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Penn Alumnus Peter Huwe Appointed Assistant Professor at Mercer University

Peter Huwe, Ph.D.

Peter Huwe, a University of Pennsylvania alumnus and graduate of the Radhakrishnan lab, was appointed Assistant Professor of Biomedical Sciences at the Mercer University School of Medicine beginning this summer 2020 semester.

Huwe earned dual B.S. degrees in Biology and Chemistry in 2009 from Mississippi College, where he was inducted into the Hall of Fame. At Mississippi College, Huwe had his first exposure to computational research in the laboratory of David Magers, Professor of Chemistry and Biochemistry. He went on to earn his Ph.D. in Biochemistry and Molecular Biophysics in 2014 in the laboratory of Ravi Radhakrishnan, Chair of the Bioengineering Department at Penn. As an NSF Graduate Research Fellow in Radhakrishnan’s lab, Huwe focused his research on using computational molecular modeling and simulations to elucidate the functional consequences of protein mutations associated with human diseases. Dr. Huwe then joined the structural bioinformatics laboratory Roland Dunbrack, Jr., Professor at the Fox Chase Cancer Center as a T32 post-doctoral trainee. During his post-doctoral training, Huwe held adjunct teaching appointments at Thomas Jefferson University and at the University of Pennsylvania. In 2017, Huwe became an Assistant Professor of Biology at Temple University, where he taught medical biochemistry, medical genetics, cancer biology, and several other subjects.

During each of his appointments, Huwe became increasingly more passionate about teaching, and he decided to dedicate his career to medical education. Huwe is very excited to be joining Mercer University School of Medicine as an Assistant Professor of Biomedical Sciences this summer. There, he will serve in a medical educator track, primarily teaching first and second year medical students.

“Without Ravi Radhakrishnan and Philip Rea, Professor of Biology in Penn’s School of Arts & Sciences, giving me my first teaching opportunities as a graduate guest lecturer at Penn, I may never have discovered how much I love teaching,” says Huwe. “And without the support and guidance of each of my P.I.’s [Dr.’s Magers, Radhakrishnan, and Dunbrack], I certainly would not be where I am, doing what I love.  I am incredibly thankful for all of the people who helped me in my journey to find my dream job.”

Congratulations and best of luck from everyone in Penn Bioengineering, Dr. Huwe!

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Video Series Explores Penn Bioengineering’s Unique Bio-MakerSpace

A new series of short videos on the BE Labs Youtube Channel highlights the unique and innovative approach to engineering education found in The George H. Stephenson Foundation Educational Laboratory & Bio-MakerSpace, the primary teaching lab for the Department of Bioengineering at Penn Engineering. This video series explores how “engineering is fundamentally interdisciplinary” and demonstrates the ways in which Penn students from Bioengineering and beyond have combined the fields of biology, chemistry, and electrical, mechanical, and materials engineering into one exciting and dynamic “MakerSpace.”

“Our Bio-MakerSpace” takes viewers on a tour inside BE’s one-of-a-kind educational laboratories.

Produced primarily on smart phones and with equipment borrowed from the Penn Libraries, and software provided by Computing and Educational Technology Services, the videos were made by rising Bioengineering junior Nicole Wojnowski (BAS ‘22). Nicole works on staff as a student employee of the BE Labs and as a student researcher in the Gottardi Lab at the Children’s Hospital of Philadelphia (CHOP), helmed by Assistant Professor of Pediatrics Riccardo Gottardi.

Sevile Mannickarottu, Director of the Educational Labs in Bioengineering, says that the philosophy of the Bio-MakerSpace “encourages a free flow of ideas, creativity, and entrepreneurship between Bioengineering students and students throughout Penn. We are the only open Bio-MakerSpace with biological, chemical, electrical, materials, and mechanical testing and fabrication facilities, all in one place, anywhere.”

Previous stories on the BE blog have gone into detail about how BE’s Bio-MakerSpace has become a hub for start-ups in recent years, how students can build their own makerspace for under $1500, and more. Major award-winning start-ups including Strella Biotechnology and InstaHub got their start in the BE Labs.

To learn more about the Bio-MakerSpace, check out the other videos below.

Katherine Sizov (Biology ‘19), founder of the 2019 President’s Innovation Prize (PIP) award-winning company Strella Biotechnology, discusses how the Bio-MakerSpace is a hub for interdisciplinary innovation.

Bioengineering doctoral student Dayo Adewole co-founded the company Instahub, which also took home a PIP award in 2019. Dayo also graduated from the BE undergraduate program in 2014. In this video, he discusses the helpfulness and expertise of the BE Labs staff.

Senior Associate Dean for Penn Engineering and Solomon R. Pollack Professor in Bioengineering David Meaney discusses how the Bio-MakerSpace is the only educational lab on campus to provide “all of the components that one would need to make the kinds of systems that bioengineers make.”

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What do ‘Bohemian Rhapsody,’ ‘Macbeth,’ and a list of Facebook Friends All Have in Common?

New research finds that works of literature, musical pieces, and social networks have a similar underlying structure that allows them to share large amounts of information efficiently.

Examples of statistical network analysis of characters in two of Shakespeare’s tragedies. Two characters are connected by a line, or edge, if they appear in the same scene. The size of the circles that represent these characters, called nodes, indicate how many other characters one is connected to. The network’s density relates to how complete the graph is, with 100% density meaning that it has all of the characters are connected. (Image: Martin Grandjean)

 

By Erica K. Brockmeier

To an English scholar or avid reader, the Shakespeare Canon represents some of the greatest literary works of the English language. To a network scientist, Shakespeare’s 37 plays and the 884,421 words they contain also represent a massively complex communication network. Network scientists, who employ math, physics, and computer science to study vast and interconnected systems, are tasked with using statistically rigorous approaches to understand how complex networks, like all of Shakespeare, convey information to the human brain.

New research published in Nature Physics uses tools from network science to explain how complex communication networks can efficiently convey large amounts of information to the human brain. Conducted by postdoc Christopher Lynn, graduate students Ari Kahn and Lia Papadopoulos, and professor Danielle S. Bassett, the study found that different types of networks, including those found in works of literature, musical pieces, and social connections, have a similar underlying structure that allows them to share information rapidly and efficiently.

Technically speaking, a network is simply a statistical and graphical representation of connections, known as edges, between different endpoints, called nodes. In pieces of literature, for example, a node can be a word, and an edge can connect words when they appear next to each other (“my” — “kingdom” — “for” — “a” — “horse”) or when they convey similar ideas or concepts (“yellow” — “orange” — “red”).

The advantage of using network science to study things like languages, says Lynn, is that once relationships are defined on a small scale, researchers can use those connections to make inferences about a network’s structure on a much larger scale. “Once you define the nodes and edges, you can zoom out and start to ask about what the structure of this whole object looks like and why it has that specific structure,” says Lynn.

Building on the group’s recent study that models how the brain processes complex information, the researchers developed a new analytical framework for determining how much information a network conveys and how efficient it is in conveying that information. “In order to calculate the efficiency of the communication, you need a model of how humans receive the information,” he says.

Continue reading at Penn Today.

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Bridging the Communication Divide for Deaf and Hard-of-hearing Communities

Clear-fronted face masks, better and more frequent interpreters, and amped up involvement from local organizations have made a big difference during the COVID-19 pandemic.

By Michele Berger

Since April 23, when bioengineering alum Kate Panzer (above) and her partners at the Deaf-Hearing Communication Centre started taking orders for masks with clear fronts, they’ve shipped about 450, with a backlog of requests for hundreds more. (Image: Courtesy Kate Panzer)

Because COVID-19 spreads via respiratory droplets that disperse through sneezes and coughs, shielding the mouth and nose is an important weapon against the virus. But it can also hinder conversations for people who rely on reading lips. “Communication barriers are already difficult sometimes, and this makes it more difficult,” says linguist , director of ’s .

It’s one of the trickiest aspects of this pandemic for those in the Deaf and hard-of-hearing communities, Fisher says. The challenge doesn’t stem just from misunderstandings due to wearing masks. It’s also about the dissemination of accurate and timely information, knowing who to rely on and how to assess what’s being said.

Trusted sources like the Swarthmore, Pennsylvania–based nonprofit Deaf-Hearing Communication Centre (DHCC), a Penn community partner, have filled that gap, frequently updating information on its social media channels and websites. Governors and mayors are more frequently using Certified Deaf Interpreters (CDI) during press briefings, and Penn alum Kate Panzer, who graduated in 2018, started a project with DHCC to sew masks with clear fronts to offer both lip-reading access and protection.

Innovative masks

Like much of the country, Panzer has stayed inside for the past several months. When the pandemic started to worsen, she temporarily left a research position in Michigan and returned to her childhood home in Media, Pennsylvania. And like many people, she wanted to give back.

At Penn, she’d taken several American Sign Language classes through the program Fisher runs, so when she read an article about a student in Kentucky making clear-fronted masks, it piqued her interest. She reached out to Fisher, who connected her with Kyle Rosenberg, DHCC’s community development and outreach coordinator.

As a volunteer, she shared her mask idea with Rosenberg. “Even in normal times, the Deaf community really struggles with clear communication,” says Rosenberg, who is himself deaf. “ASL is very visual. It relies on body language. Covering up the mouth with a mask makes communication 10 times harder.”

Rosenberg helped Panzer tweak a design and create a process to reach the community, and they took their first order on April 23. Since then, they’ve shipped about 450 masks, with a backlog of requests for hundreds more.

Though the response has been overwhelmingly positive, when constructive feedback comes in, they do take it to heart, Panzer says. For example, when mask-wearers told them that the elastic bands they’d been using rubbed uncomfortably against hearing aids, they switched to fabric ties that go around the back of the head. The masks are not medical grade, so they can’t be used in a hospital setting, but Panzer says her goal was to improve everyday interactions.

“When you can only see the eyes, it takes a lot out of expressive communication for Deaf people,” says Fisher, whose parents and one brother are deaf. “It’s really important that they be able to more fully convey facial expressions and mouth movements that influence meaning.” Masks with clear fronts help.

Continue reading at .

Kate Panzer earned her bachelor’s degree in 2018 from the Department of Bioengineering in the School of Engineering and Applied Science at the University of Pennsylvania. She is currently a disability health and family medicine research assistant at Michigan Medicine at the University of Michigan. 

NB: Kate has done prior work with ASL during her time at Penn Bioengineering. Kate’s 2018 Senior Design team created a two-way interface to help communication between deaf patients and hearing medical professionals called MEDISIGN. Fellow team members included fellow BE alumni Jackie Valeri, Nick Stiansen, and Karol Szymula. Watch their presentation on the Penn Engineering youtube channel.

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How Penn’s Medical Device Development Course Adapted to the COVID-19 Pandemic

Though BE 472 was able to quickly pivot to an entirely online curriculum, some in-person aspects of the course were unfortunately lost. Pictured: BE 472’s Spring 2019 MedTech panel discussion with industry leaders Katherine High, MD (President of Spark Therapeutics), Lucas Rodriguez, PhD (CEO of CerSci Therapeutics), and Penn BE alumnus Brianna Wronko (CEO of Group K Diagnostics) (credit: Lauren McLeod BE 2020).

by Sophie Burkholder

Given the closing of schools in response to the coronavirus pandemic, professors teaching lab-based courses were forced to make some changes. One such course, the Department of Bioengineering’s Medical Device Development (BE 472) taught by Matthew R. Maltese, Ph.D., usually requires students to develop a medical device and learn how to lead a startup venture for it. Over the semester, students design prototypes for unmet needs in the medical device community, and then go on to learn about business-related aspects of the project, like fundraising, regulations, teamwork, and leadership. Maltese often encourages junior engineering students to take the course, in the hopes that their projects might become launchpads for their senior design projects the following year.

But with the pandemic’s interruptions to education restricting access to the lab, or even to some of the schematics for their earlier designs, Maltese’s Spring 2020 students had to re-focus on the business side of their projects.

Fortunately, the shift to online learning came late enough in the semester that most students had already come up with solid project ideas. Maltese then shifted gears to the less hands-on parts of the course. “There’s lots of elements to this course that are not focused on putting hands on hardware,” he says. “They’re focused on distilling and disseminating information about your endeavor to people that are interested.”

While some of those more hands-off assignments originally had some face-to-face aspects, like the final pitch competition, they’re also easy to transition to an online format. Maltese had students record videos of their pitches, which he notes is perhaps more akin to what they might have to do for external pitch competitions. And even though students couldn’t make their physical prototypes, Maltese says that they were all able to make virtual prototypes through CAD or other modeling software.

In his opinion, this renewed focus on out-of-lab prototype models might be a good thing for real-world experience. Investors and stakeholders often want the full picture of a device or startup before they even have to start working with physical material, for the sake of cost efficiency.

Students had already been working on their projects for a couple of months before the pandemic started to affect classes, so most of them stuck to their original ideas instead of adapting them to meet the needs of the current medical crisis. “Next year, I think we’re going to focus the class on COVID-19 ideas though,” says Maltese.

In fact, Medical Device Development will likely be one of many Penn Bioengineering courses that adapts its curriculum to the challenges the pandemic presented. “As a medical device community, a pharmaceutical community, a healthcare community, we were not ready for this,” Maltese notes, “but history teaches us that some of our greatest innovations emerge from our greatest trials.”  He is excited for the future.

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A Message to the Penn Bioengineering Community

A message to the Penn Bioengineering community from BE leadership:

Dear BE Nation,

We wanted you to know that we in BE fully stand behind and reiterate the message from President Gutmann in full support of our Black students, postdocs, staff, colleagues, and friends.

As noted by President Gutmann, we all are feeling outrage, anger, grief, and myriad other emotions. We are at a loss to comprehend and to process the magnitude and implications of the brutality, oppression, and injustice that have come to light once again following the horrific event of George Floyd’s murder.

Several students and colleagues have reached out expressing their desires to contribute actively to effect a positive and progressive change. Our President Gutmann and Provost Pritchett have summarized some of the Penn initiatives towards our local communities in their message linked above. Numerous others are proactively contributing large and small. While we may not agree on many things, we can all agree that a lot remains to be done, and it will take time and sustained effort and commitment on our part. We are committed to the cause: to effect continual and progressive change for nurturing equality and cultural sensitivity as we build a diverse academic ecosystem, and this includes BE, Penn, and our surrounding community. It is our commitment to our Black friends and colleagues.

We take this opportunity to share this article sent by Denise Lay: Answering the Question, ‘What Can I Do?’ and this document compiled by BE Ph.D. student Lasya Sreepada created to share resources and opportunities for members of the University of Pennsylvania community to help their local communities.

Also, here are a  few resources to help cope:

Racial Justice and Equity (from Bucketlisters): A listing of resources, organizations and actions, including Philadelphia specific organizations.

Coping with Racial Trauma (recommended by Penn’s Counseling and Psychological Services [CAPS]): A mental, emotional, physical and spiritual toolkit for coping with racial trauma which provides a window into the personal cost of systemic racism, discrimination and inequality.

Mostly and immediately, we write this note to reiterate that we stand with and support our Black students, postdocs, staff, colleagues, and friends in this difficult period.

Sincerely yours,

Undergraduate Chair Andrew Tsourkas
Graduate Chair Yale Cohen
Department Chair Ravi Radhakrishnan

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2020 Awards Season for Bioengineering Students

Each spring, the School of Engineering and Applied Science at the University of Pennsylvania gives out awards of special recognition to honor exceptional work by undergraduate and graduate students. The Department of Bioengineering is proud to announce the following awards given to students in the Class of 2020.

Bioengineering Professor and Chair Ravi Radhakrishnan says, “Congratulations to all the winners! I am so incredibly proud of your accomplishments and I thank you for enriching the Bioengineering environment with your invaluable contributions.” Keep reading below for a list of 2020 award recipients.

UNDERGRADUATE AWARDS:

Katharine Cocherl (BAS 2020), who completed a Bachelor of Applied Science degree in Bioengineering along with a second major in Cinema and Media Studies, was awarded the Ben and Bertha Gomberg Kirsch Prize. This competitive award is decided by the SEAS faculty from among the Engineering undergraduate body and distinguishes a member of the B.A.S. senior class who “in applying the flexibility of the program, has created a personal academic experience involving the most creative use of the resources of the University.”

The Hugo Otto Wolf Memorial Prize, awarded to one or more members of each department’s senior class, distinguishes students who meet with great approval of the professors at large through “thoroughness and originality” in their work. This year, BE chose to share the award between Jacqueline Peng (BSE 2020) and Vera Lee (BSE 2020). In addition to their majors, Jacqueline also minored in Computer Science and is pursuing a Master’s degree in Data Science and Vera minored in the Engineering Entrepreneurship program and is pursuing a Master’s degree in Robotics.

The Herman P. Schwan Award is decided by the Bioengineering Department and honors a graduating senior who demonstrates the “highest standards of scholarship and academic achievement.” The 2020 recipient of the Schwan Award is Alexander Silva (BSE 2020) who is also graduating with a minor in Economics.

Every year, several BE students are recognized with Exceptional Service Awards for their outstanding service to the University and their larger communities. Our winners this year are Arielle Stern (BSE 2020 with a Math minor), Lauren McLeod (BSE 2020), and Evan Paregol (BSE 2020 with an Entrepreneurship minor). Arielle and Evan are also currently in the Accelerated Master’s program, in Data Science and Bioengineering, respectively.

The Student Leadership Award is given annually to a student in Bioengineering who has demonstrated, through a combination of academic performance, service, leadership, and personal qualities, that he or she will be a credit to the Department, the School, and the University. The 2020 recipient of this award is Katherine Simms (BSE 2020 with a minor in Chemistry).

BE also distinguishes a single lab group (four students) with the Albert Giandomenico Award which reflects their “teamwork, leadership, creativity, and knowledge applied to discovery-based learning in the laboratory.” This year’s group consists of Alisa Bhakta (2020 dual degree BSE in Bioengineering and BS in Economics from Wharton), Gabriel Desantis (BSE 2020 with a minor in Math), Lauren McLeod (BSE 2020), and Caroline Raquel (2020 dual degree BSE in Bioengineering and BS in Economics from Wharton).

Of this year’s Bioengineering Senior Design teams, three groups were chosen for special recognition:

  • RelieVR with Nicole Chiou (BSE 2020 with a minor in Computer Science), Gabe Desantis (BSE 2020 with a minor in Math), Ben Habermeyer BSE 2020 with a minor in Computer Science), and Vera Lee (BSE 2020 with an Engineering Entrepreneurship minor). RelieVR also won second place at the 2020 Johns Hopkins Healthcare Design Competition and took home the Berkman Prize this past fall semester.
  • Relila with Alisa Bhakta (dual degree BSE and BS 2020), Alexander Connor (BSE 2020), Lauren McLeod (BSE 2020), Alexa Murray (BSE 2020 in Systems Science and Engineering), and Caroline Raquel (dual degree BSE and BS 2020). Relila also won second place at the annual M&T Program Lab Integration Awards summit.
  • SchistoSpot with Alec Bayliff (dual degree BAS and BS in Economics 2020), Bram Bruno (BAS 2020), Justin Swirbul (BSE 2020 in Computer Science), and Vishal Tien (BSE 2020). SchistoSpot also won the Pioneer Award at the annual Rothberg Catalyzer Makerthon.

Research for these projects was conducted in the George H. Stephenson Foundation Education Laboratory & Bio-Maker Space. The abstracts and presentation videos for each of the 2020 Senior Design Competition winners can be viewed on the BE Labs website.

Additionally, two graduating BAS seniors were awarded prizes for Best Senior Thesis:

  • Katharine Cocherl (BAS 2020 in Bioengineering and Cinema and Media Studies) for her paper “Bioethical Assessments of Film Portrayals of the Opioid Epidemic and Its Relationship with Public Discourse and Policy from the 1990s to Present.” “Insightful, original, and wide-reaching, her study of films related to the opioid epidemic in the U.S. the past 25 years was one of the best senior theses I have advised at Penn the past 15 years, ” says Katharine’s advisor Lance Wahlert, Assistant Professor of Medical Ethics & Health Policy, Program Director of the Master of Bioethics
  • Gayatri Maria Schur (BAS 2020 with a minor in Music) for her paper titled “In Vivo Assessment of OXPHOS Capacity Using 3T CrCEST MRI in Adults and Children with Friedrich’s Ataxia.” Her advisor, Shana McCormack, Assistant Professor of Pediatrics in the Perelman School of Medicine, says that Gayatri’s “work has required that she communicate with collaborators across a variety of disciplines, and has also included interaction with the community of patients we study, and she has excelled here.”

GRADUATE AWARDS:

Master’s student Kayla Prezelski was awarded an Outstanding Teaching Award for students. Kayla served as a TA for the Department of Bioengineering’s two-semester Senior Design courses (BE 495/496).

The following Master’s students were awarded recognition for their Outstanding Research:

  • Linghan Mei – advisor Andrew Tsourkas, Ph.D., Professor of Bioengineering
  • Ayush Aditya Pal – advisor Lukasz Bugaj, Ph.D., Assistant Professor of Bioengineering
  • Robert Pierson – Independent Study advisor Brian Litt, M.D., Professor of Neurology, Neurosurgery, and Bioengineering, and Thesis advisors Insup Lee, Ph.D., Cecilia Fitler Moore of Computer and Information Science and Electrical and Systems Engineering, and James Weimer, Ph.D. Research Assistant Professor of Computer and Information Science
  • Tianjia Zhu – advisor Hao Huang, Ph.D., Research Associate Professor of Radiology in the Perelman School of Medicine

And finally, The Solomon R. Pollack Award for Excellence in Graduate Bioengineering is given annually to the most deserving Bioengineering graduate student who has successfully completed research that is original and recognized as being at the forefront of its field. This year, that award goes to Jonathan Beagan, Ph.D. who recently defended his thesis. Jon conducted his research in the 3D Epigenomics and Systems Neurobiology Lab overseen by Jennifer Phillips-Cremins, Ph.D., Associate Professor of Bioengineering. Research related to Jon’s award-winning doctoral thesis was recently published in the journal Nature Neuroscience. In addition to this prestigious award, Jon was also named a National Science Foundation Graduate Research Fellow during his time at Penn. Jon’s collaborations with Dr. Cremins have been covered several times on the BE blog. “Jon is an excellent researcher — simultaneously rigorous and creative,” says Dr. Cremins. “He has been a force in the lab — reading the literature voraciously, teaching other students, and executing/designing experiments meticulously. Beyond his natural talent, it is Jon’s personal qualities that make him stand out. He is a true leader, a team player, and one of the rare people that raises the bar for everyone around him.”

A full list of SEAS award descriptions and recipients can be found here.

Congratulations once again to the award winners and to all graduating students on an outstanding year of scholarship and service!

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Connecting Communities Impacted by COVID-19

Three Penn seniors combine their desire to help with their unique skill sets to create Corona Connects, an online platform that connects volunteers with organizations in need of support.

Developed by (from left) Steven Hamel from the School of Engineering and Applied Science, Megan Kyne from the Wharton School, and Hadassah Raskas from the College of Arts & Sciences, Corona Connects bridges the gap between those looking for ways to help and organizations in need of support.

by Erica K. Brockmeier

With college campuses shut due to the novel coronavirus, many students with new-found time on their hands have found themselves asking, “What can I do to help?”

To connect people with organizations that need support, three students have combined their desire to help with the skills they’ve learned both inside and outside the classroom. Developed by Penn seniors Steven Hamel from the School of Engineering and Applied Science, Megan Kyne from the Wharton School, and Hadassah Raskas from the College of Arts & Sciences, the online platform Corona Connects bridges the gap between people looking for ways to help and organizations looking for support.

After returning to her hometown of Silver Spring, Maryland, Raskas was eager to find some way to help but noticed that it was difficult to find opportunities online. With friends and colleagues voicing similar struggles, Raskas reached out to University of Maryland junior Elana Sichel and started putting together a list of organizations in need of help. Then, after reaching out on the Class of 2020 Facebook page about the project, Hamel, from Philadelphia, and Kyne, from Pittsburgh, offered their support to get an online platform up and running.

The team of students quickly realized that there was both a large number of individuals who wanted to find ways to help alongside an unprecedented level of need from numerous types of organizations. “We knew there was need, and we knew there was an availability of people, but the connection was missing, so we built Corona Connects to bridge this gap,” says Raskas.

Continue reading on Penn Today.

Steven Hamel graduated with his B.S.E. in Bioengineering and a Math minor in in 2020 and is currently pursuing a Master’s in Bioengineering.

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En Garde!: The Fencers of Penn Engineering

By Patricia Hutchings

Senior Akshay Malhotra (center) pumps up Penn Fencing. He is one of several Engineering students on the team, including senior Alexandre Amice, sophomores Kristina Khaw and Jerry Wu, and freshman Enzo Bergamo. (Photos courtesy of Penn Athletics)

What were the chances? Captivated by a fencing demonstration at his elementary school in St. Louis, MO, an American-born son of French parentage went straight home and announced his desire to learn the sport. Meanwhile, an internationally recognized fencer, who had once coached the Egyptian National team, had settled in St. Louis and was busy making plans to establish a fencing club there. Two dreams collided: The Fencers Academy of St. Louis took shape and the boy learned to fence, and to fence well. Meet Alexandre Amice (BSE’20, MSE’20).

Amice’s passion for the sport remained strong throughout high school, and the year he walked on to the Penn Fencing Team as a freshman engineering student, he was voted by the captains and coaches as Most Dedicated Fencer.

Of the three types of fencing swords: the épée, the foil and the sabre, Amice’s weapon of choice is the light and flexible foil. In foil bouts, the target area for scoring touches is limited to the torso, requiring the fencers to remain closely engaged and in constant motion. Amice characterizes his fencing style as “athletic,” with his build and skillset well-matched with his weapon.

Amice cites his measured and deliberate competition strategy as useful in his intellectual life. As he concurrently works toward his undergraduate degree in electrical engineering and mathematics and a master’s in robotics, Amice clearly is not one to waste energy.

The sabre is the weapon of choice for Penn World Scholar and freshman electrical engineering major, Enzo Bergamo. At an early age, he determined the discipline of sabre fencing to be “the cool one,” with its reputation for quickness, aggression, slashing touches and split-second decision making. Compared in speed and spirit to Formula 1 racing by Olympic sabre fencer Daryl Homer, the target area for the discipline is the entire torso, the head, and the arms up to the wrist.

Andy Ma, Penn’s head fencing coach, also serves as sabre coach, and Bergamo feels fortunate to be able to work with him one-on-one in lessons once or twice a week. After twelve years of high-level fencing in Sao Paulo, Brazil, Bergamo attributes his renewed love for the sport to Ma’s influence and attentive demeanor. For Bergamo, being able to face down frustration and maintain physical and emotional balance are valuable attributes, with or without a sword in his hand.

Bergamo notes that he and his teammates are known as “student athletes,” not “athlete students,” and, with an electrical engineering concentration in data science and a minor in computer and information science, he envisions a master’s degree in his future. Bergamo’s overarching goal, he states, is “making a positive impact in my home country.”

At 5’3,” Kristina Khaw, a sophomore bioengineering major, fences with the épée, the largest and heaviest of fencing swords. Bouts in épée have been described as “aggressive defensive,” and points can be scored with touches anywhere on the body. Fencers train especially hard to perfect their skills in counter moves.

Obeying her mother’s directive to put her books aside in favor of exercise now and again, Khaw followed her sister, Kathryn (ENG’19), onto the fencing strip. She admits that, as a seventh grader, her greatest incentive to take up the sport was watching Kathryn delightedly stab their cousin with impunity in club practice.

As Khaw describes it, the muscle memory to succeed in épée came easily to her. Her stats provide proof: From the USA Fencing Nationals in the summer of her high school sophomore year, Khaw brought back to her Plainsboro, NJ, home the title of Division ll Women’s Épée Champion. Other notable wins and honors followed.

Khaw is a problem solver by nature and believes that her strategizing as a fencer creates new brain connections, enhancing her ability to think about things in new ways. Accordingly, she finds myriad applications of her athletic training to her life as a Penn Engineer.

“One touch at a time” is Khaw’s fencing mantra and, as she continues her studies on the pre-med track, her calm and logic will undoubtedly inform her journey.

Read the full story on the Penn Engineering blog.

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A Record 15 BE Students Receive 2020 NSF Graduate Research Fellowships

The Department of Bioengineering at Penn is incredibly proud of its fifteen current and future graduate student recipients of the 2020 National Science Foundation Graduate Research Fellowship Program (NSF GRFP). This total surpasses last year’s record of twelve students. In addition, one current student was selected for honorable mention and one additional incoming student has been named a Fullbright Scholar.

The prestigious NSF GRFP program recognizes and supports outstanding graduate students in NSF-supported fields. Further information about the program can be found on the NSF website. BE is thrilled to congratulate our excellent students on these well-deserved accolades! Continue reading below for a list of 2020 recipients and descriptions of their research.

Current Students:

William Benman

William Benman is a Ph.D. student in the lab of Assistant Professor of Bioengineering, Lukasz Bugaj. His work in the Bugaj lab focuses on developing novel optogenetic tools to control and study cell function.

Paul Gehret

Paul Gehret is a Ph.D. student and Ashton Fellow in the lab of Riccardo Gottardi, Assistant Professor of Pediatrics at the Perelman School of Medicine. Paul works on pediatric cartilage and airway tissue engineering for children with subglottic stenosis. He and his team apply classic tissue engineering principles to the airway.

Rebecca Haley

Rebecca Haley is a Ph.D. student in the lab of Michael J. Mitchell, Skirkanich Assistant Professor of Innovation in Bioengineering. Her current project aims to use polymer and/or lipid nanoparticles for the intracellular delivery of proteins. Successful delivery of proteins (such as antibodies) in this fashion may allow for targeting of previously undruggable intracellular targets.

Patrick John Mulcahey

Patrick John Mulcahey is a Research Assistant and Graduate Student in the Children’s Hospital of Philadelphia (CHOP) Epilepsy Research Lab of Douglas A. Coulter, Professor of Pediatrics at the Perelman School of Medicine. His work focuses on developing techniques that combine electrophysiology with two-photon excitation microscopy to study a potential biomarker of the seizure onset zone in models of drug-refractory epilepsy.

Catherine Porter

Catherine Porter is a Ph.D. student in the lab of Alex J. Hughes, Assistant Professor of Bioengineering. She is working on developing high-throughput methods to produce and characterize human-cell-derived kidney organoids for disease modeling and genetic screening. Currently, she is focused on engineering physicochemical control to improve organoid homogeneity.

Sarah Shepherd

Sarah Shepherd is a Ph.D. student who is co-advised in the Michael J. Mitchell lab and the lab of David Issadore, Associate Professor of Bioengineering and Electrical and Systems Engineering (ESE). Her research aims to combine microfabrication with biomaterial design of lipid nanoparticles to address major shortcomings in the field of nanomedicine. Currently, she is prototyping a scale-up microfluidic device to produce lipid nanoparticles for gene therapy.

Michael Tobin

Michael Tobin is a Ph.D. student in the lab of Dennis E. Discher, Robert D. Bent Professor of Chemical and Biomolecular Engineering (CBE), Bioengineering, and Mechanical Engineering and Applied Mechanics (MEAM). His current research examines phenomena leading to mechano-induced genomic variation in multiple cell subtypes. Through better understanding of characteristic pathways and subsequent cell responses, he hopes to improve treatments for malignant solid tumors.

John Viola, a Ph.D. student in the Hughes lab, was listed as an honorable mention.

Incoming Students:

Additionally, eight NSF GRFP honorees from other institutions will be joining our department in the fall of 2020. We congratulate them as well and look forward to welcoming them to Penn:

Finally, incoming Ph.D. student Dora Racca was awarded a Fullbright Scholarship. Dora will will have rotations in the BIOLines Laboratory of Dongeun (Dan) Huh, Associate Professor of Bioengineering and the McKay Orthopaedic Research Laboratory of Robert Mauck, Mary Black Ralston Professor of Orthopaedic Surgery and Professor of Bioengineering.

We would like to send congratulations once again to all our current and future graduate students on another year of outstanding research!