Organ-on-a-Chip Earns Big CRI Grant for Huh Lab

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Dan Huh, Ph.D.

As we reported earlier, Dan Huh, Wilf Family Term Chair & Assistant Professor in the Department of Bioengineering, has been awarded a $1 million grant from the Cancer Research Institute (CRI), along with its first CRI Technology Impact Award.

Recently, the Penn Engineering Blog featured a story on Dr. Huh’s grant and the research it will support for the next three years. You can read the story at the SEAS blog.

Congratulations again to Dr. Huh!

Dan Huh Receives $1M CRI Grant to Study Cancer

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Dan Huh, Ph.D.

Dan Huh, Wilf Family Term Assistant Professor in the Penn Department of Bioengineering, has received the Cancer Research Institute (CRI) Technology Impact Award. Dr. Huh, whose research attempts to model cancer-immune cell interactions in microphysiological systems, will receive $1 million over the next three years for direct costs of his research.

“This award will provide us with an exciting opportunity to explore the potential of our organ-on-a-chip technology for the study of cancer immunotherapy, which is one of the most promising yet poorly understood clinical strategies for cancer treatment,” Dr. Huh said. “I am honored to receive this major award and excited with the prospect of contributing to this rapidly emerging area of medicine using innovative bioengineering technologies.”

Join us in congratulating Dr. Huh!

Allen Foundation Awards Major Grant to Study Concussions

Faculty members in the Department of Bioengineering at the University of Pennsylvania are among the recipients of a major $9.25 million grant from the Paul G. Allen Family Foundation to study the mechanism underlying concussion and to investigate possible interventions.

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David Meaney, PhD, Solomon R. Pollack Professor and Chair of the Bioengineering Department (above left), is one of two principal investigators, with Douglas H. Smith, MD,  professor of neurosurgery at Penn’s Perelman School of Medicine (above right). In addition, Danielle S. Bassett, PhD, Eduardo D. Glandt Faculty Fellow and Associate Professor (below left), Dongeun (Dan) Huh, PhD, Wilf Family Term Assistant Professor (below center), and David Issadore, PhD, assistant professor (below right), all of BE Department, are co-investigators. The Allen Foundation grant also involves investigators from Columbia University (Barclay Morrison, Ph.D.), Duke University (Cameron Bass, Ph.D.), and Children’s Hospital of Philadelphia (Akiva Cohen, Ph.D.).

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Selected from a large national pool of applicants, the Allen Foundation grant will bring together new technology platforms developed by Drs. Huh and Issadore to study how concussions occur at the microtissue scale and release markers of rewiring  during recovery. Network theory models from Dr. Bassett’s group will provide an entirely new view on how concussion recovery occurs at all scales in the brain. The overall impact of the project will be to move away from the widely held perspective that all concussions should be treated identically and towards a view that concussions can follow several recovery pathways, some of which must be monitored closely in the days to weeks following injury.

Dan Huh Receives Ryan Medal

Ryan Medical recipient Dan Huh
Professor Dan Huh

A professor in the Penn Department of Bioengineering, Dongeun (Dan) Huh, PhD, has been awarded the John J. Ryan Medal, which is given annually by the Royal College of Surgeons in Ireland (RCSI).

Every year this honor recognizes a scientist who has made major contributions to developing innovative biomedical technologies with the potential to have a broad impact on the life sciences. Dr. Huh, who is Wilf Family Term Endowed Chair in the BE Department, received the medal at an RCSI Research Retreat on March 9 on the RCSI campus in Dublin, and he delivered the John J. Ryan Distinguished Lecture.

“As an engineer, I am honored to have been selected by a group of biologists and clinicians for this prestigious award that recognizes significant contributions to biomedical research,” Professor Huh said. “It is truly rewarding and encouraging to experience strong support and enthusiasm for our pursuit of innovative biomedical technologies.”