Study Reveals New Insights on Brain Development Sequence Through Adolescence

by Eric Horvath

3D illustration of a human brain
Image: Courtesy of Penn Medicine News

Brain development does not occur uniformly across the brain, but follows a newly identified developmental sequence, according to a new Penn Medicine study. Brain regions that support cognitive, social, and emotional functions appear to remain malleable—or capable of changing, adapting, and remodeling—longer than other brain regions, rendering youth sensitive to socioeconomic environments through adolescence. The findings are published in Nature Neuroscience.

Researchers charted how developmental processes unfold across the human brain from the ages of 8 to 23 years old through magnetic resonance imaging (MRI). The findings indicate a new approach to understanding the order in which individual brain regions show reductions in plasticity during development.

Brain plasticity refers to the capacity for neural circuits—connections and pathways in the brain for thought, emotion, and movement—to change or reorganize in response to internal biological signals or the external environment. While it is generally understood that children have higher brain plasticity than adults, this study provides new insights into where and when reductions in plasticity occur in the brain throughout childhood and adolescence.

The findings reveal that reductions in brain plasticity occur earliest in “sensory-motor” regions, such as visual and auditory regions, and occur later in “associative” regions, such as those involved in higher-order thinking (problem solving and social learning). As a result, brain regions that support executive, social, and emotional functions appear to be particularly malleable and responsive to the environment during early adolescence, as plasticity occurs later in development.

“Studying brain development in the living human brain is challenging. A lot of neuroscientists’ understanding about brain plasticity during development actually comes from studies conducted with rodents. But rodent brains do not have many of what we refer to as the association regions of the human brain, so we know less about how these important areas develop,” says corresponding author Theodore D. Satterthwaite, the McLure Associate Professor of Psychiatry in the Perelman School of Medicine, and director of the Penn Lifespan Informatics and Neuroimaging Center (PennLINC).

Read the full story in Penn Medicine News.

N.B.: Theodore Satterthwaite in a member of the Penn Bioengineering Graduate Group.

2023 Solomon R. Pollack Awards for Excellence in Graduate Bioengineering Research

The Solomon R. Pollack Award for Excellence in Graduate Bioengineering Research is given annually to the most deserving Bioengineering graduate students who have successfully completed research that is original and recognized as being at the forefront of their field. This year, the Department of Bioengineering at the University of Pennsylvania recognizes the stellar work of four graduate students in Bioengineering.

Margaret Billingsley

Dissertation: “Ionizable Lipid Nanoparticles for mRNA CAR T Cell Engineering”

Maggie Billingsley

Margaret earned a bachelor’s degree in Biomedical Engineering from the University of Delaware where she conducted research in the Day Lab on the use of antibody-coated gold nanoparticles for the detection of circulating tumor cells. She conducted doctoral research in the lab of Michael J. Mitchell, J. and Peter Skirkanich Assistant Professor in Bioengineering. After defending her thesis at Penn in 2022, Margaret began postdoctoral training at the Massachusetts Institute of Technology (MIT) in the Hammond Lab where she is investigating the design and application of polymeric nanoparticles for combination therapies in ovarian cancer. She plans to use these experiences to continue a research career focused on drug delivery systems.

“Maggie was an absolutely prolific Ph.D. student in my lab, who pioneered the development of new mRNA lipid nanoparticle technology to engineer the immune system to target and kill tumor cells,” says Mitchell. “Maggie is incredibly well deserving of this honor, and I am so excited to see what she accomplishes next as a Postdoctoral Fellow at MIT and ultimately as a professor running her own independent laboratory at a top academic institution.”

Victoria Muir

Dissertation: “Designing Hyaluronic Acid Granular Hydrogels for Biomaterials Applications”

Victoria Muir

Victoria is currently a Princeton University Presidential Postdoctoral Research Fellow in the lab of Sujit S. Datta, where she studies microbial community behavior in 3D environments. She obtained her Ph.D. in 2022 as an NSF Graduate Research Fellow at Penn Bioengineering under the advisement of Jason A. Burdick, Adjunct Professor in Bioengineering at Penn and Bowman Endowed Professor in Chemical and Biological Engineering at the University of Colorado, Boulder. She received a B.ChE. in Chemical Engineering from the University of Delaware in 2018 as a Eugene DuPont Scholar. Outside of research, Victoria is highly active in volunteer and leadership roles within the American Institute of Chemical Engineers (AIChE), currently serving as Past Chair of the Young Professionals Community and a member of the Career and Education Operating Council (CEOC). Victoria’s career aspiration is to become a professor of chemical engineering and to lead a research program at the interaction of biomaterials, soft matter, and microbiology.

“Victoria was a fantastic Ph.D. student,” says Burdick. “She worked on important projects related to granular materials from the fundamentals to applications in tissue repair. She was also a leader in outreach activities, a great mentor to numerous undergraduates, and is already interviewing towards an independent academic position.”

Sadhana Ravikumar 

Dissertation: “Characterizing Medial Temporal Lobe Neurodegeneration Due to Tau Pathology in Alzheimer’s Disease Using Postmortem Imaging”

Sadhana Ravikumar

Sadhana completed her B.S. in Electrical Engineering at the University of Cape Town, South Africa in 2014 and her M.S. in Biomedical Engineering from Carnegie Mellon University in 2017. Outside of the lab, she enjoys spending time in nature and exploring restaurants in Philadelphia with friends. She focused her doctoral work on the development of computational image analysis techniques applied to ex vivo human brain imaging data in the Penn Image Computing and Science Laboratory of Paul Yushkevich, Professor of Radiology at the Perelman School of Medicine and member of the Penn Bioengineering Graduate Group. She hopes to continue working at the intersection of machine learning and biomedical imaging to advance personalized healthcare and drug development.

“Dr. Sadhana Ravikumar’s Ph.D. work is a tour de force that combines novel methodological contributions crafted to address the challenge of anatomical variability in ultra-high resolution ex vivo human brain MRI with new clinical knowledge on the contributions of molecular pathology to neurodegeneration in Alzheimer’s disease,” says Yushkevich. “I am thrilled that this excellent contribution, as well as Sadhana’s professionalism and commitment to mentorship, have been recognized through the Sol Pollack award.”

Hannah Zlotnick

Dissertation: “Remote Force Guided Assembly of Complex Orthopaedic Tissues”

Hannah Zlotnick

Hannah was a Ph.D. candidate in the lab of Robert Mauck, Mary Black Ralston Professor in Orthopaedic Surgery and in Bioengineering. She successfully defended her thesis and graduated in August 2022. During her Ph.D., Hannah advanced the state-of-the-art in articular cartilage repair by harnessing remote fields, such as magnetism and gravity. Using these non-invasive forces, she was able to control cell positioning within engineered tissues, similar to the cell patterns within native cartilage, and enhance the integration between cartilage and bone. Her work could be used in many tissue engineering applications to recreate complex tissues and tissue interfaces. Hannah earned a B.S. in Biological Engineering from the Massachusetts Institute of Technology (MIT) in 2017 during which time she was also a member of the women’s varsity soccer team. At Penn, Hannah was also involved in the Graduate Association of Bioengineers (GABE) intramurals & leadership, and helped jumpstart the McKay DEI committee. Since completing her Ph.D., Hannah has begun her postdoctoral research as a Schmidt Science Fellow in Jason Burdick’s lab at the University of Colorado Boulder where she looks to improve in vitro disease models for osteoarthritis.

“Hannah was an outstanding graduate student, embodying all that is amazing about Penn BE – smart, driven, inventive and outstanding in every way,” says Mauck. “ I can’t wait to see where she goes and what she accomplishes!”

Congratulations to our four amazing 2023 Sol Pollack Award winners!

Celebrating the 2023 President’s Engagement and Innovation Prize Winners

by Lauren Hertzler

At a special luncheon on campus, President Liz Magill recognized this year’s eight awardees, who she said ‘exemplify imagination, creativity, grit, and leadership.’

President Liz Magill and Interim President Beth Winkelstein with the 2023 PEP and PIP awardees.

When Kenneth Pham got the call last week, he said he was “shocked.”

“It’s kind of embarrassing, the president’s call went straight to voicemail,” the fourth-year chemistry major said. “But I called her office right back.”

Pham quickly learned that he and Catherine Chang had earned one of this year’s President’s Engagement Prizes (PEP) for their project Act First, which, once established, will provide critical first-aid training to high school students in Philadelphia. Both members of Penn’s Medical Emergency Response Team since their earliest years on campus, Pham, from South Philadelphia, and Chang, from Taiwan, hope to extend the program’s lifesaving education off campus, teaching others how to reverse opioid overdoses, successfully administer CPR, and prevent life-threatening bleeding.

“We feel honored to be recognized for the work we’ve been so passionate about, and we are so glad to finally have the opportunity to work on this,” Pham said Wednesday afternoon, sitting next to Chang as well as his parents at a celebratory luncheon for this year’s PEP, as well as President’s Innovation Prize (PIP), winners.

“After all our hard work this past year, it feels great,” added Chang, who graduated with her degree in biology in December.

President Magill meets with Sonura teammate Sophie Ishiwari and her startup’s mentor Brian Halak, from Penn Engineering.

In addition to Act First, fourth-year neuroscience major Lucy Lee has been awarded a PEP for her initiative Communities for Childbirth, and fourth-year bioengineering majors Gabriella Daltoso, Sophie Ishiwari, Gabriela Cano, Caroline Amanda Magro, and Tifara Eliana Boyce have received a PIP for their startup Sonura. All three projects will be awarded $100,000 for implementation expenses, as well as a $50,000 living stipend per team member to be used in the coming year, immediately following graduation.

“This is a uniquely Penn experience,” said President Liz Magill, speaking to the awardees and their family members and mentors at the gathering. “No other university has a program quite like this, and I would like to say that’s in part because no other university has the student body we have at Penn, so focused on creating solutions to pressing societal problems. That particular characteristic is a trait that we celebrate, coming down from—yes, you guessed it—our founder Ben Franklin.”

Read the full story in Penn Today.

 

Penn Bioengineering Senior Design Expo Featured in Technical.ly Philly

Members of Team Sonura: Tifara Boyce, Gabriela Cano, Gabriella Daltoso, Sophie Ishiwari, & Caroline Magro (credit: Penn BE Labs)

Technical.ly Philly journalist Sarah Huffman recently paid another visit to Penn Bioengineering’s George H. Stephenson Foundation Educational Laboratory & Bio-MakerSpace, this time for the 2023 Senior Design Expo. Following the annual Senior Design presentations held in the Singh Center for Nanotechnology, in which graduating fourth-year undergraduates in Bioengineering presented their final capstone projects, the Expo offered an opportunity for the teams to do live demonstrations (or demos) for the department’s internal competition judges and the wider BE community.

“In the course of the day, students presented the challenge they were aiming to solve and the technical details of their solution. After, demonstrations sought to find if the devices really worked.

‘[It’s] looking at the device as a whole, because quite frankly, you can say whatever you want at a presentation, does it really work,’ said [BE Labs Director Sevile] Mannickarottu. ‘You can make it look pretty, “but does it work?” is the big question.'”

Read “At Penn’s Senior Design Expo, students aimed to solve healthcare issues with tech devices” in Technical.ly Philly.

To learn more about the 2023 Senior Design projects, including pitch videos, abstracts, full presentations and awards, visit the Penn BE Labs Website.

Read about Technical.ly’s first visit to the Penn BE Labs here.

Two Penn Bioengineering Students Win SFB STAR Awards

Congratulations to two Bioengineering graduate students who were awarded Student Travel Achievement Recognition (STAR) Awards from the Society for Biomaterials (SFB). The STAR Award recognizes research excellence and develops future leaders within SFB and comes with a certificate and a monetary award of $250. Penn Bioengineering graduate students Rebecca Haley and Alex Hamilton, both members of the lab of Michael J. Mitchell, Skirkanich Assistant Professor of Innovation in Bioengineering, received their awards and presented on their research in the SFB annual meeting in April 2023.

Rebecca Haley, Ph.D. student in Bioengineering

Rebecca Haley is a Ph.D. student in Bioengineering and a NSF Graduate Research Fellow. In the Mitchell Lab, she focuses on the use of ionizable lipid nanoparticles for the delivery of protein cargos. Supported by this STAR award, she presented her work delivering small protein RAS-inhibitors that reduce cancer cell proliferation. Rebecca is interested in expanding the applications of lipid nanoparticle technology, allowing currently limited therapeutics to achieve functional delivery and, hopefully, clinical success.

Alex Hamilton, Ph.D. student in Bioengineering

Alex Hamilton is a Ph.D. student in Bioengineering and an NSF Graduate Research Fellow. Alex’s work in the Mitchell lab focuses on non-viral nucleic acid delivery. His research interests include cancer immunotherapy, vaccines, and fetal-maternal medicine. He is currently engaged in using novel high-throughput screening techniques to accelerate the discovery process for lipid nanoparticle development for a variety of disease applications.

Two more Mitchell Lab members were likewise recognized with honorable mention inn the STAR Awards: Hannah Safford, a Ph.D. student in Bioengineering and NSF Fellow, and Rohan Palanki, a M.D.-Ph.D. student in Bioengineering and NIH Fellow

Learn more about the Mitchell Lab’s research in biomaterials science, drug delivery, and cellular and molecular bioengineering in the lab’s website.

Read more stories featuring Mitchell and his team here.

Daeyeon Lee: Evan C Thompson Lecture and American Chemical Society Award

 Daeyeon Lee, Professor and Evan C Thompson Term Chair for Excellence in Teaching in the Department of Chemical and Biomolecular Engineering and member of the Penn Bioengineering Graduate Group, is the recipient of two recent honors.

Surrounded by his supportive research team, fellow faculty, students, School of Engineering and Applied Science Dean Vijay Kumar, and Interim Provost Beth Winkelstein, Lee recently delivered the 2023 Evan C Thompson Chair Lecture about—fittingly enough—establishing a sense of community as we return from the isolating days of the pandemic.

Daeyeon Lee of the School of Engineering and Applied Science delivers the 2023 Thompson Chair Lecture on April 4, 2023. He spoke about reconnecting in the classroom and building community.

“Students who feel connected with instructors and among peers will invest more time, work harder, and retain information better, because they feel comfortable and safe being in the classroom and making space,” Lee said in his opening remarks. “So, there are clearly lots of positive benefits to having this connectedness among students in the classroom.”

Lee’s lecture, titled “(Re)connecting in the Classroom,” was inspired by the “Great Disengagement” referenced in an article published in The Chronicle of Higher Education last year. It portrayed students as more disconnected and uncertain as they re-entered the campus environment.

Read more about Lee’s “(Re)connecting in the Classroom” in Penn Today.

In addition, Lee has received the 2022 Outstanding Achievement Award in Nanoscience from the American Chemical Society (ACS).

The annual award recognizes exceptional achievements in nanoscience research and notable leadership in the area of colloidal nanoparticles and application. Lee was chosen from a large group of extraordinary nominees among the invited speakers, “for pioneering research in development of factory-on-a-chip and its application for large scale nanoparticle synthesis and functionalization.”

Read more about this award in Penn Engineering Today.

Penn Bioengineering Senior Design Team “Sonura” Wins 2023 President’s Innovation Prize

Gabriella Daltoso, Sophie Ishiwari, Gabriela Cano, Caroline Amanda Magro, and Tifara Eliana Boyce pose on College Green.
Sonura

University of Pennsylvania President Liz Magill announced on April 21, the recipients of the 2023 President’s Engagement and Innovation Prizes.

Awarded annually, the Prizes empower Penn students to design and undertake post-graduation projects that make a positive, lasting difference in the world. Each Prize-winning project will receive $100,000, as well as a $50,000 living stipend per team member. The Prizes are the largest of their kind in higher education. All Prize recipients collaborate with a Penn faculty mentor.

A team of fourth-year Bioengineering majors, Gabriella Daltoso, Sophie Ishiwari, Gabriela Cano, Caroline Amanda Magro, and Tifara Eliana Boyce, have received the President’s Innovation Prize for their project, Sonura.

“This year’s President’s Engagement and Innovation Prize recipients are fueled by a desire to make a difference—in their community, across the country, and around the world,” Magill said. “Communities for Childbirth, Act First, and Sonura embody an inspiring blend of passion and purpose. They are addressing consequential challenges with compelling solutions, and their dedication and smarts are exemplary. I congratulate them and wish them success as they launch and grow their ventures.”

The 2023 Prize recipients—selected from an applicant pool of 76—will spend the next year implementing the projects:

Gabriella Daltoso, Sophie Ishiwari, Gabriela Cano, Caroline Amanda Magro, and Tifara Eliana Boyce for Sonura: Daltoso, from Boise, Idaho; Ishiwari, from Chicago; Cano, from Lawrenceville, New Jersey; Magro, from Alexandria, Virginia; and Boyce, from Jamaica, Queens, New York, are bioengineering majors in the School of Engineering and Applied Science. Their startup, Sonura, is developing a beanie that promotes the cognitive and socioemotional development of newborns in the NICU by protecting them from the auditory hazards of their environments while fostering parental connection. The Sonura Beanie is composed of a frequency-dependent filter and a mobile application. The Sonura team is mentored by Brian Halak, a lecturer in the Engineering Entrepreneurship program. Sonura was developed in Penn’s Stephenson Foundation Bio-MakerSpace and was part of their Bioengineering Senior Design class.

To learn more about the 2023 President’s Engagement and Innovation Prizes, visit Penn Today.

2023 Undergraduate Awards for Bioengineering Students

Congratulations to the Bioengineering student recipients of undergraduate awards from the School of Engineering and Applied Science  for the 2022-2023 academic year. These  awards are given annually by the school and the department in recognition of outstanding scholarship and service. Read the full list of Bioengineering undergraduate award winners below.

The Wolf-Hallac Award: Sofia Mouchtaris. This award was established in October 2000 to recognize the graduating female senior from across Penn Engineering’s departments who is seen as a role model, has achieved a high GPA (in the top 10% of their class), and who has demonstrated a commitment to school and/or community.

The Management and Technology Scholarship Award: Savan Patel. This prize is awarded by the SEAS faculty to that member of the senior class in the Jerome Fisher Management and Technology Program who has created an innovative system and attained high scholastic achievement.

The Hugo Otto Wolf Memorial Prize: Joshua Freedman & Le He. This prize is awarded to one or more members of each department’s senior class, distinguishing students who meet with great approval of the professors at large through “thoroughness and originality” in their work.

The Herman P. Schwan Award: Laila Norford. This department award honors a graduating senior who demonstrates the “highest standards of scholarship and academic achievement.”

Exceptional Service Awards recognize students for their outstanding service to the University and their larger communities: Dylan Hurok, Julia Lottman, Caroline Magro & Grace Qian.

The Student Leadership Award: Moses Zeidan. This award is given annually to a student in Bioengineering who has demonstrated, through a combination of academic performance, service, leadership, and personal qualities, that they will be a credit to the Department, the School, and the University.

Additionally, the Bioengineering Department  also presents a single lab group with the Albert Giandomenico Award which reflects their “teamwork, leadership, creativity, and knowledge applied to discovery-based learning in the laboratory.” This year’s group consists of Ella Atsavapranee, Jake Becker, Ruoming Fan & Savan Patel, aka Team StablEyes.

The awardees above were recognized at the annual Penn Engineering Awards Ceremony held Wednesday, March 29, 2023 in the Harrison Auditorium, Penn Museum.

Three Bioengineering Senior Design teams were chosen for recognition in the Bioengineering Senior Design Competition:

Team BAMBI: Ria Dawar, Pallavi Jonnalagadda, Jessica Ling, & Grace Qian. BAMBI (Biointelligent Apnea Monitor for Bradycardia-Prone Infants) is a tripartite system that leverages machine learning and automated mechanical stimulation to detect and treat apnea of prematurity in the NICU.

Team StablEyes: Ella Atsavapranee, Jake Becker, Ruoming Fan, & Savan Patel. StablEyes consists of a stabilization mount that provides fine, motorized control of the handheld OCT to improve ease of use for physicians and machine learning-based software to aid in diagnosis from retinal images.

Team inSPIRE: Jackson Dooley, Joshua Freedman,Yi-An Hsieh, Isabella Mirro, & Parth Mody. inSPIRE is the first smart incentive spirometer, used post-operatively to improve patient outcomes and reduce costs associated with complications and readmissions.

These teams will compete in the Penn Engineering Senior Design Competition on Friday, April 28, 2023.

Research for these projects was conducted in the George H. Stephenson Foundation Education Laboratory & Bio-Maker Space. Learn about all the 2023 Senior Design projects and view their final presentations on the Stephenson Bio-MakerSpace website here.

A full list of Penn Engineering award descriptions and recipients can be found here.

Engheta, Margulies Elected to the American Academy of Arts & Sciences

Two faculty affiliated with the Department of Bioengineering at the University of Pennsylvania have been elected to the American Academy of Arts & Sciences. They join nearly 270 new members honored in 2023, recognized for their excellence, innovation, leadership, and broad array of accomplishments.

Nader Engheta
Nader Engheta, the H. Nedwill Ramsey Professor.

Nader Engheta is the H. Nedwill Ramsey Professor, with affiliations in the departments of Electrical and Systems Engineering (primary appointment), Bioengineering (secondary appointment) and Materials Science and Engineering (secondary appointment) in the School of Engineering and Applied Science; and Physics and Astronomy (secondary appointment) in the School of Arts & Sciences. His current research activities span a broad range of areas including optics, photonics, metamaterials, electrodynamics, microwaves, nano-optics, graphene photonics, imaging and sensing inspired by eyes of animal species, microwave and optical antennas, and physics and engineering of fields and waves. He has received numerous awards for his research, including the 2023 Benjamin Franklin Medal in Electrical Engineering, the 2020 Isaac Newton Medal and Prize from the Institute of Physics (U.K.), the 2020 Max Born Award from OPTICA (formerly OSA), induction to the Canadian Academy of Engineering as an International Fellow (2019), U.S. National Academy of Inventors (2015), and the Ellis Island Medal of Honor from the Ellis Island Honors Society (2019). He joins four other Penn faculty elected to the Academy this year.

Read the announcement and the full list of Penn electees in Penn Today.

Susan Margulies, Ph.D. (Photo: Jack Kearse)

Susan Margulies, Professor in the Wallace H. Coulter Department of Biomedical Engineering in the College of Engineering at Georgia Tech, was also elected. Margulies is both Professor Emeritus in Penn Bioengineering and an alumna of the program, having earned her Ph.D. with the department in 1987. Margulies is an expert in pediatric traumatic brain injury and lung injury. She previously served as Chair of Biomedical Engineering at Georgia Tech/Emory University and in 2021 became the first biomedical engineer selected to lead the National Science Foundation’s (NSF) Directorate of Engineering.

Read the announcement of Margulies’ elected to the Academy at Georgia Tech.

Senior Design Team “StablEyes” Uses 3D Printing to Simplify Retinal Imaging

A team of Penn Bioengineering Senior Design students was featured as the 3D print of the week by the Penn Biomedical Library’s Biomeditations blog.

The StablEyes team. From left to right, Jake Becker (BE ’23), Ruoming Fan (BE ’23), Ella Atsavapranee (BE ’23), and Savan Patel (M&T ’23).

Fourth-year undergraduate students Ella Atsavapranee, Jake Becker, Ruoming Fan, and Savan Patel created StablEyes, “a stabilization mount that provides fine, motorized control of the handheld OCT to improve ease of use for physicians and machine learning-based software to aid in diagnosis from retinal images.” The team made use of 3D printing services, laboratory space, and expertise across Penn’s campus to create their innovative design, including the Bollinger Digital Fabrication Lab in the Holman Biotech Commons, the Fisher Fine Arts Library, the Children’s Hospital of Philadelphia (CHOP), and the George H. Stephenson Foundation Educational Laboratory & Bio-MakerSpace (aka the Penn BE Labs).

Read “Featured 3D Print: Simplifying Retinal Imaging with StablEyes” by Lexi Voss in Biomeditations.