Puneeth Guruprasad Wins 2023 Penn Prize for Excellence in Teaching by Graduate Students

Front, from left to right: Lucy Andersen, Vice Provost for Education Karen Detlefsen, Derek Yang, Ann Ho, and Arianna James. Back, from left to right: Ritesh Isuri, Adiwid (Boom) Devahastin Na Ayudhya, Oualid Merzouga, and Puneeth Guruprasad.

Ten winners of the 2023 Penn Prize for Excellence in Teaching by Graduate Students were announced at a ceremony held April 13 at the Graduate Student Center. The recipients, who represented five of Penn’s 12 schools, were recognized among a pool of 44 Ph.D. candidates and master’s students nominated primarily by undergraduates—a quality unique to and cherished about this Prize.

“It’s a particularly authentic expression of gratitude from undergraduates, and that’s really the pleasure [of presenting these awards],” says Vice Provost for Education Karen Detlefsen, who was present to announce the winners and award them with a certificate. (They also receive a monetary award.) “I’m so proud of our students: Our undergraduates, for taking the time to recognize what it is our graduate students contribute to the student body, and the graduate students who are contributing to the life of the University.

“Students are the lifeblood of the University and without them, we wouldn’t be here.”

The Prize began in the 1999-2000 academic year under former Penn President Judith Rodin. It was spearheaded by then-doctoral-candidate Eric Eisenstein and has been issued every year since. Nominations for the Prize often mention how graduate teaching assistants were able to take a complex subject and make it relatable or craft a course like philosophy or mathematics into an enjoyable—even highly anticipated—experience for students.

“Many nominations show how much students value a TA or a graduate instructor of record who shows that they care for their learning and for them as people, and who makes themself readily available to assist,” says Ian Petrie, director of graduate student programming for the Center for Teaching and Learning, who organizes the selection committee for the Prize. “Typically, however, committee members are also interested in seeing nominations that really point to how a graduate student instructor taught or gave feedback—not just how responsive they were to emails or how many office hours they had.”

He also emphasizes that many winners this year were not just teachers, but mentors—often helping undergraduates or new graduate students navigate not only the course but also Penn as an institution.

Puneeth Guruprasad

One of the winners, Puneeth Guruprasad, hails from Penn Bioengineering. Guruprasad is a fourth-year Ph.D. student in Bioengineering who conducts research in the lab of Marco Ruella, Assistant Professor of Medicine in the Division of Hematology/Oncology in the Perelman School of Medicine. Ruella is also a member of the Center for Cellular Immunotherapies (CCI) and the Penn Bioengineering Graduate Group.

Guruprasad studies mechanisms of resistance to chimeric antigen receptor (CAR) T cell therapy for cancer. He has served as a teaching assistant for five semesters: three for Intro to Biotransport Processes (BE 3500) taught by Alex Hughes, Assistant Professor in Bioengineering, and two for Cellular Engineering (BE 3060), taught by Daniel Hammer, Alfred G. and Meta A. Ennis Professor in Bioengineering and in Chemical and Biomolecular Engineering. Both courses are a part of the core curriculum for undergraduate bioengineering students. His doctoral thesis focuses on how a specific interaction between CAR T cells and tumor cells limits their function across a range of cancers.

“I make myself approachable outside the classroom, and I think that’s one aspect of being a TA: having responsibilities that extend beyond the classroom,” says Guruprasad. “Dozens of times, I’ve spoken to students over coffee, or over some lunch, about what direction they want to take in their life, what they want to do outside of the course, and give them my two cents of advice. I try to individualize.”

This post was adapted from an original story by Brandon Baker in Penn Today. Read the full story and list of 2023 winners here.

This Patterned Surface Solves Equations at the Speed of Light

by Devorah Fischler

A tailored silicon nanopattern coupled with a semi-transparent gold mirror can solve a complex mathematical equation using light. (Image credit: Ella Maru studio)

Researchers at the University of Pennsylvania, AMOLF, and the City University of New York (CUNY) have created a surface with a nanostructure capable of solving mathematical equations.

Powered by light and free of electronics, this discovery introduces exciting new prospects for the future of computing.

Nader Engheta, H. Nedwill Ramsey Professor of Electrical and Systems Engineering at the University of Pennsylvania School of Engineering and Applied Science, is a visionary figure in optics and in electromagnetic platforms. For the last two decades, he has created theory and designed experiments to make electromagnetic and optical devices that operate at the fastest rate in the universe.

Engheta is the founder of the influential field of “optical metatronics.” He creates materials that interact with photons to manipulate data at the speed of light. Engheta’s contribution to this study marks an important advance in his quest to use light-matter interactions to surpass the speed and energy limitations of digital electronics, bringing analog computing out of the past and into the future.

“I began the work on optical metatronics in 2005,” says Engheta, “wondering if it were possible to recreate the elements of a standard electronic circuit at nanoscale. At this tiny size, it would be possible to manipulate the circuit with light, rather than electricity. After achieving this, we became more ambitious, envisioning collections of these nanocircuits as processors. In 2014, we were designing materials that used these optical nanostructures to perform mathematical operations, and in 2019, we anted up to entire mathematical equations using microwaves. Now, my collaborators and I have created a surface that can solve equations using light waves, a significant step closer to our larger goals for computing materials.”

The study, recently published in Nature Nanotechnology, demonstrates the possibility of solving complex mathematical problems and a generic matrix inversion at speeds far beyond those of typical digital computing methods.

The solution converges in about 349 femtoseconds (less than one trillionth of a second), orders of magnitude faster than the clock speed of a conventional processor.

Read the full story in Penn Engineering Today.

Nader Engheta is the H. Nedwill Ramsey Professor in the Departments of Electrical and Systems Engineering and in Bioengineering in the School of Engineering and Applied Science and Professor in Physics and Astronomy in the School of Arts & Sciences at the University of Pennsylvania.

Penn Bioengineering Alumnus Michael Magaraci Featured with New Haven Recycling Startup

Recycling bin full of plastic water bottles.
Credit: sdominick/Getty Images.

Michael Magaraci, Research Scientist at Protein Evolution and alumnus of Penn Bioengineering, featured in CT Insider for the New Haven, CT startup’s quest to replace the global recycling system. The company, founded in 2021, is working on methods to eventually recycle polyester fabrics, rugs, and other materials that end up in landfills. Magaraci, who serves as director of platform engineering, earned a bachelor’s degree in Bioengineering and Economics in the Jerome Fisher Program in Management & Technology from Penn Engineering and the Wharton School of Business in 2013. He stayed with Penn Bioengineering for his doctoral research, completed in 2021. During his time at Penn, he worked as a Teaching Assistant and Laboratory Technician, advised Penn iGEM Teams, and served with Engineers Without Borders.

Read “Meet the New Haven startup that wants to digest your plastic” in CT Insider.

Penn Bioengineering Alumnus Joshua Doloff Seeks a Pain-free Treatment for Diabetes

Person taking a finger stick blood test.
Credit: Darryl Leja, NHGRI Flickr

Joshua C. Doloff, Assistant Professor of Biomedical Engineering and Materials Science & Engineering at Johns Hopkins University, featured in The Jewish News Syndicate for his work on “Hope,” a new technology which offers pain- and injection-free treatment to people with Type 1 or “juvenile” diabetes. Doloff is an alumnus of Penn Bioengineering, Class of 2004:

“Doloff received his bachelor’s degree from the University of Pennsylvania and his graduate degrees from Boston University. In addition to his post in Johns Hopkins’ Department of Biomedical Engineering, he is a member of the Translational Tissue Engineering Center at Johns Hopkins University School of Medicine. His lab is interested in systems biology with an emphasis on engineering improved therapies in the fields of cancer, autoimmunity, transplantation medicine, including Type 1 diabetes and ophthalmology.”

Read “Technion researchers offer ‘Hope’ for treating diabetes, minus the painful jabs” in the Jewish News Syndicate.

Carl H. June, MD, FAACR, Honored with 2023 AACR Award for Lifetime Achievement in Cancer Research

Carl June, MD

 The American Association for Cancer Research (AACR), the largest cancer research organization in the country and based in Philadelphia, will bestow its 2023 Award for Lifetime Achievement in Cancer Research to Carl June, Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine at Penn Medicine. June is also Director of the Center for Cellular Immunotherapies, Director of the Parker Institute for Cancer Immunotherapy, and member of the Penn Bioengineering Graduate Group. He is recognized for his groundbreaking work in developing the first gene-editing cell therapy for cancer and for his pioneering work with CAR T cell therapy.

Read the press release on the AACR website.

LeAnn Dourte Receives the Provost’s Award for Teaching Excellence by Non-Standing Faculty

by Olivia J. McMahon

LeAnn Dourte
LeAnn Dourte

LeAnn Dourte, Practice Associate Professor in Bioengineering, has been awarded a 2023 Provost’s Award for Teaching Excellence by Non-Standing Faculty.

“This award reflects LeAnn’s innovation and dedication in teaching our students in Bioengineering’s biomechanics, biomaterials and biomechatronics classes and labs,” says Ravi Radhakrishnan, Professor and Chair of Bioengineering. “She is a core member of our teaching faculty, spearheading the Department’s initiatives to improve experiential learning and classroom experiences through the SAIL model of education.”

The Structured, Active, In-Class Learning (or SAIL) model of education emphasizes teamwork and dynamic problem-solving. According to Penn’s Center for Teaching and Learning (CTL), SAIL “provides students with the opportunity to struggle through the application of course ideas and material, often the most difficult part of learning for students, with guidance from instructors as well as help from their peers.”

In addition to her pedagogical interests, Dourte serves on the Bioengineering Climate Committee and is also highly involved in student wellness programming, serving as the Department’s Wellness Ambassador for the School.

The Provost’s Awards for Teaching Excellence by Non-Standing Faculty were established in 1988.

Read “Two Penn Engineers Receive 2023 Provost’s Teaching Awards” in Penn Engineering Today.

Read more stories featuring LeAnn Dourte.

Sharon Kuo Receives Inaugural Madison ‘Maddie’ Magee Award for Undergraduate Excellence

Sharon Kuo
Sharon Kuo

Sharon Kuo, a graduating senior in Mechanical Engineering and Applied Mechanics (MEAM), is the inaugural recipient of the Madison “Maddie” Magee Award for Undergraduate Excellence.

Kuo, who is also minoring in Mathematics, comes to Penn from Taipei, Taiwan. Her interests within her major include mechanical design and product design, and she is passionate about space exploration and advancing human spaceflight.

This award will continue to be presented each year to a Penn Engineering senior who best exemplifies the energy, enthusiasm and excellence that was Maddie.

Read the full story in Penn Engineering Today.

The award for Undergraduate Excellence was established in honor of Madison “Maddie” N. Magee, who graduated with both a bachelor’s degree in Mechanical Engineering and Applied Mechanics (MEAM) and a master’s degree in Bioengineering (BE) in 2021. Maddie passed away while hiking the Pacific Crest Trail on May 28, 2022. Read more about this award here.

The Big Bang at 75

by Kristina García

A child stops by an image of the cosmic microwave background at Shanghai Astronomy Museum in Shanghai, China on July 18, 2021. (Image: FeatureChina via AP Images)
A girl stops by an image of the cosmic microwave background (CMB) at Shanghai Astrology Museum in Shanghai, China Sunday, Jul. 18, 2021. The planetarium, with a total floor space of 38,000 square meters and claimed to be the world’s largest, opens to visitors from July 18. (FeatureChina via AP Images)

There was a time before time when the universe was tiny, dense, and hot. In this world, time didn’t even exist. Space didn’t exist. That’s what current theories about the Big Bang posit, says Vijay Balasubramanian, the Cathy and Marc Lasry Professor of Physics. But what does this mean? What did the beginning of the universe look like? “I don’t know, maybe there was a timeless, spaceless soup,” Balasubramanian says. When we try to describe the beginning of everything, “our words fail us,” he says.

Yet, for thousands of years, humans have been trying to do just that. One attempt came 75 years ago from physicists George Gamow and Ralph Alpher. In a paper published on April 1, 1948, Alpher and Gamow imagined the universe starts in a hot, dense state that cools as it expands. After some time, they argued, there should have been a gas of neutrons, protons, electrons, and neutrinos reacting with each other and congealing into atomic nuclei as the universe aged and cooled. As the universe changed, so did the rates of decay and the ratios of protons to neutrons. Alpher and Gamow were able to mathematically calculate how this process might have occurred.

Now known as the alpha-beta-gamma theory, the paper predicted the surprisingly large fraction of helium and hydrogen in the universe. (By weight, hydrogen comprises 74% of nuclear matter, helium 24%, and heavier elements less than 1%.)

The findings of Gamow and Alpher hold up today, Balasubramanian says, part of an increasingly complex picture of matter, time and space. Penn Today spoke with Balasubramanian about the paper, the Big Bang, and the origin of the universe.

Read the full Q&A in Penn Today.

Balasubramanian is Cathy and Marc Lasry Professor in the Department of Physics and Astronomy in the Penn School of Arts and Sciences and a member of the Penn Bioengineering Graduate Group.

Novel Tools for the Treatment and Diagnosis of Epilepsy

by Nathi Magubane

A neurologist examines an encephalogram of a patient’s brain.
Throughout his career, Brian Litt has fabricated tools that support international collaboration, produced findings that have led to significant breakthroughs, and mentored the next generation of researchers tackling neurological disorders. (Image: iStock Photo/Alona Siniehina)

When Brian Litt of the Perelman School of Medicine and School of Engineering and Applied Science began treating patients as a neurologist, he found that the therapies and treatments for epilepsy were mostly reliant on traditional pharmacological interventions, which had limited success in changing the course of the disease.

People with epilepsy are often prescribed anti-seizure medications, and, while they are effective for many, about 30% of patients still continue to experience seizures. Litt sought new ways to offer patients better treatment options by investigating a class of devices that electronically stimulate cells in the brain to modulate activity known as neurostimulation devices.

Litt’s research on implantable neurostimulation devices has led to significant breakthroughs in the technology and has broadened scientists’ understanding of the brain. This work started not long after he came to Penn in 2002 with licensing algorithms to help drive a groundbreaking device by NeuroPace, the first closed-loop, responsive neurostimulator to treat epilepsy.

Building on this work, Litt noted in 2011 how the implantable neurostimulation devices being used at the time had rigid wires that didn’t conform to the brain’s surface, and he received support from CURE Epilepsy to accelerate the development of newer, flexible wires to monitor and stimulate the brain.

“CURE is one of the epilepsy community’s most influential funding organizations,” Litt says. “Their support for my lab has been incredibly helpful in enabling the cutting-edge research that we hope will change epilepsy care for our patients.”

Read the full story in Penn Today.

Brian Litt is a Professor in Bioengineering and Neurology.

Flavia Vitale is an Assistant Professor in Neurology with a secondary appointment in Bioengineering.

Jonathan Viventi is an Assistant Professor in Biomedical Engineering at Duke University.

Penn Bioengineering Student Angela Song Named Goldwater Scholar

by Amanda MottLouisa Shepard

Four University of Pennsylvania undergraduates have received 2023 Goldwater Scholarships, awarded to second- or third-year students planning research careers in mathematics, the natural sciences, or engineering.

They are among the 413 students named 2023 Goldwater Scholars from more than 5,000 students nominated by 427 academic institutions in the United States, according to the Barry Goldwater Scholarship & Excellence in Education Foundation. Each scholarship provides as much as $7,500 each year for as many as two years of undergraduate study.

Penn has produced 59 Goldwater Scholars since Congress established the scholarship in 1986 to honor U.S. Senator Barry Goldwater.

Angela Song
Angela Song (Class of 2024)

Angela Song, from Princeton Junction, New Jersey, is a third-year majoring in bioengineering in the School of Engineering and Applied Science. She is interested in engineering molecular therapeutics for disease. She works in Douglas C. Wallace’s lab in the Center for Mitochondrial and Epigenomic Medicine at the Children’s Hospital of Philadelphia, focusing on designing engineered proteins with mitochondrial applications. At Penn, Song is the vice president of design for UnEarthed, a student-published educational magazine for West Philadelphia elementary school children, and president of the Penn American Red Cross Club. After graduating, Song plans to continue pursuing research through a Ph.D. in bioengineering.

Read the full list of Penn 2023 Goldwater Scholars in Penn Today.

Read about previous Penn Bioengineering Goldwater Scholars here.