Innovation in Action: Penn Engineering’s 2024 Senior Design Project Competition

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BE’s award-winning team, Epilog, at the 2024 Senior Design Awards.

How do you make robotics kits affordable for children in low-income countries? Speed up the manufacturing of organs-on-a-chip? Lower the environmental impact of condiments in restaurants?

If you’re a senior at Penn Engineering, the answer is to team up with your peers in the Senior Design Project Competition, which every year draws interdisciplinary groups from across the School’s six majors to solve real-world problems. Championed by the late Walter Korn (EE’57, GEE’68), a past president of the Engineering Alumni Society (EAS), Senior Design also invites alumni back to campus to evaluate the seniors’ year-long capstone projects.

Since the program started nearly two decades ago, hundreds of alumni have shared centuries’ worth of their collective experience with soon-to-be-minted graduates in the form of constructive feedback. “Senior Design is really one of the best days at Penn Engineering,” says Bradley Richards (C’92, LPS’17), Director of Alumni Relations, who manages the program. “Faculty advisors work with students all year long to bring out the best in each group’s efforts, and the results speak for themselves.”

This year, three student teams from each of Penn Engineering’s six departments — Bioengineering (BE), Chemical and Biomolecular Engineering (CBE), Computer and Information Science (CIS), Electrical and Systems Engineering (ESE), Materials Science and Engineering (MSE), and Mechanical Engineering and Applied Mechanics (MEAM)  — presented their work to more than 60 alumni in person and online.

Judges’ Choice Award

The Judges’ Choice Award, which recognizes overall excellence, went to ESE’s VivoDisk, which developed a novel machine to manufacture organs-on-a-chip for Vivodyne, a startup launched by Dan Huh, Associate Professor in BE.

As one of the team members, Akash Chauhan (ENG’24), learned while interning for Vivodyne, assembling the stacks of organs-on-a-chip, which are collections of plastic plates containing cells that simulate organs for preclinical drug testing, is extremely finicky and time consuming.

By developing a machine that could automatically align the plates with high precision using computer vision and AI, the team reduced the disks’ manufacturing time and expense, leading Vivodyne to adopt the device for commercial use, accelerating the process of drug discovery. VivoDisk’s team members included Chauhan; Angela Rodriguez (ENG’24), Aliris Tang (ENG’24, W’24), Dagny Lott (ENG’24), Simone Kwee (ENG’24) and Vraj Satashia (ENG’24, GEN’25) and was advised by Sid Deliwala, Alfred Moore Senior Fellow and Director of Lab Programs in ESE, and Jan Van der Spiegel, Professor in ESE.

Technology and Innovation Award

One of the greatest challenges for children with epilepsy is status epilepticus, an abnormal type of long-lasting seizure that is hard to distinguish from typical seizures and that has a mortality rate of 30%. There is currently no way to perform a test for status epilepticus at home, meaning that children suspected of having the condition must be rushed to the hospital for an electroencephalogram.

Epilog, a team from BE, developed a novel, wearable headset that analyzes brainwaves to accurately determine whether or not a child suffering a seizure is actually suffering from status epilepticus. The team, composed of Rohan Chhaya (ENG’24, GEN’24), Carly Flynn (ENG’24), Elena Grajales (ENG’24), Priya Shah (ENG’24, GEN’25) and Doris Xu (ENG’24) and advised by Erin Berlew, Research Scientist in the Department of Orthopaedic Surgery and Lecturer in BE, carefully validated the device’s accuracy.

The judges recognized Epilog’s technological expertise, which ran the gamut from software to hardware, including a custom app to work with the device and carefully considered features like electrodes whose position can be adjusted to accommodate a child’s growth over time.

Read the full story in Penn Engineering Today.

Building Tiny Organs

by David Levin

Dan Huh, Ph.D. (Photo credit: Leslie Barbaro)

More than 34 million Americans suffer from pulmonary diseases like asthma, emphysema and chronic bronchitis. While medical treatments can keep these ailments in check, there are currently no cures. Part of the reason, notes Dan Huh, is that it’s incredibly hard to study how these diseases actually work. While researchers can grow cells taken from human lungs in a dish, they cannot expect them to act like they would in the body. In order to mimic the real deal, it’s necessary to recreate the complex, 3D environment of the lung — right down to its tiny air sacs and blood vessels — and to gently stretch and release the tissue to simulate breathing.

Huh, Associate Professor in Bioengineering, is the cofounder of Vivodyne, a Penn Engineering biotech spinoff that is creating tissues like these in the lab. Vivodyne uses a bioengineering technology that Huh has been developing for more than a decade. While a postdoctoral fellow at Harvard’s Wyss Institute, he played a central role in creating a novel device called an “organ on a chip,” which, as the name implies, assembles multiple cell types on a tiny piece of engineered plastic to create an approximation of an organ.

“While those chips represented a major innovation,” says Huh, “they still weren’t truly lifelike. They lacked many of the essential features of their counterparts in the human body, such as the network of blood vessels running between different kinds of tissue, which are essential for transporting oxygen, nutrients, waste products and various biochemical signals.”

Read the full article in the Fall 2023 issue of the Penn Engineering Magazine.

Two Penn Bioengineering Professors Receive PCI Innovation Awards

From left to right: Marc Singer, Kirsten Leute, D. Kacy Cullen, Dan Huh, Doug Smith, and Haig Aghajanian

Two Penn Bioengineering Professors have received awards in the 7th Annual Celebration of Innovation from the Penn Center for Innovation (PCI).

Dongeun (Dan) Huh, Associate Professor in the Department of Bioengineering, was named the 2022 Inventor of the Year. D. Kacy Cullen, Associate Professor of Neurosurgery with a secondary appointment in Bioengineering, accepted the Deal of the Year Award on behalf of his company Innervace along with Co-Scientific Founder Douglas H. Smith, Robert A. Groff Professor of Teaching and Research in Neurosurgery in the Perelman School of Medicine.

PCI is interdisciplinary center for technology commercialization and startups in the Penn community. Their 7th Annual Celebration, held on December 6, 2022 at the Singh Center for Nanotechnology, honored Penn researchers and inventors whose achievements were a particular highlight of the fiscal year.

Huh was honored in recognition of his “extraordinary innovations in bioengineering tools.” The Huh Biologically Inspired Engineering Systems Laboratory (BIOLines) Laboratory is a leader in tissue engineering and cell-based smart biomedical devices, particularly in the “lab-on-a-chip” field of devices which can approximate the functioning of organs. Their research has been featured by the National Science Foundation (NSF, video below) and Wired, and has received a competitive Chan Zuckerberg Initiative (CZI) grant. Most recently, their “implantation-on-a-chip” technology has been used to better understand early-stage pregnancy. Huh and former lab member Andrei Georgescu (Ph.D. in Bioengineering, 2021) founded the spinoff company Vivodyne to bring this organ-on-a-chip technology to the industry sector. Fast Company included Vivodyne in a list of “most innovative” companies.

Innervace, represented by Cullen and Smith, took home the Deal of the Year award in recognition of its “successful Series A funding.” Innervace is another Penn spinoff which develops “anatomically inspired living scaffolds for brain pathway reconstruction.” Innervace raised up to $40 million in Series A financing to “accelerate a new cell therapy modality for the treatment of neurological disorders.” The Cullen Lab at Penn Medicine combines neuroengineering, regenerative medicine, and the study of neurotrauma to improve understanding of neural injury and develop cutting-edge neural tissue engineering-based treatments to promote regeneration and restore function.

Read the full list of 2022 PCI Award winners here.

Read more stories featuring Dan Huh and D. Kacy Cullen.