selected by a group of biologists and clinicians for this prestigious award that recognizes significant contributions to biomedical research,” Professor Huh said. “It is truly rewarding and encouraging to experience strong support and enthusiasm for our pursuit of innovative biomedical technologies.”