Grace Hopper Distinguished Lecture: “Biomanufacturing Vascularized Organoids and Functional Human Tissues” (Jennifer A. Lewis)

We hope you will join us for the 2021 Grace Hopper Distinguished Lecture by Dr. Jennifer Lewis, presented by the Department of Bioengineering. For event links, email

Date: Thursday, March 25, 2021
Time: 3:00-4:00 PM EDT

Jennifer A. Lewis

Speaker: Jennifer A. Lewis, Sc.D.
Wyss Professor for Biologically Inspired Engineering
The Wyss Institue
Paulson School of Engineering and Applied Sciences
Harvard University

Title: “Biomanufacturing Vascularized Organoids and Functional Human Tissue”

Following the lecture, join us for a panel discussion “Horizon 2030: Engineering Life & Life in (Bio)Engineering” featuring Dr. Lewis and Penn faculty and moderated by Bioengineering students. Further details here.

Lecture Abstract:
Recent protocols in developmental biology are unlocking the potential for stem cells to undergo differentiation and self-assembly to form “mini-organs”, known as organoids. To bridge the gap from organoid building blocks (OBBs) to therapeutic functional tissues, integrative approaches that combine bottom-up organoid assembly with top-down bioprinting are needed. While it is difficult, if not impossible, to imagine how either organoids or bioprinting alone would fully replicate the complex multiscale features required for organ-specific function – their combination may provide an enabling foundation for de novo tissue manufacturing. My talk will begin by describing our recent efforts to generate organoids in vitro with perfusable microvascular networks that support their viability and maturation. Next, I will describe the generation of 3D vascularized organ-specific tissues by assembling OBBs into a living matrix that supports the embedded printing of macro-vessels by a process known as sacrificial writing in functional tissue (SWIFT).  Though broadly applicable, I will highlight our recent work on kidney, cerebral, and cardiac tissue engineering.

Dr. Lewis Bio:

Jennifer A. Lewis is the Jianming Yu Professor of Arts and Sciences, the Wyss Professor for Biologically Inspired Engineering in the Paulson School of Engineering and Applied Sciences, and a core faculty member of the Wyss Institute at Harvard University. Her research focuses on 3D printing of functional, structural, and biological materials that emulate natural systems. Prior to joining Harvard, Lewis was a faculty member in the Materials Science and Engineering Department at the University of Illinois at Urbana-Champaign, where she served as the Director of the Materials Research Laboratory. Currently, she directs the Harvard Materials Research Science and Engineering Center (MRSEC) and serves the NSF Mathematical and Physical Sciences Advisory Committee.

Lewis has received numerous awards, including the Presidential Faculty Fellow Award, the American Chemical Society Langmuir Lecture Award, the Materials Research Society Medal Award, the American Ceramic Society Sosman and Roy Lecture Awards, and the Lush Science Prize. She is an elected member of the National Academy of Sciences, National Academy of Engineering, National Academy of Inventors, and the American Academy of Arts and Sciences. Her research has enjoyed broad coverage in the popular media. To date, she has co-founded two companies, Voxel8 Inc. and Electroninks, that are commercializing technology from her lab.

Information on the Grace Hopper Lecture:
In support of its educational mission of promoting the role of all engineers in society, the School of Engineering and Applied Science presents the Grace Hopper Lecture Series. This series is intended to serve the dual purpose of recognizing successful women in engineering and of inspiring students to achieve at the highest level.
Rear Admiral Grace Hopper was a mathematician, computer scientist, systems designer and the inventor of the compiler. Her outstanding contributions to computer science benefited academia, industry and the military. In 1928 she graduated from Vassar College with a B.A. in mathematics and physics and joined the Vassar faculty. While an instructor, she continued her studies in mathematics at Yale University where she earned an M.A. in 1930 and a Ph.D. in 1934. Grace Hopper is known worldwide for her work with the first large-scale digital computer, the Navy’s Mark I. In 1949 she joined Philadelphia’s Eckert-Mauchly, founded by the builders of ENIAC, which was building UNIVAC I. Her work on compilers and on making machines understand ordinary language instructions lead ultimately to the development of the business language, COBOL. Grace Hopper served on the faculty of the Moore School for 15 years, and in 1974 received an honorary degree from the University. In support of the accomplishments of women in engineering, each department within the School invites a prominent speaker for a one or two-day visit that incorporates a public lecture, various mini-talks and opportunities to interact with undergraduate and graduate students and faculty.

Classes End With Week of Events

The last week of April is when classes end at the University of Pennsylvania. It’s was an especially busy week for students in Penn’s Department of Bioengineering. In addition to university- and school-wide events, students enjoyed our department picnic and Senior Sendoff.

On Monday and Tuesday, junior Bioengineering students in BE 310 (Bioengineering Modeling, Analysis, & Design Laboratory II) participated in Demo Day, with presentations of groups’ solutions to a problem posed in the class to crate a spectrophotometer. The students’ creativity was on full display, with designs based on the McDonalds logo, Star Wars, and Hogwarts (see below).

classes end
Anthony Azagidi, Malika Shukurova, Mary Zhuo Ke, and Kathryn Khaw with their Hogwarts-inspired spectrophotometer

Wednesday was the Bioengineering Spring Picnic. Although the event had to be moved inside due to rain, students, faculty, and staff were able to enjoy a catered lunch. Thursday was Hey Day (April 26), the day on which Penn juniors across the university “officially” become seniors.

classes end
(Kate Panzer, Karol Szymula, Nick Stiansen, and Jacqueline Valeri) for winning 2nd honorable mention at the SEAS Senior Design competition! — with Karol Szymula, Nick Vigilante, Nick Stiansen and Jacqueline Valeri.

Finally, on Friday, the school-wide Senior Design competition was held among the teams who won the previous week’s department-wide competition. One of our Bioengineering teams (see above) won second honorable mention. Congratulations to them and all of the winners!

Broad Street Run Is a Day Out for BE Students

Four students from the Bioengineering Department at the University of Pennsylvania participated in this year’s Blue Cross Broad Street Run, which was held on Sunday, May 7, in Philadelphia.

broad street run
(left to right) Melissa Schweizer, Mike Patterson, Kyle O’Neil, Margaret Schroeder

The four students (right) ran the annual event, which begins at Broad Street and W. Fisher Avenue, in the Logan section of North Philadelphia and runs almost the entire length of Broad to the Navy Yard in South Philadelphia. Broad Street is one of Philadelphia’s main thoroughfares and runs 11 miles along the city’s north-south axis. This year was the 38th year that the Broad Street Run has taken place.

“The Broad Street Run is one of the greatest Philadelphia running traditions,” department chair David Meaney, PhD, said, “and it is remarkable that our students would take time from their finals for an ‘easy’ ten-mile run — remarkable but not surprising.”